Navigation Links
Researchers suggest new way of looking at what causes sepsis
Date:6/23/2011

TORONTO, Ont., June 22, 2011 Researchers at St. Michael's Hospital have put forward a new theory as to what causes sepsis, an often fatal condition that occurs when infection spreads throughout the body.

Leaking blood vessels may actually be a cause of sepsis, rather than a symptom as previously thought, said Dr. Warren Lee.

Dr Lee's hypothesis and a review of recent research on sepsis were published today in the journal Science Translational Medicine.

Sepsis kills about 1,400 people a day worldwide and is the second-leading cause of death in intensive care units in Canada. Despite intense research, the death rate remains high, between 30 and 50 per cent. Treatments largely consist of surgical removal or drainage of the infected site, antibiotics and supportive care.

"The lack of therapies is not for want of effort. On the basis of promising in vitro and animal studies, many drugs have entered clinical trials only to fail, resulting in the description of sepsis research as a 'graveyard' of discovery," said Dr. Lee, a critical care physician and researcher in the hospital's L Ka Shing Knowledge Institute.

"The repeated failure of clinical trials suggests that some fundamental knowledge is lacking in our current understanding of the pathogenesis of human sepsis."

Dr. Lee said one reason previous trials may have failed is that they haven't taken into account a key feature of sepsis in humans -- diffuse microvascular leakage (widespread leakage from small blood vessels) leading to swelling in tissues and organs (edema). This causes organs throughout the body to malfunction. There have been no clinical trials of drugs designed to prevent or treat leaky blood vessels.

"This is a major change in our thinking about sepsis that could lead to novel treatments to save lives," Dr. Lee said. "Sepsis is a devastating illness. If we could develop drugs to stop blood vessels from leaking, we could save lives."


'/>"/>

Contact: Leslie Shepherd
shepherdl@smh.ca
416-864-6094
St. Michael's Hospital
Source:Eurekalert

Related biology news :

1. ORNL researchers win 7 R&D 100 awards
2. Yale researchers pinpoint reasons for dramatic rise in cesarean births
3. U of M researchers find smart decisions for changing environmental times
4. Researchers find process of cervical ripening differs between term and preterm birth
5. Rensselaer researchers secure $2.7 million NIH grant to advance scarless surgery
6. USC researchers find new clues about protein linked to Parkinsons disease
7. GW researchers receive award from NCI to study cancer from a neglected tropical disease
8. MSU plant scientist named one of the nations most innovative researchers
9. Leaky genes put evolution on the fast track, Pitt and UW-Madison researchers find
10. Researchers predict record Gulf of Mexico dead zone due to Mississippi River flooding
11. Researchers identify why dopamine replacement therapy has a paradoxical effect on cognition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2016)... http://www.researchandmarkets.com/research/p74whf/global_biometrics ) ... "Global Biometrics Market in Retail Sector 2016-2020" ... --> http://www.researchandmarkets.com/research/p74whf/global_biometrics ) has announced the ... in Retail Sector 2016-2020" report to ... and Markets ( http://www.researchandmarkets.com/research/p74whf/global_biometrics ) has announced ...
(Date:1/18/2016)... , Jan. 18, 2016  Extenua Inc., ... that simplifies the use and access of ubiquitous ... go-to-market partnership with American Cyber.  ... extensive experience leading transformational C4ISR and Cyber initiatives ... integrating the latest proven technology solutions," said ...
(Date:1/11/2016)... Jan. 11, 2016  higi, the leading retail ... retail locations, web and mobile, today announced it ... from existing investors. --> ... to further innovate higi,s health platform – its ... portal – including expanding services and programs to ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... MENLO PARK, Calif. , Feb. 4, 2016 /PRNewswire/ ... "Company"), a biopharmaceutical company focused on the development and commercialization ... at the 18 th Annual BIO CEO & ... a.m. EST in New York, NY . ... will provide an update on the ongoing clinical trial of ...
(Date:2/4/2016)... Feb. 4, 2016 Sinovac Biotech Ltd. ("Sinovac" ... provider of biopharmaceutical products in China ... board of directors received on February 4, 2016 a ... a consortium comprised of PKU V-Ming ( Shanghai ... Ltd., CICC Qianhai Development ( Shenzhen ) ...
(Date:2/3/2016)... , Feb. 3, 2016   ViaCyte, ... with the first pluripotent stem cell-derived islet replacement ... in clinical-stage development, today announced that ViaCyte and ... Companies of Johnson & Johnson, have agreed to ... into ViaCyte.  The agreement provides ViaCyte with an ...
(Date:2/3/2016)... and HOLLISTON, Mass., Feb. 3, 2016 Harvard ... a biotechnology company developing bioengineered organ implants for ... today announced that CEO Jim McGorry , ... Investor Conference on Tuesday, February 9, 2016 ... York City . HART,s presentation will be ...
Breaking Biology Technology: