Navigation Links
Researchers step closer to treatment of virulent hospital infection
Date:3/18/2011

Clostridium difficile is a health problem that affects hundreds of thousands of patients and costs $10 billion to $20 billion every year in North America. Researchers from the University of Calgary and the National Research Council of Canada say they are gaining a deeper understanding of this disease and are closer to developing a novel treatment using antibodies from llamas.

"We have found that relatively simple antibodies can interfere with the disease-causing toxins from C. difficile," says paper co-author Dr. Kenneth Ng, an associate professor of biological sciences at the University of Calgary and principal investigator of the Alberta Ingenuity Centre for Carbohydrate Science. "This discovery moves us a step closer to understanding how to neutralize the toxins and to create novel treatments for the disease." His research is part of a paper published today in the print issue of the Journal of Biological Chemistry.

Approximately two percent of all patients admitted to hospital may be infected by C. difficile, which thrives when healthy bacteria in the gut are weakened by antibiotics, thus allowing spores from Clostridium to germinate and colonize the large intestine.

"This research is significant because C. difficile is an increasing heath care problem and many people may experience multiple infections," says Dr. Glen Armstrong, head of the Department of Microbiology, Immunology, and Infectious Diseases in the Faculty of Medicine at the University of Calgary. "The current treatments are becoming less effective and C. difficile is developing resistance to conventional antibiotics. This research promises to provide a much-needed alternate treatment option that will overcome the failings of conventional antibiotics."

C. difficile produces two toxins -- toxin A (TcdA) and toxin B (TcdB) -- which cause damage to intestinal cells by binding to carbohydrates on the cell surface
'/>"/>

Contact: Leanne Yohemas
leanne.yohemas@ucalgary.ca
403-540-6552
University of Calgary
Source:Eurekalert  

Page: 1 2

Related biology news :

1. UCLA researchers engineer E. coli to produce record-setting amounts of alternative fuel
2. Hopkins researchers use light to move molecules
3. Zoo researchers provide African sanctuaries road map
4. Brandeis researchers use lasers, custom microscope to show gene splicing process in real time
5. Synthetic biology: TUM researchers develop novel kind of fluorescent protein
6. Researchers find drug that stops progression of Parkinsons disease in mice
7. Researchers discover new wintering grounds for humpback whales using sound
8. Berkeley Lab researchers illuminate laminins role in cancer formation
9. Researchers discover new shapes of microcompartments
10. Researchers find possible new treatment strategies for pancreatic cancer
11. Scripps oceanography researchers discover arctic blooms occurring earlier
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers step closer to treatment of virulent hospital infection
(Date:8/28/2014)... German . The ... a striking pattern of blue stripes alternating with golden stripes. ... and yellow cells emerge during growth in the skin of ... to compose the characteristic colour pattern. ,While it ... to form proper stripes, the embryonic origin of the pigment ...
(Date:8/28/2014)... Access to Research Careers) Program has announced the ... America,s 27th Annual Mouse Molecular Genetics Conference from ... Grove, California. These awards are meant to ... scientists from underrepresented groups into the mainstream of ... participation of young scientists at the Genetics Society ...
(Date:8/28/2014)... MARC (Maximizing Access to Research Careers) Program has ... College of Sports Medicine,s Conference on Integrative Physiology ... Florida. These awards are meant to promote ... from underrepresented groups into the mainstream of the ... of young scientists at the American College of ...
Breaking Biology News(10 mins):How the zebrafish gets its stripes 2How the zebrafish gets its stripes 3
... This news release is available in ... a major food staple for about 400 million people in the ... banana yields worldwide are severely threatened by pests. Dirk Hlscher from ... an international team of researchers have discovered that some banana varieties ...
... Shenzhen, China - Chinese researchers from Rui-Jin Hospital, ... other institutes identified the recurrent T372R mutation in ... related with insulinoma oncogenesis, implicating a potential marker ... neuroendocrine tumors (PNETs). The latest study was published ...
... protein deacylases has received considerable attention in recent years ... metabolic regulation. In a new study published in the ... Buck Institute researchers have now identified widespread regulation of ... Using a novel quantitative proteomic method developed at ...
Cached Biology News:Toxic substances in banana plants kill root pests 2Toxic substances in banana plants kill root pests 3Scientists identified T372R mutation as potential target for diagnosis and treatment of insulinoma 2SIRT5 regulation has dramatic effect on mitochondrial metabolism 2SIRT5 regulation has dramatic effect on mitochondrial metabolism 3
(Date:8/28/2014)... Ca. (PRWEB) August 28, 2014 Best ... rating for an alcohol-based hand sanitizer, asks food processors ... by comparing the hand sanitizer they’re currently using to ... . Hand hygiene is critical to fighting cross-contamination and ... Best Sanitizers believes there are key criteria that ...
(Date:8/28/2014)... PA (PRWEB) August 28, 2014 The ... create a culture that will allow individuals to perform ... becoming increasingly important for employers looking to compete in ... industries are embracing this trend, as the sector increasingly ... of a company, which will have real results on ...
(Date:8/28/2014)... Exciting new work by a Florida State University ... that can take your temperature, emit white light, and ... the molecule looks like a butterfly. , Biwu Ma, ... Engineering in the FAMU-FSU College of Engineering, created the ... has continued to discover that his creation has many ...
(Date:8/28/2014)... Diego, CA (PRWEB) August 28, 2014 ... Pipette.com is offering a promotion for Eppendorf ... Pipette.com customers to purchase the highest quality tubes ... Tubes are ideal for customers doing chemical, medical, ... lab technicians who are not regularly able to ...
Breaking Biology Technology:Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3
... ... Area and Beyond, ATLANTA and BALTIMORE, ... Medicine is adding an Elekta,Synergy(R) S system to its Leksell Gamma ... cancer with,both intracranial and extracranial resources for whole-body cancer,treatment with the ...
... MONICA, Calif., Aug. 17 The Foundation,for Taxpayer and ... next meeting of the fledgling Interstate Alliance for Stem ... process builds,support for publicly funded science. The decision came ... a protest from FTCR. Warren Wollschlager, of the ...
... against osteoporosis-related fractures, including spine and hip, - Reclast reduced spine ... placebo in study published in New England Journal of Medicine, - Unique once-yearly ... ... - Osteoporotic fractures affect one in two women over 50(1) and are ...
Cached Biology Technology:Johns Hopkins to add Elekta Synergy S(R) to Cancer Treatment Lineup 2Johns Hopkins to add Elekta Synergy S(R) to Cancer Treatment Lineup 3Consumer Advocates Praise Interstate Stem Cell Open Meeting Decision 2Reclast(R) Receives US FDA Approval as First and Only Once-Yearly Treatment for Women With Postmenopausal Osteoporosis 2Reclast(R) Receives US FDA Approval as First and Only Once-Yearly Treatment for Women With Postmenopausal Osteoporosis 3Reclast(R) Receives US FDA Approval as First and Only Once-Yearly Treatment for Women With Postmenopausal Osteoporosis 4Reclast(R) Receives US FDA Approval as First and Only Once-Yearly Treatment for Women With Postmenopausal Osteoporosis 5Reclast(R) Receives US FDA Approval as First and Only Once-Yearly Treatment for Women With Postmenopausal Osteoporosis 6
... Storage: The kit is stable for 12 months ... contents of the kit cold. , ,Principle: ... silica-gel based membrane which selectively adsorbs up to ... specialized binding buffers. Nucleotides, oligos ( , ,Application: ...
The Econo gradient pump rack is a preassembled rack that is used to hold the components of the Econo gradient pump kits....
... Leu DAP FLISP Assay with FAM-Labeled ... nm) • Accurately measure serine protease ... permeabilization • B-Bridge's FLISP Kits utilize ... proteases (FLISPs) to measure chymotrypsin-like activity ...
... instrument is the cycler that revolutionized ... uniformity and swappable blocks ensure consistent ... This rugged machine is more than ... for new features and upgrades as ...
Biology Products: