Navigation Links
Researchers trace HIV evolution in North America
Date:4/25/2014

A study tracing the evolution of HIV in North America involving researchers at Simon Fraser University has found evidence that the virus is slowly adapting over time to its human hosts. However, this change is so gradual that it is unlikely to have an impact on vaccine design.

"Much research has focused on how HIV adapts to antiviral drugswe wanted to investigate how HIV adapts to us, its human hosts, over time," says lead author Zabrina Brumme, an assistant professor in SFU's Faculty of Health Sciences.

The study, published today in PLOS Genetics, was led by Brumme's lab in collaboration with scientists at the BC Centre for Excellence in HIV/AIDS, UBC, and sites across the U.S. including Harvard University, the New York Blood Center and the San Francisco Department of Public Health.

"HIV adapts to the immune response in reproducible ways. In theory, this could be bad news for host immunityand vaccinesif such mutations were to spread in the population," says Brumme. "Just like transmitted drug resistance can compromise treatment success, transmitted immune escape mutations could erode our ability to naturally fight HIV."

Researchers characterized HIV sequences from patients dating from 1979, the beginning of the North American HIV epidemic, to the modern day.

The team reconstructed the epidemic's ancestral HIV sequence and from there, assessed the spread of immune escape mutations in the population.

"Overall, our results show that the virus is adapting very slowly in North America," says Brumme. "In parts of the world harder hit by HIV though, rates of adaptation could be higher."

The study ends with a message of hope, Brumme adds. "We already have the tools to curb HIV in the form of treatmentand we continue to advance towards a vaccine and a cure. Together, we can stop HIV/AIDS before the virus subverts host immunity through population-level adaptation."

Numerous SFU researchers contributed to the analysis, which required the careful recovery of viral RNA from historic specimens followed by laboratory culture. A trio of SFU graduate students, including health sciences student Laura Cotton, shared the lead author role.

"It was painstaking work," says Cotton, "but it was fascinating to study these isolates in the lab, knowing that they had played an important role in the history of HIV on our continent."
'/>"/>

Contact: Zabrina Brumme
zbrumme@sfu.ca
778-782-8872
Simon Fraser University
Source:Eurekalert

Related biology news :

1. UNC researchers link aging to cellular interactions that occur across generations
2. Researchers identify a mechanism linking bariatric surgery to health benefits
3. Dana-Farber researchers uncover link between Down syndrome and leukemia
4. Stanford researchers rethink natural habitat for wildlife
5. Researchers question published no-till soil organic carbon sequestration rates
6. Researchers: Obesity can amplify bone and muscle loss
7. Researchers track down cause of eye mobility disorder
8. Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface
9. New method isolates immune cells for researchers to study how they ward off oral diseases
10. Researchers describe 4 new species of killer sponges from the deep sea
11. Finding the switch: Researchers create roadmap for gene expression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2017)... NEW YORK , Feb. 8, 2017 /PRNewswire/ ... an individual,s voice to match it against a ... voice such as pitch, cadence, and tone are ... systems require minimal hardware installation, as most PCs ... remotely for different transactions. Voice recognition biometrics are ...
(Date:2/8/2017)... , Feb. 7, 2017 The ... largely by the confluence of organizations, desires to ... for knowledge-based systems (password and challenge questions), biometrics ... and government systems. The market is driven by ... demarcation between consumer and enterprise uses cases, with ...
(Date:2/7/2017)... Ind. , Feb. 7, 2017 Zimmer ... leader in musculoskeletal healthcare, will present at the LEERINK ... New York Palace Hotel on Wednesday, February 15, 2017 ... live webcast of the presentation can be accessed at ... replay following the conference via Zimmer Biomet,s Investor Relations ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... MOINES, Iowa , Feb. 22, 2017 Origin (Origin ... agricultural biotechnology trait and seed provider, and Arcadia ... -based company that develops and commercializes agricultural productivity traits and nutritional ... a key corn biotechnology product developed in China ... of global regulatory trials. ...
(Date:2/22/2017)... ... February 22, 2017 , ... NDA Partners ... MD former Acting Deputy Director in the FDA CDRH Division of Cardiovascular, Respiratory, ... joined the company as an Expert Consultant. , In Dr. Spyker’s accomplished career, ...
(Date:2/22/2017)... DIEGO , Feb. 22, 2017  Creative ... expansion of its translational research program using its ... of laboratory facilities in San Diego.  The Company ... BioLabs facility, a biotechnology incubator sponsored by the ... In November 2016, the Company obtained an ...
(Date:2/21/2017)... 21, 2017 Synthetic Biologics, Inc. (NYSE MKT: ... microbiome to protect and restore the health of patients, intends to ... 31, 2016 on Thursday, March 2, 2017, and to host a ... information for the call is as follows: U.S. (toll ... ...
Breaking Biology Technology: