Navigation Links
Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
Date:3/16/2012

vated temperature or compromise of Hsp90 function, and instead we found an entirely new pathway, with components that haven't been characterized in Candida, so it was very surprising," said Prof. Cowen.

The researchers also showed that deletion of Hms1 inhibits Candida albicans infection, pointing toward a possible clinical therapy. "We observed those weaker disease phenotypes in an insect model system, but the results suggest it may also work in more complicated systems," said Prof. Cowen.

The source of pesky vaginal and gut infections, Candida albicans is a burgeoning problem on implanted medical devicesit's fatal in roughly one-third of device-associated infectionsand is the fourth-leading cause of hospital-acquired infection. The number of acquired fungal bloodstream infections has increased by more than 200% over the last twenty years, owing in part to growing numbers of AIDS and cancer survivors whose treatments have compromised their immune function.

On finding that the Hms1 pathway affects the growth and development of Candida albicans, and knowing of other key regulators through which Hsp90 operates and suspecting many more exist, Prof. Cowen and her lab examined other pathways and proteins that interact with Hsp90 in another study.

In collaboration with Professor Gary Bader at U of T's Donnelly Centre for Cellular and Biomolecular Research, Prof. Cowen's group mapped a much larger portion of the chaperone network with which Hsp90 interacts through a "chemical genomics" approach that had never been applied to Candida albicans. "If we want to have a more global understanding of what Hsp90 is doing during the transition of this fungus between distinct morphological states with different disease causing properties, we need to take global approaches to determine what its interacting with," said Prof. Cowen.

Their results, published online today in the journal PLoS Genetics, showed 226 gene
'/>"/>

Contact: Jim Oldfield
jim.oldfield@utoronto.ca
416-946-8423
University of Toronto
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
2. UNH researchers find African farmers need better climate change data to improve farming practices
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
5. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
6. University of Tennessee researchers invent device to rapidly detect infectious disease
7. Researchers find safer way to use common but potentially dangerous medication
8. SFU researchers help discover new HIV vaccine-related tool
9. Notre Dame researchers are providing insights into elephant behavior and conservation issues
10. Researchers develop worlds first biodegradable joint implant
11. Researchers identify novel pathway responsible for infection of a common STD pathogen
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ... "iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & ... http://photos.prnewswire.com/prnh/20130307/600769 ... introduced the fingerprint reading feature with the iPhone 5S. ...
(Date:12/19/2014)... , Dec. 18, 2014  23andMe, Inc., the leading personal ... pinpoints fine-scale differences in genetic ancestry of individuals from across ... immigrants first arrived more than four hundred years ago, ... meeting place for peoples from different continents. This study illuminates ...
(Date:12/17/2014)... DUBLIN , Dec. 15, 2014 Research and Markets ... of the "Samsung Galaxy S5 - Home Button ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... the iPhone 5S, Samsung introduces for the first time ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2
... copper industry is working together to answer one very ... bronze) help curb the spread of bacteria that cause ... indicate that they can. Scientists from around the world ... and Public Health, on copper,s role in fighting the ...
... 2009 Responding to the growing popularity of a ... it is developing a new standard to be included ... food and beverage manufacturers assure the product,s quality for ... beverage industry as well as all other interested parties ...
... filament lamin A/C (LMNA) gene are associated with Emery-Dreifuss muscular ... al. show that one mechanism involves the disruption of neuromuscular ... January 5, 2009 ( www.jcb.org ) and in the January ... Biology . Muscle fiber cells contain hundreds of ...
Cached Biology News:International copper industry defines role in the fight against hospital infections 2New standard for popular stevia-based sweetener to assure product's quality 2
(Date:1/23/2015)... Biofertilizers stimulate microbial activities in soil. These microorganisms generate ... activities in the soil or in the rhizosphere. The ... on reducing environmental pollution and on reducing the usage ... the bio fertilizers market with analysis and forecasting of ...
(Date:1/22/2015)... BOSTON , Jan. 22, 2015  Transwestern | RBJ today ... feet of office space for Shire a leading biopharmaceutical company, ... . Transwestern | RBJ,s Robert Richards , president, and ... the lease for the entire five-floor building at 95 Hayden ...
(Date:1/22/2015)... January 22, 2015 Protocol Networks brings ... growing team of brand-neutral, independent consultants, Protocol Networks has ... explained that over the years, his company has attracted ... Town of Plainfield, as well as others. With the ...
(Date:1/22/2015)... 22, 2015 Controlled Substance Compliance Services ... helps companies check the legal requirements around using controlled ... China. , As their international operations expand and ... software solutions built as a result of the first ...
Breaking Biology Technology:Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 2Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 3Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 4Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Global Compliance Service for Controlled Substances to Expand to China 2
... 12 Epeius Biotechnologies Corporation today announced more stunning ... world,s first and, so far only, tumor-targeted genetic medicine ... therapy in late-stage cases of chemotherapy-resistant cancer, Rexin-G has ... much-touted biologics have failed to do: that is, to ...
... ImaginAb, Inc. and BZL Biologics, LLC have concluded ... field of diagnostic imaging for PET and SPECT. "ImaginAb ... BZL as we believe that huJ591 will form the ... and management of prostate cancer. BZL,s technology has extensive ...
... Raptor Pharmaceutical Corp. ("Raptor" or the "Company") (Nasdaq: ... treatment phase of its open-label Phase 2a clinical trial ... with non-alcoholic steatohepatitis ("NASH"), a progressive form of liver ... U.S. population. At the completion of the initial six-month ...
Cached Biology Technology:Clinical Remissions in Three Otherwise Intractable Cancers Signal the Progress of Targeted Genetic Medicine 2Clinical Remissions in Three Otherwise Intractable Cancers Signal the Progress of Targeted Genetic Medicine 3ImaginAb, Inc. and BZL Biologics, LLC Conclude Licensing Agreement for Imaging Rights to huJ591/Prostate-Specific Membrane Antigen (PSMA) 2Raptor Pharmaceutical Reports Positive Interim Phase 2a Clinical Data in Non-Alcoholic Steatohepatitis (NASH) 2Raptor Pharmaceutical Reports Positive Interim Phase 2a Clinical Data in Non-Alcoholic Steatohepatitis (NASH) 3Raptor Pharmaceutical Reports Positive Interim Phase 2a Clinical Data in Non-Alcoholic Steatohepatitis (NASH) 4Raptor Pharmaceutical Reports Positive Interim Phase 2a Clinical Data in Non-Alcoholic Steatohepatitis (NASH) 5Raptor Pharmaceutical Reports Positive Interim Phase 2a Clinical Data in Non-Alcoholic Steatohepatitis (NASH) 6
...
Anti-VDAC (Voltage-Dependent Anion Channel) AVOID FREEZE/THAW CYCLES. Recognizes the porin 31HL protein. Corresponds to mAb 1 in the literature....
This spacer is required to use the Miniature FRENCH Pressure Cell (FA-003) with the Laboratory Press....
... DNase I Amplification ... double-stranded DNA to oligodeoxyribonucleotides. ... >10000 units/mg. DNAse I ... purified and tested for ...
Biology Products: