Navigation Links
Researchers show prebiotic can reduce severity of colitis

EAST LANSING, Mich. Researchers at Michigan State University have shown a prebiotic may help the body's own natural killer cells fight bacterial infection and reduce inflammation, greatly decreasing the risk of colon cancer.

Prebiotics are fiber supplements that serve as food for the trillions of tiny bacteria living in the gut. When taken, they can stimulate the growth of the "good" bacteria. The evolution of prebiotic supplements (as well as probiotics, which are actual bacteria ingested into the system) provide new therapeutic targets for researchers and physicians.

In research published in the Journal of Nutrition, MSU's Jenifer Fenton reports that mice given the prebiotic galacto-oligosaccharide, or GOS, saw the severity of their colitis (one of the main forms of inflammatory bowel disease) significantly reduced.

In fact, the mice fed GOS a synthetic compound that is known to stimulate beneficial bacteria and is found in foods such as biscuits and infant formula saw a 50 percent reduction in colitis.

Research has shown certain types of foods and fibers can reduce colon cancer risk, said Fenton of the Department of Food Science and Human Nutrition.

"There is something unique about certain types of fibers, such as GOS, and how they alter cells and influence the immune system to change disease risk, either for the good or bad," she said. "Our overall goal is to identify either dietary patterns or diet components to reduce inflammation and cancer risk.

"In this case, we used prebiotics to stimulate changes in bacteria in the gut that may have a beneficial impact on the colon."

Fenton worked closely on the project with Elizabeth Gardner, also with the Department of Food Science and Human Nutrition and who previously has looked at the impact diet plays in fighting off the flu. In applying some of the lessons learned in those studies to mice with bacterially induced colitis, the researchers found mice given GOS had significantly less inflammation and fewer abnormal cells, two precursors for colon cancer.

It appeared, Fenton said, the positive results were linked to the significant enhancement of the body's own natural killer cells, found in the immune system and crucial in fighting off new infections in the body.

"Our results suggest GOS may be effective in reducing colitis severity by priming the innate immune system," she said.

The next step is to verify how that mechanism works; finding that link could help researchers apply the lessons learned to other intestinal ailments.


Contact: Jason Cody
Michigan State University

Related biology news :

1. Game on! UCLA researchers use online crowd-sourcing to diagnose malaria
2. Americas clean energy policies need a reality check, say Stanford researchers
3. Researchers find potential dark side to diets high in beta-carotene
4. Researchers at Hebrew University identify genetic systems disrupted in autistic brain
5. Light weights are just as good for building muscle, getting stronger, researchers find
6. Researchers develop rapid test strips for bacterial contamination in swimming water
7. Researchers question pulling plug on pacifiers
8. UCSD researchers: Where international climate policy has failed, grassroots efforts can succeed
9. Researchers announce GenomeSpace environment to connect genomic tools
10. Evidence shows that anti-depressants likely do more harm than good, researchers find
11. Johns Hopkins researchers uncover genes at fault for cystic fibrosis-related intestinal obstruction
Post Your Comments:
Related Image:
Researchers show prebiotic can reduce severity of colitis
(Date:6/27/2016)... , June 27, 2016 Research and Markets ... America 2016-2020" report to their offering. ... North America to grow at a CAGR of 12.28% ... prepared based on an in-depth market analysis with inputs from industry ... over the coming years. The report also includes a discussion of ...
(Date:6/22/2016)... June 22, 2016  The American College of Medical Genetics ... Executive Magazine as one of the fastest-growing trade shows ... at the Bellagio in Las Vegas . ... percentage of growth in each of the following categories: net ... and number of attendees. The 2015 ACMG Annual Meeting was ...
(Date:6/22/2016)... LOS ANGELES , June 22, 2016 ... of identity management and verification solutions, has ... cutting edge software solutions for Visitor Management, ... ® provides products that add functional ... The partnership provides corporations and venues with ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016 Andrew ... Published recently in ... journal from touchONCOLOGY, Andrew D Zelenetz , ... cancer care is placing an increasing burden on ... biologic therapies. With the patents on many biologics ...
(Date:6/23/2016)... ... 23, 2016 , ... ClinCapture, the only free validated electronic ... showcase its product’s latest features from June 26 to June 30, 2016 for ... Disrupting Clinical Trials in The Cloud during the conference. DIA (Drug Information ...
(Date:6/23/2016)... ... 2016 , ... Velocity Products, a division of Morris Group, ... exclusively for Okuma CNC machining centers at The International Manufacturing Technology Show, IMTS, ... companies with expertise in toolholding, cutting tools, machining dynamics and distribution, Velocity SMART ...
(Date:6/23/2016)... 2016 adds 2016 ... its pharmaceuticals section with historic and forecast data ... more. Complete report on the Cell ... 15 companies and supported with 261 tables and ... . The Global Cell Culture Media ...
Breaking Biology Technology: