Navigation Links
Researchers study knee stress at tissue, cellular levels
Date:7/24/2012

A Cleveland Clinic research team is developing virtual models of human knee joints to better understand how tissues and their individual cells react to heavy loads virtual models that someday can be used to understand damage mechanisms caused by the aging process or by debilitating diseases, such as osteoarthritis.

Led by Ahmet Erdemir, Ph.D., the team is leveraging the powerful computing systems of the Ohio Supercomputer Center to develop state-of-the-art computational representations of the human body to understand how movement patterns and loads on the joints deform the surrounding tissues and cells. Erdemir is the director of the Computational Biomodeling Core (CoBi) and a faculty member in the Department of Biomedical Engineering at the Lerner Research Institute (LRI) in Cleveland, Ohio.

"The aging process and debilitating diseases affect many aspects of the mechanical function of the human body: from the way we move to how our muscles, joints, tissues, and cells accommodate the loading exerted on the body during daily activities," Erdemir explained. "Computational modeling techniques provide an avenue to obtain additional insights about mechanics at various spatial scales."

Many macro-scale studies have looked at how the various components of a knee joint cartilage, menisci, ligaments and bone respond to weight and other external loads. However, Erdemir and colleague Scott C. Sibole wanted to better understand how those large mechanical forces correspond to the related deformation of individual cartilage cells or chondrocytes within the knee. Previous micro-scale studies of cartilage have not commonly been based on data from body-level scales, in particular, by the musculoskeletal mechanics of the knee joint.

In addition, calculated deformations typically have been for a single cell at the center of a 100-cubic-micrometer block of simulated tissue; Erdemir used an anatomically based representation that calculated deformations for 11 cells distributed within the same volume.

"In both micro-scale approaches, the cartilage cells experienced amplified deformations compared to those at the macro-scale, predicted by simulating the compression of tissues in the knee joint under the weight of the body," Erdemir found. "In the 11-cell case, all cells experienced less deformation than the single cell case, and also exhibited a larger variance in deformation compared to other cells residing in the same block."

Erdemir's method proved to be highly scalable because of micro-scale model independence that allowed exploitation of distributed memory computing architecture. As a result, Sibole, a research engineer at LRI, was able to leverage the computational muscle of OSC's IBM 1350 Glenn Cluster. At the time, the 9,500 nodes of the Glenn Cluster provided 75 teraflops of computing power, tech-speak for 75 trillion calculations per second. Recently, the Glenn Cluster was partially decommissioned when engineers deployed the center's more powerful HP-Intel Xeon Oakley Cluster.

"Both of OSC's two most recent flagship computing systems were specifically designed to support biomedical applications, such as those employed by Dr. Erdemir and Mr. Sibole," said Ashok Krishnamurthy, OSC interim co-executive director. "Researchers working at Ohio's various respected medical centers are conducting an ever-increasing load of computational studies and analyses, and they now represent a significant share of our user community."


'/>"/>

Contact: Jamie Abel
jabel@oh-tech.org
614-292-6495
Ohio Supercomputer Center
Source:Eurekalert  

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers study knee stress at tissue, cellular levels
(Date:6/16/2016)... 2016 The global ... reach USD 1.83 billion by 2024, according to ... Technological proliferation and increasing demand in commercial buildings, ... drive the market growth.      (Logo: ... development of advanced multimodal techniques for biometric authentication ...
(Date:6/3/2016)... , June 3, 2016 ... Management) von Nepal ... und Lieferung hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, ... führend in der Produktion und Implementierung von ... der Ausschreibung im Januar teilgenommen, aber Decatur ...
(Date:5/24/2016)... Ampronix facilitates superior patient care by providing unparalleled technology to leaders of the medical ... premium product recently added to the range of products distributed by Ampronix. ... ... ... Ampronix News ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... -- Houston Methodist Willowbrook Hospital has signed a ... serve as their official health care provider. As ... provide sponsorship support, athletic training services, and most ... athletes and families. "We are excited ... to bring Houston Methodist quality services and programs ...
(Date:6/23/2016)... 23, 2016   EpiBiome , a precision microbiome ... in debt financing from Silicon Valley Bank (SVB). The ... to advance its drug development efforts, as well as ... "SVB has been an incredible strategic partner to ... traditional bank would provide," said Dr. Aeron Tynes ...
(Date:6/23/2016)... , June 23, 2016 Apellis Pharmaceuticals, ... 1 clinical trials of its complement C3 inhibitor, ... and multiple ascending dose studies designed to assess ... of subcutaneous injection in healthy adult volunteers. ... either as a single dose (ranging from 45 ...
(Date:6/23/2016)... CA (PRWEB) , ... June 23, 2016 , ... ... software, is exhibiting at the Pennsylvania Convention Center and will showcase its product’s ... conference. ClinCapture will also be presenting a scientific poster on Disrupting Clinical Trials ...
Breaking Biology Technology: