Navigation Links
Researchers uncover allergy-cancer connection
Date:3/19/2014

While many are stocking up on allergy medicine in preparation for spring, a new study from researchers at Virginia Commonwealth University Massey Cancer Center has uncovered a new connection between allergy and cancer that could potentially lead to therapies involving common antihistamines.

Recently published in the Journal of Leukocyte Biology, the study was led by Daniel H. Conrad, Ph.D., member of the Cancer Cell Signaling research program at Massey and professor of microbiology and immunology at the VCU School of Medicine, with substantial contributions from Ph.D. students and co-first authors Rebecca K. Martin and Sheinei J. Saleem. The study demonstrated that histamine, a component of the immune system that responds to allergens and foreign pathogens and is also linked to inflammation, plays a role in protecting tumors from the immune system. By blocking the production of histamine in animal models, the researchers were able to interrupt a process that promotes melanoma growth.

"This research is very exciting as it draws a connection between two diseases that aren't commonly linked: allergy and cancer," says Conrad. "However, it's important to realize that this connection is very novel and further research is needed before we know if antihistamines can be used effectively in cancer therapies."

Histamine is produced by mast cells, which are especially numerous in the nose, mouth and blood vessels to help defend against pathogens and aid in wound healing. The researchers found that histamine induces the activation, survival and proliferation of myeloid derived suppressor cells (MDSCs), which help promote tumor growth by suppressing the immune system. They also discovered that MDSCs tend to migrate toward mast cells, which help traffic the MDSCs to sites of inflammation such as the liver and tumors. The cycle continues as histamine released by mast cells further promotes the survival and proliferation of MDSCs. This occurs in two subpopulations of MDSCs, but most dramatically in the monocytic subpopulation. Through their experiments, the researchers showed that monocytic MDSCs can be decreased by over-the-counter antihistamines such as cetirizine (Zyrtec) and cimetidine (Tagamet).

In addition, the researchers found that patients experiencing allergic symptoms have more MDSCs circulating in their bloodstream than non-allergic patients.

"MDSCs have generated a great deal of interest in recent years because they limit the effects of the immune response against cancer," says study collaborator Harry D. Bear, M.D., Ph.D., member of the Developmental Therapeutics research program at Massey, professor and chair of the Division of Surgical Oncology at the VCU School of Medicine and director of the Breast Health Center at VCU Health System. "Now that we have shown that antihistamines can interfere with the production of MDSCs, we are hopeful that we may be able to use them to restore the immune system's ability to fight off tumors."

Previously, the research team found that mast cells were essential for MDSC activity. Their next step is to further dissect the mechanism of the mast cell and MDSC interaction and the involvement of other mast cell mediators, like histamine, in MDSC function.


'/>"/>

Contact: Alaina Schneider
afschneider@vcu.edu
804-628-4578
Virginia Commonwealth University
Source:Eurekalert  

Related biology news :

1. Vanderbilt diabetes researchers track cells ability to regenerate
2. Researchers devise new, stretchable antenna for wearable health monitoring
3. Researchers find high acceptability of 3-colored raspberry jelly
4. Motion and muscles dont always work in lockstep, researchers find in surprising new study
5. New bilateral pilot opportunity will fund collaborations between US and UK bioscience researchers
6. Bucking conventional wisdom, researchers find black sea bass tougher than expected
7. Researchers reveal gap in carbon capture and sequestration education
8. Researchers show that bold baboons learn to solve tasks from other baboons
9. A tale of 2 data sets: New DNA analysis strategy helps researchers cut through the dirt
10. Penn researchers model a key breaking point involved in traumatic brain injury
11. Promising news for solar fuels from Berkeley Lab researchers at JCAP
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers uncover allergy-cancer connection
(Date:2/21/2017)... February 21, 2017 Der weltweite ... wachsen. Nach einem Gespräch mit mehr als 50 Vertretern aus ... zu überwinden gilt, um diese Prognose zu realisieren. ... ... Mobilisierung der finanziellen Mittel für die Biobank, die Implementierung ...
(Date:2/13/2017)... 2017 Former 9/11 Commission border counsel and ... Janice Kephart of Identity Strategy Partners, LLP, today ... "Executive Order: Protecting the Nation From Foreign Terrorist ... "As President Trump,s ,Travel Ban, Executive Order gains ... banned the travel ban, it is important that our ...
(Date:2/8/2017)... 7, 2017  Aware, Inc. (NASDAQ: AWRE ), ... financial results for its quarter and year ended December 31, ... 2016 was $3.9 million compared to $6.9 million in the ... of 2016 was $0.6 million compared to $2.6 million in ... quarter of 2016 was $0.5 million, or $0.02 per diluted ...
Breaking Biology News(10 mins):
(Date:2/28/2017)... ... February 28, 2017 , ... Surface Plasmon Resonance (SPR) is ... optical phenomenon that is sensitive to changes in the dielectric properties of the medium ... changes in refractive index occurring up to 300 nm above the metal surface (Au) ...
(Date:2/28/2017)... 2017  Phosphorus, a computational genomics and clinical ... the Phosphorus Scientific Advisory Board, an established group ... the company on the development of new products ... visit http://phosphorus.com/about-us/ to learn more about ... gathered some of the top leaders in the ...
(Date:2/28/2017)... 28, 2017  Xencor, Inc. (NASDAQ: XNCR), a clinical-stage ... treatment of autoimmune diseases, asthma and allergic diseases ... fourth quarter and full year ended December 31, ... recent business and clinical highlights. "During ... development pipeline by starting five clinical trials across ...
(Date:2/28/2017)... MA (PRWEB) , ... February 28, 2017 , ... ... clinical trials, yet requires extensive coordination and expertise. Colpitts Clinical Trial Travel ... celebrating 15 years of meeting this unique need within the biotechnology and pharmaceutical ...
Breaking Biology Technology: