Navigation Links
Researchers to activate anti-cancer gene
Date:8/30/2010

Colon sloughs lining

The intestines have to work properly if we are to benefit from the food we eat. Digestive juices must be secreted, the food broken down into smaller components and then transported through the gut wall and onwards to muscles and organs. The lining of the gut is coated in epithelial cells, a specialised layer that produces mucous and hormones while keeping dangerous bacteria and toxins at bay. Close contact with pathogenic microbes and toxins means that the epithelial cells may mutate to form cancer. The small intestine therefore secretes the entire epithelial layer in the course of two to five days, while the large intestine takes three weeks to perform the same process.

Gene provides cell ID

A triggered CDX2 gene tells a cell that it is located in the epithelial tissue of the intestine and thus enables the cell to do its job correctly. Associate Professor Jesper Troelsen and colleagues from the University of Copenhagen made this discovery several years ago: CDX2 may thus be regarded as an identity gene.

Cancer cells deactivate important gene

Using advanced equipment for DNA sequestration at the Department of Cellular and Molecular Medicine the research group has now revealed that CDX2 controls more than 600 other genes governing the way the cells of the intestinal epithelial tissue work, ensuring that the intestine functions properly. The discovery has now been published in the Journal of Biological Chemistry.

"Among the 600 genes we have found five that you can call anti-cancer genes", Associate Professor Troelsen says. "We have also studied early stages of colon cancer. We observed that before the colonic cancer cells began to invade the tissue outside the colon, they deactivated the CDX2 gene, removing their "ID".

"We are now applying for funds to study the properties of CDX2 that enable it to suppress colon cancer and to find a way of reactivating the CDX2
'/>"/>

Contact: DMSc Jesper Troelsen
troelsen@sund.ku.dk
452-214-2152
University of Copenhagen
Source:Eurekalert

Page: 1 2

Related biology news :

1. ISU researchers develop hybrid protein tools for gene cutting and editing
2. Researchers discover novel mechanism protecting plants against freezing
3. UK researchers release draft sequence coverage of wheat genome
4. 2 Hispanic researchers from Argonne receive national acclaim
5. Researchers find gene responsible for neurodegenerative disease in dogs, possibly in humans
6. Researchers study cinnamon extracts
7. K-state researchers explore physiological effects of space travel with NASA grant
8. Researchers connect APC protein to autism and mental retardation
9. MIT researchers develop a better way to grow stem cells
10. U of M researchers identify 2 FDA approved drugs that may fight HIV
11. Researchers advance understanding of enzyme that regulates DNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... to Europe based upon a proxy for impact have ... ,big data, approach to scientific research. , The researchers ... ranked the top 100 pathogens affecting humans and the ... they believe, will help governments across the continent plan ... including as a result of climate change, and for ...
(Date:8/27/2014)... . , Charcot-Marie-Tooth ... affecting the peripheral nervous system. Researchers from the Department ... Medicine and University Medical Centre Gttingen have discovered that ... with the disease. These cells enwrap the nerve fibres ... the rapid transfer of electrical impulses. If Schwann cells ...
(Date:8/27/2014)... York, NY (June, 2014) Outstanding basic research, ... and a dedication to patient care have earned ... Columbia University Medical Center (CUMC) and NewYork-Presbyterian Hospital ... from the National Cancer Institute (NCI). The grant ... two NCI-designated Comprehensive Cancer Centers in New York ...
Breaking Biology News(10 mins):Big data approach identifies Europe's most dangerous human and domestic animal pathogens 2Potential therapy for incurable Charcot-Marie-Tooth disease 2Herbert Irving Comprehensive Cancer Center awarded $18 million grant 2Herbert Irving Comprehensive Cancer Center awarded $18 million grant 3Herbert Irving Comprehensive Cancer Center awarded $18 million grant 4
... has named its awardee for this year,s Alan ... Brown University. Dunn,s work involves genome analyses ... He investigates the origins of biological complexity ... research holds clues about how complex multicellular organisms, ...
... This release is available in French . ... without exposing the healthy surrounding tissue to the medication,s toxic ... medical reality, thanks to the work of Professor Sylvain Martel, ... Known for being the world,s first researcher to have guided ...
... most controversial aspects in the sustainable management of golf courses. ... the practices relating to reclaimed water at one of the ... on the course receive 83% more water than they need. ... be justified from any perspective", Mara del Pino Palacios Daz, ...
Cached Biology News:Casey Dunn to receive NSF Waterman Award 2Casey Dunn to receive NSF Waterman Award 3World first -- Localized delivery of an anti-cancer drug by remote-controlled microcarriers 2Golf courses that reuse water irrigate too much 2Golf courses that reuse water irrigate too much 3
(Date:8/26/2014)... the thinnest-possible semiconductor, a new class of nanoscale ... , The University of Washington researchers have demonstrated ... be connected in an atomically seamless fashion known ... basis for next-generation flexible and transparent computing, better ... "Heterojunctions are fundamental elements of electronic and photonic ...
(Date:8/26/2014)... LONDON , Aug. 26, 2014 An ... gene structures of all Mers CoV virus ... Replikin structures back to 2012.  This conservation and sharing ... of a Synthetic Mers CoV Blocker-Vaccine™ candidate, as it did ... Shrimp vaccine, both of which have been found to ...
(Date:8/26/2014)... been added to the growing case for graphene ... big thing in the high-tech world by the ... collaboration of researchers led by a scientist with ... National Laboratory (Berkeley Lab) has reported the first ... MX2 materials. The recorded charge transfer time clocked ...
(Date:8/26/2014)...  ViveBio, LLC a leading provider of products ... announced today that it has signed a distribution ... Knoxville, Tennessee to distribute ... United States . ViveST is the first ... biological specimen transport systems.  The technology enables easy, ...
Breaking Biology Technology:Scientists craft atomically seamless, thinnest-possible semiconductor junctions 2Competition for graphene 2ViveBio and Laboratory Procurement Services Sign Agreement for Distribution of the ViveST Line of Products 2
... Distributor in Greece, to Purchase an Aggregate ... of Over $200,000 of Resurgex(R) in 2008, ... wholly owned subsidiary of Millennium,Biotechnologies Group, Inc. (OTC Bulletin Board: ... order for the international,distribution of the Resurgex(R) line in Greece. ...
... CAMBRIDGE, Mass., April 1, 2008 Abt ... Abt Bio-Pharma Solutions, Inc., a,wholly owned subsidiary of ... custom strategic, research and communication solutions for the,pharmaceutical, ... approach that blends decades of experience with wide,ranging ...
... MONTREAL, April 1 /PRNewswire-FirstCall/ - AEterna,Zentaris Inc. ... global biopharmaceutical company,focused on endocrine therapy and ... leading Canadian specialty pharmaceutical company, announced today,that, ... transactions under their,previously announced purchase and sale ...
Cached Biology Technology:Millennium Announces $200,000 Purchase Order From Greek Distributor 2Millennium Announces $200,000 Purchase Order From Greek Distributor 3Abt Associates Clinical Trials Announces Name Change to Abt Bio-Pharma Solutions, Inc. 2AEterna Zentaris and Paladin Labs Complete Sale and Purchase of Miltefosine Rights 2AEterna Zentaris and Paladin Labs Complete Sale and Purchase of Miltefosine Rights 3
Yersinia pestis...
Rabbit polyclonal to Olfactory Receptor LS189744 ( Abpromise for all tested applications)....
Recognizes the VZV nucleocapsid by indirect immunofluorescence and immunoprecipitation. Shows cross-reactivity to HSV....
Mouse monoclonal [11C9] to Zeralenone ( Abpromise for all tested applications). Antigen: Chemical / Small Molecule conjugated to BSA: Zeralenone...
Biology Products: