Navigation Links
Researchers tap into a new and potentially better source of platelets for transfusion
Date:7/28/2008

Clot-forming blood cells, or platelets, can drop to dangerously low levels in diseases such as anemia and in patients undergoing chemotherapy. To replace these critical cells, doctors filter platelets from donated blood, but this approach can increase the risk of transmitting blood infections and cause other side effects in patients who need frequent transfusions.

To get around these problems, scientists have been trying to generate platelets from embryonic stem cell lines. But stem cells also give rise to other types of cells, which tend to quickly outnumber the platelets. The Japanese group solved this problem with a simple refinementthey started with a stem cell population that was already committed to becoming platelets.

Another problem with making platelets from stem cells is that the resulting platelets often fail to form clots properly. This defect can be caused by the presence of enzymes that shear adhesive proteins from the cells' surface, preventing them from sticking to one another or to blood vessel walls. The researchers found these enzymes in their laboratory cultures and showed that blocking them restored platelet function when the cells were infused into injured mice. The scientists now plan to test whether the same approach will work in humans.


'/>"/>

Contact: Hema Bashyam
hbashyam@rockefeller.edu
212-327-7053
Journal of Experimental Medicine
Source:Eurekalert

Page: 1

Related biology news :

1. CMV infections affect more than just patients with compromised immune systems, researchers find
2. A new cellular pathway linked to cancer is identified by NYU researchers
3. Researchers find key to saving the worlds lakes
4. MIT researchers offer glimpse of rare mutant cells
5. UC San Diego researchers could help US military thwart explosive threats
6. As rates rise, researchers find better way to identify melanoma
7. Researchers discover a gene that regulates and blocks ovulation
8. Researchers discover link between organ transplantation and increased cancer risk
9. Dartmouth researchers discover gene signatures for scleroderma
10. Louisiana Tech researchers feature drug reformulation in prestigious journal
11. UCLA researchers locate and image prostate cancer as it spreads to lymph nodes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... Czech Republic , February 8, 2016 /PRNewswire/ ... EU-regulated global payment platform which presents innovation for ... Biometrics Authentication feature called VoiceKey. --> ... platform which presents innovation for clients, comfort and ... called VoiceKey. --> Worldcore ...
(Date:2/3/2016)... Sweden , February 4, 2016 --> ... amounted to SEK 1,351.5 M (105.0), up 1,187% compared with fourth quarter ... profit amounted to SEK 517.6 M (loss: 30.0). Earnings per ... operating activities was SEK 537.4 M (neg: 74.7). , ... , Revenues amounted to SEK 2,900.5 M (233.6), up 1,142% compared ...
(Date:2/3/2016)... 3, 2016 ... the "Emotion Detection and Recognition Market ... Others), Software Tools (Facial Expression, Voice Recognition ... Regions - Global forecast to 2020" ... http://www.researchandmarkets.com/research/d8zjcd/emotion_detection ) has announced the addition ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... ... February 10, 2016 , ... SonaCare Medical, LLC ... support program, Sonalinkā„¢ remote monitoring. The inaugural launch of this new technology occurred ... connecting Dr. Samuel Peretsman to a HIFU technical expert at SonaCare Medical headquarters. ...
(Date:2/10/2016)... ... February 09, 2016 , ... ... current winner of the Highest Overall Customer Rating Award from Circuits Assembly , ... business units across the USA, Canada, Mexico and China. , The EMS provider, ...
(Date:2/9/2016)... ... 2016 , ... Clinovo , the cloud-based eClinical software ... Capture (EDC) system ClinCaptureand its new Contract Research Organization (CRO) Partner Program ... San Mateo, California on February 10th and 11th. Watch 2-min video . ...
(Date:2/9/2016)... , Feb. 9, 2016  DNAtrix, a ... for cancer, announced that its lead product, ... Commission as an orphan medicinal product for ... form of glioma, strikes approximately 25,000 people ... http://photos.prnewswire.com/prnh/20160208/330986LOGO --> ...
Breaking Biology Technology: