Navigation Links
Researchers trace HIV evolution in North America
Date:4/25/2014

A study tracing the evolution of HIV in North America involving researchers at Simon Fraser University has found evidence that the virus is slowly adapting over time to its human hosts. However, this change is so gradual that it is unlikely to have an impact on vaccine design.

"Much research has focused on how HIV adapts to antiviral drugswe wanted to investigate how HIV adapts to us, its human hosts, over time," says lead author Zabrina Brumme, an assistant professor in SFU's Faculty of Health Sciences.

The study, published today in PLOS Genetics, was led by Brumme's lab in collaboration with scientists at the BC Centre for Excellence in HIV/AIDS, UBC, and sites across the U.S. including Harvard University, the New York Blood Center and the San Francisco Department of Public Health.

"HIV adapts to the immune response in reproducible ways. In theory, this could be bad news for host immunityand vaccinesif such mutations were to spread in the population," says Brumme. "Just like transmitted drug resistance can compromise treatment success, transmitted immune escape mutations could erode our ability to naturally fight HIV."

Researchers characterized HIV sequences from patients dating from 1979, the beginning of the North American HIV epidemic, to the modern day.

The team reconstructed the epidemic's ancestral HIV sequence and from there, assessed the spread of immune escape mutations in the population.

"Overall, our results show that the virus is adapting very slowly in North America," says Brumme. "In parts of the world harder hit by HIV though, rates of adaptation could be higher."

The study ends with a message of hope, Brumme adds. "We already have the tools to curb HIV in the form of treatmentand we continue to advance towards a vaccine and a cure. Together, we can stop HIV/AIDS before the virus subverts host immunity through population-level adaptation."

Numerous SFU researche
'/>"/>

Contact: Zabrina Brumme
zbrumme@sfu.ca
778-782-8872
Simon Fraser University
Source:Eurekalert

Page: 1 2

Related biology news :

1. UNC researchers link aging to cellular interactions that occur across generations
2. Researchers identify a mechanism linking bariatric surgery to health benefits
3. Dana-Farber researchers uncover link between Down syndrome and leukemia
4. Stanford researchers rethink natural habitat for wildlife
5. Researchers question published no-till soil organic carbon sequestration rates
6. Researchers: Obesity can amplify bone and muscle loss
7. Researchers track down cause of eye mobility disorder
8. Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface
9. New method isolates immune cells for researchers to study how they ward off oral diseases
10. Researchers describe 4 new species of killer sponges from the deep sea
11. Finding the switch: Researchers create roadmap for gene expression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... BEDFORD, Mass., Oct. 21, 2014 Aware, Inc. (NASDAQ: ... and services, today reported financial results for its third quarter ... quarter of 2014 was $6.0 million, an increase of 40% ... Operating income in the third quarter of 2014 was $4.1 ... 2013. Higher operating income in the current three month period ...
(Date:10/18/2014)... referred for evaluation of suspected genetic conditions, whole-exome ... percent, including detection of a number of rare ... according to a study appearing in JAMA ... with the American Society of Human Genetics annual ... coding regions of thousands of genes simultaneously using ...
(Date:10/17/2014)... German . ... in order to reproduce? And why are there two sexes ... latest issue of the research journal Molecular Human Reproduction ... Ramm from Bielefeld University Bielefeld has compiled this special issue ... a female to copulate with several males in quick succession ...
Breaking Biology News(10 mins):Aware, Inc. Reports Third Quarter 2014 Financial Results 2Aware, Inc. Reports Third Quarter 2014 Financial Results 3Aware, Inc. Reports Third Quarter 2014 Financial Results 4Aware, Inc. Reports Third Quarter 2014 Financial Results 5Aware, Inc. Reports Third Quarter 2014 Financial Results 6Aware, Inc. Reports Third Quarter 2014 Financial Results 7Whole-exome sequencing shows potential as diagnostic tool 2Sperm wars 2
... for spiders, it can be a matter of life or ... potentially cannibalistic females that he is a suitable mate and ... Cincinnati shows that male wolf spiders are "leaving" little to ... mate. To improve the chances of the right message ...
... A new company has been launched to commercialise ... Strathclyde in Glasgow, for tackling bacterial infection and ... Phage Limited has been established to develop products ... prevention of infection and bacterial contamination in medicine, ...
... standard intestinal examination for diagnosing and monitoring Crohn,s disease. It ... with a camera is passed into the large intestine. MRI ... the course of the disease and how it is responding ... the academic world to develop an objective, quantitative method for ...
Cached Biology News:Spiders adjust courtship signals for maximum effect 2Spiders adjust courtship signals for maximum effect 3Spin-out to apply new technology for tackling infection 2Spin-out to apply new technology for tackling infection 3EU grant for better monitoring of Crohn's disease using MRI 2EU grant for better monitoring of Crohn's disease using MRI 3
(Date:10/20/2014)... The report “Pharmacy Automation Systems ... and Labeling Systems, Table-top Counters) by End-user (Inpatient ... & Trends to 2019” analyzes and studies the ... America, Europe, Asia-Pacific, and the Rest of the ... 30 figures spread through 300 pages and in-depth ...
(Date:10/20/2014)... 20, 2014 Asterias Biotherapeutics, Inc. (NYSE ... signed a Notice of Grant Award (NGA) with ... October 1, 2014.  The NGA provides for the ... release of additional grant funds pursuant to the ... clinical development of Asterias, product, AST-OPC1. The grant ...
(Date:10/20/2014)...  GenVec, Inc. (NASDAQ: GNVC ) today announced ... its board of directors effective on October 24, 2014.   Dr. ... as its chairman from June 2006 to November 2013.  During ... Governance and Audit Committees of the board.  ... dedicated service to GenVec, and its stockholders," said Wayne ...
(Date:10/20/2014)... Rochelle, Virginia (PRWEB) October 20, 2014 ... of NDA Partners LLC, announced today that Ellen ... and legal support for the pharmaceutical industry, has ... and manager of its legal services practice. ... reports and expert witness and testimony, to top ...
Breaking Biology Technology:Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4Zola P. Horovitz To Retire From GenVec Board 2NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2
... , , , BETHLEHEM, Pa., ... , (Logo: http://www.newscom.com/cgi-bin/prnh/200 8 1022 / ... two Lehigh Valley healthcare leaders, Good S h epherd Rehabilitation ... nc. (B. Braun), which are combining their knowledge, expertise and innovative technology ...
... , , , TUSTIN, ... today announced that it will release its financial results for the first ... EDT and will host a conference call and webcast to discuss the ... Peregrine,s senior management will discuss financial results for the first ...
... , , SEATTLE, Aug. 27 ... Company will hold an Analyst Day on Thursday, September 24, 2009 beginning ... audio webcast of the presentation will be accessible through the Investor Relations ... to listen to the live webcast, it will be archived on the ...
Cached Biology Technology:Two Lehigh Valley Healthcare Leaders Collaborate to Deliver Safer, High-Quality Care to the Community 2Two Lehigh Valley Healthcare Leaders Collaborate to Deliver Safer, High-Quality Care to the Community 3Two Lehigh Valley Healthcare Leaders Collaborate to Deliver Safer, High-Quality Care to the Community 4Peregrine Pharmaceuticals to Report First Quarter FY 2010 Financial Results 2
... The active ingredient in Molecular Probes. ... appears to act as a free ... emission. Our original SlowFade formulation (S-2828) ... rate of fluorescein to almost zero ...
... IRsolution software provides quick and easy ... functions with Windows-based control. The software ... and FDA 21 CFR Part 11 regulations, ... of measurement. IRsolutions versatility enables use ...
b6-2A12...
... reagents for immune complex disruption (ICD) of ... using a combination of low pH and ... transferred to microplate wells which are coated ... to HIV-1 p24. The immobilized monoclonal antibody ...
Biology Products: