Navigation Links
Researchers take first steps towards spinal cord reconstruction following injury
Date:11/12/2007

This release is also available in French.

Montreal, November 12, 2007 - A new study has identified what may be a pivotal first step towards the regeneration of nerve cells following spinal cord injury, using the bodys own stem cells.

This seminal study, published in this weeks Proceedings of the National Academy of Science, identifies key elements in the bodys reaction to spinal injury, critical information that could lead to novel therapies for repairing previously irreversible nerve damage in the injured spinal cord.

Very little is known about why, unlike a wound to the skin for example, the adult nervous system is unable to repair itself following spinal injury. This is in contrast to the developing brain and non-mammals which can repair and regenerate after severe injuries. One clue from these systems has been the role of stem cells and their potential to develop into different cell types.

Because of their regenerative role, it is crucial to understand the movements of stem cells following brain or spinal cord injury, says Dr. Philip Horner, co-lead investigator and neuroscientist at the University of Washington. We know that stem cells are present within the spinal cord, but it was not known why they could not function to repair the damage. Surprisingly, we discovered that they actually migrate away from the lesion and the question became why what signal is telling the stem cells to move.

The researchers then tested numerous proteins and identified netrin-1 as the key molecule responsible for this migratory pattern of stem cells following injury. In the developing nervous system, netrin-1 acts as a repulsive or attractive signal, guiding nerve cells to their proper targets. In the adult spinal cord, the researchers found that netrin-1 specifically repels stem cells away from the injury site, thereby preventing stem cel
'/>"/>

Contact: Anita Kar
anita.kar@mcgill.ca
514-398-3376
Montreal Neurological Institute and Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... news release is available in German . ... helper substances, in PCFs proteins are fixated in a ... stable crystals. Next, the HZB and Fudan University researchers ... used as functional materials. Their findings are being published ... (DOI: 10.1038/ncomms5634). , Proteins are sensitive molecules. Everyone knows ...
(Date:8/22/2014)... of the birds and the bees. But that ... being fertilized. The fertilization process for flowering plants ... the male and female reproductive cells. New research ... and Munich, and including Carnegie,s Wolf Frommer, David ... chemical signaling process that guides flowering plant fertilization. ...
(Date:8/21/2014)... in near darkness use a previously unknown process for ... team led by a Penn State University scientist has ... aimed at improving plant growth, harvesting energy from the ... on Lake Erie and other lakes worldwide. A paper ... Science Express edition of the journal Science ...
Breaking Biology News(10 mins):Proteins: New class of materials discovered 2Calcium and reproduction go together 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 3
... chromosomes 2 and 4 has detected the largest "gene ... evidence that human chromosome 2 arose from the fusion ... National Human Genome Research Institute (NHGRI), part of the ... a study published in the April 7 issue of ...
... Affairs Greater Los Angeles Healthcare System conducted the largest ... current modern drugs for treating hepatitis B -- a ... May 17 Annals of Internal Medicine, the study may ... that a degree of uncertainly exists on how to ...
... viruses spread through the internet is helping ecologists to ... in the British Ecological Society's Journal of Applied Ecology, ... the spiny water flea - a native of Russia ... Ecologists Jim Muirhead and Professor Hugh MacIsaac of the ...
Cached Biology News:Scientists analyze chromosomes 2 and 4 2Scientists analyze chromosomes 2 and 4 3UCLA study assesses cost-effectiveness of Hepatitis B drugs 2UCLA study assesses cost-effectiveness of Hepatitis B drugs 3Internet viruses help ecologists control invasive species 2
(Date:8/22/2014)... The first direct observations of how facets form ... towards more sophisticated and effective nanocrystal design and ... describing crystal growth breaks down at the nanoscale. ... (DOE),s Lawrence Berkeley National Laboratory (Berkeley Lab) used ... high-resolution, fast-detection camera to capture the physical ...
(Date:8/22/2014)... 22, 2014 Research and Markets ... China Gel Permeation Chromatography (GPC) Industry Report 2014" ... and China Gel Permeation Chromatography (GPC) Industry Report is ... of the global gel permeation chromatography industry with a ... a basic overview of the industry including definitions, classifications, ...
(Date:8/22/2014)... August 22, 2014 The identification ... organisms can be accelerated by exome sequencing. Built ... technologies, the custom SeqCap EZ Developer system has ... Mr. Watson will additionally present how he achieved ... available human and mouse exome kits. With over ...
(Date:8/21/2014)... Institute for Molecular Medicine Finland (FIMM), University of ... novel "man and machine" decision support system for ... described in PLOS One scientific journal ... computer vision algorithms similar to those used in ... the diagnostically most relevant areas. Tablet computers can ...
Breaking Biology Technology:Shaping the future of nanocrystals 2Shaping the future of nanocrystals 3Shaping the future of nanocrystals 4Global and China Gel Permeation Chromatography (GPC) Industry Report 2014 2Efficient Identification of Protein-Coding Variants in a Model Organism Through Exome Sequencing, New Webinar Hosted by Xtalks 2A novel 'man and machine' decision support system makes malaria diagnostics more effective 2
... . - Merge Healthcare , a provider of ... designed to overcome challenges posed by the fusing of ... several product upgrades this year as it attempts to ... product accommodates standard image reading methods obtained by PET ...
... Part II of a three-part series on the information technology ... this segment will offer a look at what Wisconsin companies ... IT worker shortage. , , Milwaukee, Wis . - ... information technology positions will go unfilled this year, and then ...
... . - John Gee knows the Bay Area and Silicon ... apply its own value proposition to building a thriving technology ... has been named president and CEO of the Information ... William C. Mortimore, who has been serving in place of ...
Cached Biology Technology:IT workforce development: A little workforce planning goes a long way 2IT workforce development: A little workforce planning goes a long way 3IT workforce development: A little workforce planning goes a long way 4IT workforce development: A little workforce planning goes a long way 5Wisconsin IT association names Gee president, CEO 2
... Time-resolved microscopy is the ultimate tool ... subcellular structures. Its applications previously have been ... because microscope optics do not transmit in ... leader in fluorescence spectroscopy, introduces a filter-based ...
... using many of the automation concepts from ... requirements are similar to those for HTS: ... 24 or 48 wells with well volumes ... the number of wells has increased to ...
... Dermal Fibroblasts (Mouse/BalbC) and media. This cell ... and is guaranteed to provide an additional ... date supplied, when used with the recommended ... 18.5 ,Applications: ,Cultivation: Plate at ...
... Sphingobeads are designed for protein ... characterize sphingosine binding proteins. An ... mL of agarose beads with ... through the terminus of the ...
Biology Products: