Navigation Links
Researchers to activate anti-cancer gene
Date:8/30/2010

Colon sloughs lining

The intestines have to work properly if we are to benefit from the food we eat. Digestive juices must be secreted, the food broken down into smaller components and then transported through the gut wall and onwards to muscles and organs. The lining of the gut is coated in epithelial cells, a specialised layer that produces mucous and hormones while keeping dangerous bacteria and toxins at bay. Close contact with pathogenic microbes and toxins means that the epithelial cells may mutate to form cancer. The small intestine therefore secretes the entire epithelial layer in the course of two to five days, while the large intestine takes three weeks to perform the same process.

Gene provides cell ID

A triggered CDX2 gene tells a cell that it is located in the epithelial tissue of the intestine and thus enables the cell to do its job correctly. Associate Professor Jesper Troelsen and colleagues from the University of Copenhagen made this discovery several years ago: CDX2 may thus be regarded as an identity gene.

Cancer cells deactivate important gene

Using advanced equipment for DNA sequestration at the Department of Cellular and Molecular Medicine the research group has now revealed that CDX2 controls more than 600 other genes governing the way the cells of the intestinal epithelial tissue work, ensuring that the intestine functions properly. The discovery has now been published in the Journal of Biological Chemistry.

"Among the 600 genes we have found five that you can call anti-cancer genes", Associate Professor Troelsen says. "We have also studied early stages of colon cancer. We observed that before the colonic cancer cells began to invade the tissue outside the colon, they deactivated the CDX2 gene, removing their "ID".

"We are now applying for funds to study the properties of CDX2 that enable it to suppress colon cancer and to find a way of reactivating the CDX2 gene to allow us to halt the progression of colon cancer".


'/>"/>

Contact: DMSc Jesper Troelsen
troelsen@sund.ku.dk
452-214-2152
University of Copenhagen
Source:Eurekalert

Related biology news :

1. ISU researchers develop hybrid protein tools for gene cutting and editing
2. Researchers discover novel mechanism protecting plants against freezing
3. UK researchers release draft sequence coverage of wheat genome
4. 2 Hispanic researchers from Argonne receive national acclaim
5. Researchers find gene responsible for neurodegenerative disease in dogs, possibly in humans
6. Researchers study cinnamon extracts
7. K-state researchers explore physiological effects of space travel with NASA grant
8. Researchers connect APC protein to autism and mental retardation
9. MIT researchers develop a better way to grow stem cells
10. U of M researchers identify 2 FDA approved drugs that may fight HIV
11. Researchers advance understanding of enzyme that regulates DNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/14/2017)... -- Wake Forest Baptist Medical Center today announced Julie Ann Freischlag, ... (CEO). Freischlag joins the medical center on May 1 ... who last year announced that he would transition to ... it since 2008.   As CEO, Freischlag ... academic health system, which includes Wake Forest School of ...
(Date:2/13/2017)... , Feb. 13, 2017 Former 9/11 ... Senate Judiciary Committee, Janice Kephart of Identity ... President Donald Trump,s "Executive Order: Protecting the ... (Jan. 27, 2017):  "As President Trump,s ,Travel ... Circuit has now essentially banned the travel ban, it ...
(Date:2/9/2017)... Feb. 9, 2017 The biomass boiler market ... the biomass boiler market globally in terms of revenue ... boilers. The market for biomass boilers has been segmented ... application, and country/region. The market based on feedstock type, ... residues, biogas & energy crops, urban residues, and others. ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... and WASHINGTON , March 28, ... provider, GENEWIZ, will launch single-cell sequencing during the American Association ... E. Washington Convention Center in Washington, D.C. ... to perform differential gene expression of thousands of cells ... Experts on-hand at AACR ...
(Date:3/28/2017)... March 28, 2017 Dr. Chris ... sciences corporation Anpac Bio-Medical Science Company , ... international record, processing and reporting over 40,000 cases ... Analysis" (CDA) liquid biopsy tests. ... Laureate Summit publications, Anpac Bio,s CDA medical devices ...
(Date:3/28/2017)... March 28, 2017 Focus ... unpredictable sector due to the scientifically intensive operations ... medical, agricultural, environmental, and industrial. In today,s pre-market research, ... Pharmaceuticals Inc. (NASDAQ: PTLA), OvaScience Inc. (NASDAQ: OVAS), ... Inc. (NASDAQ: OCUL ). Learn more ...
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... ... Harvill as Chief Executive Officer with Avomeen Analytical Services. Harvill is a distinguished ... and operations. , Avomeen is a leader in a wide range of ...
Breaking Biology Technology: