Navigation Links
Researchers tune in to protein pairs
Date:1/27/2014

Rice University scientists have created a way to interpret interactions among pairs of task-oriented proteins that relay signals. The goal is to learn how the proteins avoid crosstalk and whether they can be tuned for better performance.

Each cell contains thousands of these two-component signaling proteins, which often act as sensors and trigger the cell to act.

The new research has significance for bioengineers who try to understand and modify signaling pathways to treat disease or carry out tasks. A paper on the research done at the Center for Theoretical Biological Physics (CTBP) at Rice's BioScience Research Collaborative appears online this month in the Proceedings of the National Academy of Sciences.

The research team led by Rice physicist Jos Onuchic and bioengineer Herbert Levine used the predictive power of their pioneering direct coupling analysis statistical method to compare the genomic roots of thousands of protein pairs collected from many different bacterial organisms. Their product is a new metric to judge how mutations affect the way the pairs work.

Two-component systems are usually disconnected proteins that transmit signals to trigger many types of actions within cells. In bacteria, for instance, the first component is a histidine kinase (HK) that senses conditions outside a cell and triggers the creation of a signal in a process called "autophosphorylation." The signal (that is, the phosphoryl group) generated on the kinase can then be passed to a response regulator (RR) protein, akin to a baton in a relay race. The regulator takes the baton and then generates a physiological response through the activation or repression of genes.

A central question for the researchers was how these kinases and regulators coevolve to recognize each other in a crowd, and why there's so little crosstalk leading to mismatched pairs.

"If we are going to figure out how cells are able to compute, we
'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Ottawa researchers discover new combination therapy to kill cancer
2. Cleveland Clinic researchers discover process that turns good cholesterol bad
3. Researchers discover potential drug targets for early onset glaucoma
4. Researchers identify innate channel that protects against pain
5. Combustion continues to draw researchers to space station
6. Curtin researchers to hide our splashes from sharks
7. Researchers discover how heart arrhythmia occurs
8. Researchers collaborate to reduce effects of the aging eye
9. 1 step at a time, researchers learning how humans walk
10. Researchers discover that coevolution between humans and bacteria reduces gastric cancer risk
11. Researchers identify key components linking circadian rhythms and cell division cycles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... University] After decades of decline, grasses have returned ... the eye, the marsh in those places seems healthy ... key service of the marsh coastal protection ... the ecosystem function hasn,t come back," said ecologist Mark ... of the study in the journal Biological Conservation ...
(Date:9/16/2014)... Center for Children,s Environmental Health at the Mailman School ... association between childhood asthma and prenatal exposure to two ... Results appear online in the journal Environmental Health ... during pregnancy to higher levels of the chemicals, butylbenzyl ... percent and 78 percent increase in risk of developing ...
(Date:9/16/2014)... on September 13, 2014. The fire is human-caused and ... 2,300 acres in size and is mostly being fueled ... calm Monday night due to higher humidity. Yesterday ... beginning to construct a fireline on the West and North ... on the fire: , 7 20-person Crews, 4 Hot Shot ...
Breaking Biology News(10 mins):Cape Cod saltmarsh recovery looks good, falls short 2Cape Cod saltmarsh recovery looks good, falls short 3Phthalates heighten risk for childhood asthma 2Phthalates heighten risk for childhood asthma 3
... launched a key initiative to keep Europe at the forefront ... cell therapies to restore lost, damaged, or ageing cells and ... body,s ,master cells, that have not yet been programmed to ... of stem cells, and it is becoming clear that if ...
... (TWIC) Program, Ensures No Fraudulent Duplicate Enrollments ... Fla., June 17 ID Solutions, Inc., ... trusted,credential assurance, reported that it has been ... the Transportation Security Agency,s (TSA,s),TWIC program. The ...
... its latest state of the environment report, released ... environmental issues facing the NAFTA partners. The ... biodiversity and ecosystems, and pollution. Specific topics include ... vaquita porpoiseand the quality and quantity of water ...
Cached Biology News:European Science Foundation aims to strengthen 'regenerative medicine' 2ID Solutions Awarded Full-Production Order for Fingerprint Processing Software for TWIC 2New report looks at the state of the North American environment 2
(Date:9/17/2014)... Rockville, MD (PRWEB) September 17, 2014 ... Small Business Innovation Research (SBIR) grant to support the ... award will provide ITI with approximately $255,000 over one ... a leading cause of food allergy, affect over one ... anaphylaxis behind peanut allergy. Tree nut exposure is also ...
(Date:9/17/2014)... , Sept. 17, 2014 Intarcia Therapeutics, ... data from a study of the cost and predictability ... 50 th Annual Meeting of the European Association ... session today, Christian Frois , Ph.D., of Analysis ... series of planned Intarcia-sponsored, retrospective studies to characterize the ...
(Date:9/17/2014)... LAUDERDALE, Fla. , Sept. 17, 2014 Alternative ... an agreement to form a Special Purpose Vehicle in partnership ... based Jatropha centric agro energy company. The SPV shall be ... registered entity with AFAI as majority shareholder. The SPV shall ... Africa , particularly Ethiopia . ...
(Date:9/17/2014)... FRANCISCO, Calif. , Sept. 17, 2014 ... a molecular diagnostics company pioneering the field of molecular ... to chief operating officer. Mr. Hall joined ... the company,s commercial entry into endocrinology. Since 2012, he ... as well as managed care and billing functions. As ...
Breaking Biology Technology:Immunomic Therapeutics Awarded SBIR Grant to Develop Multi-Nut Allergy Immunotherapy 2Immunomic Therapeutics Awarded SBIR Grant to Develop Multi-Nut Allergy Immunotherapy 3Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 2Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 3Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 4Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 5AFAI Signs Joint Venture Agreement With Jatro Greentech Inc. 2AFAI Signs Joint Venture Agreement With Jatro Greentech Inc. 3Veracyte, Inc. Announces Promotion of Christopher M. Hall To Chief Operating Officer 2Veracyte, Inc. Announces Promotion of Christopher M. Hall To Chief Operating Officer 3Veracyte, Inc. Announces Promotion of Christopher M. Hall To Chief Operating Officer 4
... This release is available in German . ... magic word in electronics. Dr. Willi Auwaerter and Professor Johannes ... Universitaet Muenchen (TUM), have now presented a novel molecular switch ... functionality of the switch is the position of a single ...
... Therapeutics, Inc. today announced that Ivan Bergstein, MD, the ... the Oppenheimer 22nd Annual Healthcare Conference on Wednesday, December ... Astoria Hotel in New York City. ... Inc. is a clinical stage biopharmaceutical company developing novel ...
... 2011 Syndax Pharmaceuticals, Inc. announced today ... study, demonstrated entinostat, a novel, oral small molecule inhibitor ... single agent in patients with relapsed or refractory Hodgkin,s ... 11, from 6:00 to 8:00 PM PT at the ...
Cached Biology Technology:The smallest conceivable switch 2Stemline Therapeutics, Inc. to Present at the Oppenheimer 22nd Annual Healthcare Conference 2Entinostat Demonstrates Activity in Hodgkin's Lymphoma 2Entinostat Demonstrates Activity in Hodgkin's Lymphoma 3Entinostat Demonstrates Activity in Hodgkin's Lymphoma 4Entinostat Demonstrates Activity in Hodgkin's Lymphoma 5
... precision pressure regulator and pressurized syringe holder for ... Steady flow rate Microinjecting Fine ... Can be added to any new or existing ... manufacturer, even homemade. Connect to house air or ...
Chicken polyclonal to UCK2 ( Abpromise for all tested applications). Antigen: Full length protein, corresponding to amino acids 1-261 of Human UCK2 Entrez Gene ID: 7371 Swiss Protein ID: ...
Physical Form: powder Color: white Removes FLAG peptide from N-terminal and Met-N-terminal fusion proteins. Supplied with optimized enterokinase buffer....
Features , Designed to assist users in applying domed caps to tube strips and plates , Minimises the pressure required to seal the caps effectively , Enables multiple tubes to be sealed simultaneousl...
Biology Products: