Navigation Links
Researchers study aging's effect on the brain
Date:10/10/2011

Research by biologists at the University of York and Hull York Medical School has revealed important new information about the way the brain is affected by age.

Working with scientists at the Peninsula College of Medicine and Dentistry in Plymouth, they have studied responses to stress in synapses -- neuronal connections.

The researchers discovered that under stressful conditions, such as neuro-degeneration, resulting high energy forms of damaging oxygen cause synapses to grow excessively, potentially contributing to dysfunction.

Such stresses occur during neurodegenerative disease such as Alzheimer's and Parkinson's Disease.

The research, which was funded by the Medical Research Council and the Biotechnology and Biological Sciences Research Council, is published in the latest issue of the Proceedings of the National Academy of Sciences (PNAS).

Laboratory modelling was carried out using Drosophila, but similar pathways are present in humans. The scientists studied the responses using a model of lysosomal storage disease, an inherited incurable childhood neurodegeneration where enlarged synapses have been observed, but the role that growth has in disease progression and brain function is not yet clear.

Co-author Dr Sean Sweeney, of the Department of Biology at the University of York, said: "The findings have strong implications for neuronal function as brains age, and will add significantly to our understanding of neurodegenerative disease such as Alzheimer's and Parkinson's disease."

Co-author Dr Iain Robinson, of the Peninsula College of Medicine and Dentistry, added: "Neuronal contacts in the brain are constantly changing. These changes in the brain enable us to form short term memories such as where we parked the car, or longer term memories, such as what is our pin number for the cash point machine. Our work sheds light on how our brain becomes less able to make these chan
'/>"/>

Contact: David Garner
david.garner@york.ac.uk
44-190-432-2153
University of York
Source:Eurekalert

Page: 1 2

Related biology news :

1. Notre Dame researchers report progress on compound to treat neurological diseases
2. UNH researchers: Multibeam sonar can map undersea gas seeps
3. Researchers realize high-power, narrowband terahertz source at room temperature
4. Researchers: Apply public trust doctrine to rescue wildlife from politics
5. Dead Sea researchers discover freshwater springs and numerous micro-organisms
6. Eating balanced meals, farm-fresh produce benefits families, communities, nutrition researchers say
7. LSU researchers find impact of oil spill in marsh fish species
8. MU researchers find new insight into fatal spinal disease
9. UCLA Engineering researchers help develop complete map of mouse genetic variation
10. Researchers develop optimal algorithm for determining focus error in eyes and cameras
11. Researchers at Cruces Hospital describe new syndrome of slight family intellectual disability
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... , Dec. 8, 2014 You,ve been here before: ... but can,t remember your password, site key or the answer ... your first grade teacher? Today, Hoyos ... app that will finally put an end to the ... 1U TM . 1U leverages a user,s smartphone to ...
(Date:12/10/2014)... 9, 2014 CIE San Diego has launched ... the connective tissue that enhances care coordination among social ... share client-level information; earned a second $1 million grant ... serving seniors aging in community and; will be recognized ... 11 th 4-6p. CIE San Diego ...
(Date:12/5/2014)... 4, 2014 Increased emphasis on product ... new testing and inspection technologies. The convergence of ... a range of innovative test solutions. This trend ... Y, which is generally more inclined towards communication, ... development strategies of test equipment vendors will cater ...
Breaking Biology News(10 mins):The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4
... physical world. That,s a fact cancer researchers are beginning to ... mathematics in their efforts to understand how cancer develops -- ... researchers at the University of Michigan Comprehensive Cancer Center, has ... of the top cancer research journals and a new grant ...
... once discussed only in scientific or eco-centric circles, has ... sustainability remains elusive. On Friday, scholars and legal ... address how to meet mankind,s present needs without compromising ... The Environmental & Energy Law & Policy Journal,s fifth ...
... chemicals from plant material could produce liquid fuel for just ... the infrastructure is set up in the right way, states ... Bioproducts & Biorefining . Developed by scientists at the ... as bioliq, and is able to produce a range of ...
Cached Biology News:Physics, math provide clues to unraveling cancer 2Symposium at UH will address how to put 'sustainability' into practice 2Novel technology could produce biofuel for around 0.50 a liter ($2.49 a gallon) 2
(Date:12/22/2014)... 2014   Synthetic Biologics, Inc. ... therapies for serious infections and diseases, with ... announced positive topline safety and tolerability results ... SYN-004, the Company,s investigational oral beta-lactamase enzyme ... (C. difficile) infection, antibiotic-associated diarrhea and ...
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/19/2014)... Tigard, OR and Hershey, PA (PRWEB) December 19, ... (OTC Pink: BJCT), a leading developer and manufacturer ... has entered into an agreement with Immunomic Therapeutics, ... Bioject’s Biojector®-2000 needle-free injection device with its LAMP™ ... receives an option for an exclusive Worldwide license ...
(Date:12/19/2014)... 19, 2014  Roche (SIX: RO, ROG; OTCQX: RHHBY) ... (Bina), a privately held company based in ... provides a big data platform for centralized management ... Bina,s proprietary on-market Genomic Management Solution, Bina-GMS 1 ... perform fast and scalable analyses to maximize the ...
Breaking Biology Technology:Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3
... are pushing state restrictions on human embryonic stem ... beyond President Bush's 2001 order and put Wisconsin's ... ,Rather than adding a layer of unnecessary regulation, ... -- one federal and the other international -- ...
... are many ways to assess a workplace but in my opinion, ... of workers and unleashes their talent. , ,Emotional hot buttons are ... they work for or with. They work in a job or ... deeper and more meaningful than a good salary and generous benefits. ...
... Now that pharmaceutical giant Abbott Laboratories Inc. ... Wisconsin state line for what figures to be a major ... for creating synergies with the state's existing biotech companies. , ... 15 miles north of its world headquarters in northern Illinois, ...
Cached Biology Technology:Federal and global guidelines on stem cell research offer a level playing field 2Federal and global guidelines on stem cell research offer a level playing field 3What makes a "best place to work"? 2What makes a "best place to work"? 3What makes a "best place to work"? 4What makes a "best place to work"? 5Abbott Labs campus in Kenosha could send ripples through local biotech 2Abbott Labs campus in Kenosha could send ripples through local biotech 3
Features , Designed to assist users in applying domed caps to tube strips and plates , Minimises the pressure required to seal the caps effectively , Enables multiple tubes to be sealed simultaneousl...
Lysozyme C (W-20)...
... The Jouan B4i ventilated and BR4i refrigerated ... and low speed operation at a low sound ... accessories certified for biocontainment. Their AUTO-LOCK rotor exchange ... is ready for use within seconds. ...
... is a chromogenic substrate ... plasmids. In the presence ... lac + bacterial ... recombinant colonies appear white. ...
Biology Products: