Navigation Links
Researchers show prebiotic can reduce severity of colitis
Date:5/3/2012

EAST LANSING, Mich. Researchers at Michigan State University have shown a prebiotic may help the body's own natural killer cells fight bacterial infection and reduce inflammation, greatly decreasing the risk of colon cancer.

Prebiotics are fiber supplements that serve as food for the trillions of tiny bacteria living in the gut. When taken, they can stimulate the growth of the "good" bacteria. The evolution of prebiotic supplements (as well as probiotics, which are actual bacteria ingested into the system) provide new therapeutic targets for researchers and physicians.

In research published in the Journal of Nutrition, MSU's Jenifer Fenton reports that mice given the prebiotic galacto-oligosaccharide, or GOS, saw the severity of their colitis (one of the main forms of inflammatory bowel disease) significantly reduced.

In fact, the mice fed GOS a synthetic compound that is known to stimulate beneficial bacteria and is found in foods such as biscuits and infant formula saw a 50 percent reduction in colitis.

Research has shown certain types of foods and fibers can reduce colon cancer risk, said Fenton of the Department of Food Science and Human Nutrition.

"There is something unique about certain types of fibers, such as GOS, and how they alter cells and influence the immune system to change disease risk, either for the good or bad," she said. "Our overall goal is to identify either dietary patterns or diet components to reduce inflammation and cancer risk.

"In this case, we used prebiotics to stimulate changes in bacteria in the gut that may have a beneficial impact on the colon."

Fenton worked closely on the project with Elizabeth Gardner, also with the Department of Food Science and Human Nutrition and who previously has looked at the impact diet plays in fighting off the flu. In applying some of the lessons learned in those studies to mice with bacterially induced colitis, the researchers found mice given GOS had significantly less inflammation and fewer abnormal cells, two precursors for colon cancer.

It appeared, Fenton said, the positive results were linked to the significant enhancement of the body's own natural killer cells, found in the immune system and crucial in fighting off new infections in the body.

"Our results suggest GOS may be effective in reducing colitis severity by priming the innate immune system," she said.

The next step is to verify how that mechanism works; finding that link could help researchers apply the lessons learned to other intestinal ailments.


'/>"/>

Contact: Jason Cody
codyja@msu.edu
517-432-0924
Michigan State University
Source:Eurekalert  

Related biology news :

1. Game on! UCLA researchers use online crowd-sourcing to diagnose malaria
2. Americas clean energy policies need a reality check, say Stanford researchers
3. Researchers find potential dark side to diets high in beta-carotene
4. Researchers at Hebrew University identify genetic systems disrupted in autistic brain
5. Light weights are just as good for building muscle, getting stronger, researchers find
6. Researchers develop rapid test strips for bacterial contamination in swimming water
7. Researchers question pulling plug on pacifiers
8. UCSD researchers: Where international climate policy has failed, grassroots efforts can succeed
9. Researchers announce GenomeSpace environment to connect genomic tools
10. Evidence shows that anti-depressants likely do more harm than good, researchers find
11. Johns Hopkins researchers uncover genes at fault for cystic fibrosis-related intestinal obstruction
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers show prebiotic can reduce severity of colitis
(Date:1/11/2017)... DES MOINES, Iowa , Jan. 11, 2017 /PRNewswire/ ... another industry first with the release of its patent-pending ... to quickly and reliably perform calibrations, securely upload data ... more flexibility for the customer. "Fighting drunk ... not only for the public at large, but also ...
(Date:1/6/2017)... , Jan. 5, 2017  Delta ID Inc., a ... scanning technology for automotive at CESĀ® 2017. Delta ID ... ) to demonstrate the use of iris scanning as ... authenticate the driver in a car, and as a ... driving experience. Delta ID and Gentex will ...
(Date:12/22/2016)... Calif. , Dec. 20, 2016  As part of ... 23andMe, the leading personal genetics company, recently released its latest ... . The book focuses on the topics of inheritance ... Generation Science Standards (NGSS) taught in elementary school classrooms in ... in a series by illustrator Ariana Killoran , whose ...
Breaking Biology News(10 mins):
(Date:1/11/2017)... AURORA, Colo. (PRWEB) , ... January 11, 2017 ... ... in the journal Clinical Cancer Research show early promise of the investigational anti-cancer ... progressed despite a median 5 previous treatment regimens. Twenty-seven percent of these heavily ...
(Date:1/11/2017)... ... 11, 2017 , ... With sepsis claiming approximately 500,000 lives ... billion, healthcare systems are looking to provide better and faster care to ... are bacteria and the yeast pathogen Candida, which can lead to severe complications ...
(Date:1/11/2017)... Colorado (PRWEB) , ... January 11, 2017 , ... ... dynamic aqueous plasma technology platforms, announced today that the National Science Foundation (NSF) ... supplement for $500,000. The funds will be used to commercialize the Symbios Tubular ...
(Date:1/11/2017)... GAITHERSBURG, Md. , Jan. 11, 2017 /PRNewswire/ ... clinical-stage gene delivery company, announced today that its ... will present a talk entitled  "AdenoVerseā„¢ platform for ... during the Biotech Showcase at the upcoming Phacilitate ... Miami , Florida.  Dr. Brough,s ...
Breaking Biology Technology: