Navigation Links
Researchers take first steps towards spinal cord reconstruction following injury
Date:11/12/2007

This release is also available in French.

Montreal, November 12, 2007 - A new study has identified what may be a pivotal first step towards the regeneration of nerve cells following spinal cord injury, using the bodys own stem cells.

This seminal study, published in this weeks Proceedings of the National Academy of Science, identifies key elements in the bodys reaction to spinal injury, critical information that could lead to novel therapies for repairing previously irreversible nerve damage in the injured spinal cord.

Very little is known about why, unlike a wound to the skin for example, the adult nervous system is unable to repair itself following spinal injury. This is in contrast to the developing brain and non-mammals which can repair and regenerate after severe injuries. One clue from these systems has been the role of stem cells and their potential to develop into different cell types.

Because of their regenerative role, it is crucial to understand the movements of stem cells following brain or spinal cord injury, says Dr. Philip Horner, co-lead investigator and neuroscientist at the University of Washington. We know that stem cells are present within the spinal cord, but it was not known why they could not function to repair the damage. Surprisingly, we discovered that they actually migrate away from the lesion and the question became why what signal is telling the stem cells to move.

The researchers then tested numerous proteins and identified netrin-1 as the key molecule responsible for this migratory pattern of stem cells following injury. In the developing nervous system, netrin-1 acts as a repulsive or attractive signal, guiding nerve cells to their proper targets. In the adult spinal cord, the researchers found that netrin-1 specifically repels stem cells away from the injury site, thereby preventing stem cel
'/>"/>

Contact: Anita Kar
anita.kar@mcgill.ca
514-398-3376
Montreal Neurological Institute and Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... Biomedical Informatics at IMIM (Hospital del Mar Medical Research ... have recently published a study in eLife ... role in the evolution of new proteins, some of ... discovered., Ribosomes produce proteins from the instructions found in ... genome is RNA containing information for the synthesis of ...
(Date:9/17/2014)... Mutations in the human retinoblastoma protein gene are ... University scientists have turned to fruit fly eyes to ... , In a paper featured on the cover of ... Chemistry , Michigan State University researchers provide the first ... those present in the human cancer gene, said Irina ...
(Date:9/17/2014)... R.I. [Brown University] After decades of decline, grasses ... saltmarshes. To the eye, the marsh in those places ... that a key service of the marsh coastal ... back but the ecosystem function hasn,t come back," said ... senior author of the study in the journal ...
Breaking Biology News(10 mins):Parts of genome without a known function may play a key role in the birth of new proteins 2Abnormal properties of cancer protein revealed in fly eyes 2Cape Cod saltmarsh recovery looks good, falls short 2Cape Cod saltmarsh recovery looks good, falls short 3
... of Minnesota researchers are a key step closer to making ... funded by a $2.2 million United States Department of Energy ... in January, made the critical step by figuring out how ... the bacteria into ketones, which can be cracked to make ...
... ID An a l ... risk management, today announced the addition of three senior executives ... Steven Seoane has joined the company as vice president of ... Rando as director of analytics. Seoane, Barr and Rando bring ...
... of Wisconsin-Madison limnologist Stephen Carpenter has been awarded ... prestigious award for water-related activities, it was announced ... The award, which comes with $150,000 and a ... "whose work contributes broadly to the conservation and ...
Cached Biology News:U of M researchers close in on technology for making renewable petroleum 2ID Analytics Strengthens Management Team With Appointment of Senior Executives 2ID Analytics Strengthens Management Team With Appointment of Senior Executives 3UW-Madison lake scientist gets world's top water prize 2
(Date:9/18/2014)... 2014   Sigma-Aldrich Corporation (Nasdaq: ... into a new gene editing partnership with the ... Under the partnership, Sigma-Aldrich will provide the Vector ... and dedicated gene editing bioinformaticians. The ... at the U-M Medical School. One initiative already ...
(Date:9/18/2014)... dysplasia is a group of rare diseases that ... cartilage. Its onset hits at the fetal stage ... in the gene encoding fibroblast growth factor receptor ... of skeletal dysplasia, thanatophoric dysplasia (TD), a skeletal ... and is often lethal, and achondroplasia (ACH), which ...
(Date:9/18/2014)... new microscopy technology that allows them to view ... , Dubbed "Complementation Activated Light Microscopy" (CALM), the ... order of magnitude finer than conventional optical microscopy, ... at the nanometer scale. , In a paper ... , the researchers behind CALM used it to ...
(Date:9/18/2014)... California (PRWEB) September 18, 2014 Silicon-valley ... forces with Digitaliza TXT , the latest addition ... to its Clinical Research Organization (CRO) Program, Clinovo further ... “After three days of ClinCapture training, we are now ... TXT CEO Ana Pulido. “We can also rely on ...
Breaking Biology Technology:Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 2Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 4Researchers use iPS cells to show statin effects on diseased bone 2Researchers use iPS cells to show statin effects on diseased bone 3Scientists pioneer microscopy technique that yields fresh data on muscular dystrophy 2Digitaliza TXT Joins Clinovo’s CRO Partnership Program, Bringing Its Open Source EDC System, ClinCapture to Latin America 2Digitaliza TXT Joins Clinovo’s CRO Partnership Program, Bringing Its Open Source EDC System, ClinCapture to Latin America 3
... August 28 XTL Biopharmaceuticals,Ltd. (NASDAQ: XTLB ... in the acquisition, development and commercialization of,therapeutics for ... and hepatitis C, today announced the receipt on ... indicating that, according to the,Company,s financial statements for ...
... to the NASDAQ Capital Market, NEW YORK, ... ; LSE: XTL; TASE: XTL), a biopharmaceutical company,engaged ... the treatment of unmet medical needs, particularly,neuropathic pain ... August 23,2007, of a NASDAQ Staff Deficiency Letter ...
... CITY, Aug. 27 ARUP Laboratories, a national,clinical ... in,innovative laboratory research and development, announced today that ... Premier Purchasing,Partners, L.P., one of the nation,s largest ... The agreement extends a previous,contract between ARUP and ...
Cached Biology Technology:XTL Receives Staff Letter From NASDAQ; XTL may Transfer its ADR Listing to the NASDAQ Capital Market 2XTL Receives Staff Letter From NASDAQ; XTL may Transfer its ADR Listing to the NASDAQ Capital Market 3XTL Receives Staff Letter From NASDAQ 2XTL Receives Staff Letter From NASDAQ 3ARUP Laboratories and Premier Extend Contract for Reference Laboratory Testing Services 2
... Mouse L1210 cells were cultured in DMEM and ... In order to keep the antigens in their ... The cells are arrayed on a 12-well (5 ... specifically treated to enhance cellular attachment and to ...
... P815 cells were cultured in DMEM and harvested ... order to keep the antigens in their native ... cells are arrayed on a 12-well (5 mm) ... treated to enhance cellular attachment and to minimize ...
...
Screening assay to detect the Listeria monocytogenes in food samples by,DNA amplification and molecular hybridization on a microtiter plate....
Biology Products: