Navigation Links
Researchers tap into a new and potentially better source of platelets for transfusion
Date:7/28/2008

Clot-forming blood cells, or platelets, can drop to dangerously low levels in diseases such as anemia and in patients undergoing chemotherapy. To replace these critical cells, doctors filter platelets from donated blood, but this approach can increase the risk of transmitting blood infections and cause other side effects in patients who need frequent transfusions.

To get around these problems, scientists have been trying to generate platelets from embryonic stem cell lines. But stem cells also give rise to other types of cells, which tend to quickly outnumber the platelets. The Japanese group solved this problem with a simple refinementthey started with a stem cell population that was already committed to becoming platelets.

Another problem with making platelets from stem cells is that the resulting platelets often fail to form clots properly. This defect can be caused by the presence of enzymes that shear adhesive proteins from the cells' surface, preventing them from sticking to one another or to blood vessel walls. The researchers found these enzymes in their laboratory cultures and showed that blocking them restored platelet function when the cells were infused into injured mice. The scientists now plan to test whether the same approach will work in humans.


'/>"/>

Contact: Hema Bashyam
hbashyam@rockefeller.edu
212-327-7053
Journal of Experimental Medicine
Source:Eurekalert

Page: 1

Related biology news :

1. CMV infections affect more than just patients with compromised immune systems, researchers find
2. A new cellular pathway linked to cancer is identified by NYU researchers
3. Researchers find key to saving the worlds lakes
4. MIT researchers offer glimpse of rare mutant cells
5. UC San Diego researchers could help US military thwart explosive threats
6. As rates rise, researchers find better way to identify melanoma
7. Researchers discover a gene that regulates and blocks ovulation
8. Researchers discover link between organ transplantation and increased cancer risk
9. Dartmouth researchers discover gene signatures for scleroderma
10. Louisiana Tech researchers feature drug reformulation in prestigious journal
11. UCLA researchers locate and image prostate cancer as it spreads to lymph nodes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2017)... LONDON , April 6, 2017 ... Control, RFID, ANPR, Document Readers, by End-Use (Transportation & ... Energy Facility, Oil, Gas & Fossil Generation Facility, Nuclear ... Healthcare, Educational, Other) Are you looking for ... Authentication sector? ...
(Date:4/5/2017)... NEW YORK , April 5, 2017 ... security, is announcing that the server component of the ... is known for providing the end-to-end security architecture that ... customers. HYPR has already secured over 15 ... system makers including manufacturers of connected home product suites ...
(Date:4/4/2017)... 4, 2017   EyeLock LLC , a leader ... United States Patent and Trademark Office (USPTO) has issued ... linking of an iris image with a face image ... the company,s 45 th issued patent. ... timely given the multi-modal biometric capabilities that have recently ...
Breaking Biology News(10 mins):
(Date:9/19/2017)... ... September 19, 2017 , ... ... for surgical applications, announced today that two new patents have been allowed by ... MD, Co-Founder of Band-LOK, said, “We continue to explore additional clinically-relevant designs for ...
(Date:9/18/2017)... ... September 18, 2017 , ... USDM Life Sciences ... the life sciences and healthcare industries, announces Bryan Coddington and ... Transformation in Medical Device – The Journey to FDA Compliant Field Service and ...
(Date:9/14/2017)... Philadelphia PA and London UK (PRWEB) , ... ... ... company, will gather the most innovative minds in pharma and biotech at the ... is a two-day collaborative conference that brings together the world’s most progressive clinical ...
(Date:9/14/2017)... Antonio, Texas (PRWEB) , ... September 14, 2017 , ... ... San Antonio on Saturday, Sept. 16. , For six hours that day, the GenCure ... Match registry at more than 30 H-E-B grocery stores in San Antonio. , The ...
Breaking Biology Technology: