Navigation Links
Researchers suggest new way of looking at what causes sepsis

TORONTO, Ont., June 22, 2011 Researchers at St. Michael's Hospital have put forward a new theory as to what causes sepsis, an often fatal condition that occurs when infection spreads throughout the body.

Leaking blood vessels may actually be a cause of sepsis, rather than a symptom as previously thought, said Dr. Warren Lee.

Dr Lee's hypothesis and a review of recent research on sepsis were published today in the journal Science Translational Medicine.

Sepsis kills about 1,400 people a day worldwide and is the second-leading cause of death in intensive care units in Canada. Despite intense research, the death rate remains high, between 30 and 50 per cent. Treatments largely consist of surgical removal or drainage of the infected site, antibiotics and supportive care.

"The lack of therapies is not for want of effort. On the basis of promising in vitro and animal studies, many drugs have entered clinical trials only to fail, resulting in the description of sepsis research as a 'graveyard' of discovery," said Dr. Lee, a critical care physician and researcher in the hospital's L Ka Shing Knowledge Institute.

"The repeated failure of clinical trials suggests that some fundamental knowledge is lacking in our current understanding of the pathogenesis of human sepsis."

Dr. Lee said one reason previous trials may have failed is that they haven't taken into account a key feature of sepsis in humans -- diffuse microvascular leakage (widespread leakage from small blood vessels) leading to swelling in tissues and organs (edema). This causes organs throughout the body to malfunction. There have been no clinical trials of drugs designed to prevent or treat leaky blood vessels.

"This is a major change in our thinking about sepsis that could lead to novel treatments to save lives," Dr. Lee said. "Sepsis is a devastating illness. If we could develop drugs to stop blood vessels from leaking, we could save lives."


Contact: Leslie Shepherd
St. Michael's Hospital

Related biology news :

1. ORNL researchers win 7 R&D 100 awards
2. Yale researchers pinpoint reasons for dramatic rise in cesarean births
3. U of M researchers find smart decisions for changing environmental times
4. Researchers find process of cervical ripening differs between term and preterm birth
5. Rensselaer researchers secure $2.7 million NIH grant to advance scarless surgery
6. USC researchers find new clues about protein linked to Parkinsons disease
7. GW researchers receive award from NCI to study cancer from a neglected tropical disease
8. MSU plant scientist named one of the nations most innovative researchers
9. Leaky genes put evolution on the fast track, Pitt and UW-Madison researchers find
10. Researchers predict record Gulf of Mexico dead zone due to Mississippi River flooding
11. Researchers identify why dopamine replacement therapy has a paradoxical effect on cognition
Post Your Comments:
(Date:6/22/2016)... LOS ANGELES , June 22, 2016 ... of identity management and verification solutions, has ... cutting edge software solutions for Visitor Management, ... ® provides products that add functional ... The partnership provides corporations and venues with ...
(Date:6/21/2016)... British Columbia , June 21, 2016 /PRNewswire/ ... appointed to the new role of principal product ... been named the director of customer development. Both ... NuData,s chief technical officer. The moves reflect NuData,s ... teams in response to high customer demand and ...
(Date:6/16/2016)... June 16, 2016 The ... expected to reach USD 1.83 billion by 2024, ... Research, Inc. Technological proliferation and increasing demand in ... expected to drive the market growth. ... The development of advanced multimodal techniques for ...
Breaking Biology News(10 mins):
(Date:6/27/2016)...  Liquid Biotech USA , ... Sponsored Research Agreement with The University of Pennsylvania ... cancer patients.  The funding will be used to ... clinical outcomes in cancer patients undergoing a variety ... employed to support the design of a therapeutic, ...
(Date:6/24/2016)... ... ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical journal articles ... findings are the subject of a new article on the Surviving Mesothelioma website. ... blood, lung fluid or tissue of mesothelioma patients that can help point doctors to ...
(Date:6/23/2016)... June 23, 2016 A person commits a crime, ... scene to track the criminal down. An outbreak ... and Drug Administration (FDA) uses DNA evidence to track down ... Sound far-fetched? It,s not. The FDA has increasingly used ... investigations of foodborne illnesses. Put as simply as possible, whole ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , a ... $1 million in debt financing from Silicon Valley Bank ... automation and to advance its drug development efforts, as ... facility. "SVB has been an incredible strategic ... services a traditional bank would provide," said Dr. ...
Breaking Biology Technology: