Navigation Links
Researchers shine light on how stress circuits learn
Date:4/7/2013

Researchers at the University of Calgary's Hotchkiss Brain Institute have discovered that stress circuits in the brain undergo profound learning early in life. Using a number of cutting edge approaches, including optogenetics, Jaideep Bains, PhD, and colleagues have shown stress circuits are capable of self-tuning following a single stress. These findings demonstrate that the brain uses stress experience during early life to prepare and optimize for subsequent challenges.

The team was able to show the existence of unique time windows following brief stress challenges during which learning is either increased or decreased. By manipulating specific cellular pathways, they uncovered the key players responsible for learning in stress circuits in an animal model. These discoveries culminated in the publication of two back-to-back studies in the April 7 online edition of Nature Neuroscience, one of the world's top neuroscience journals.

"These new findings demonstrate that systems thought to be 'hardwired' in the brain, are in fact flexible, particularly early in life," says Bains, a professor in the Department of Physiology and Pharmacology. "Using this information, researchers can now ask questions about the precise cellular and molecular links between early life stress and stress vulnerability or resilience later in life."

Stress vulnerability, or increased sensitivity to stress, has been implicated in numerous health conditions including cardiovascular disease, obesity, diabetes and depression. Although these studies used animal models, similar mechanisms mediate disease progression in humans.

"Our observations provide an important foundation for designing more effective preventative and therapeutic strategies that mitigate the effects of stress and meet society's health challenges," he says.


'/>"/>

Contact: Marta
mcyperli@ucalgary.ca
403-210-3835
University of Calgary
Source:Eurekalert

Page: 1

Related biology news :

1. Cleveland Clinic researchers discover new link between heart disease and red meat
2. SFU researchers help unlock pine beetles Pandoras box
3. Empa researchers join Quantis to open new branch in Switzerland
4. MDC and FMP researchers identify edema inhibitor
5. Barrow researchers identify
6. Researchers discover brain cancer treatment using genetic material from bone marrow cells
7. Notre Dame researchers are using new technologies to combat invasive species
8. University of Montreal researchers discover how drug prevents aging and cancer progression
9. Researchers question evaluation methods for protected areas in the Amazon
10. Penn Researchers attach Lyme disease antibodies to nanotubes, paving way for diagnostic device
11. Researchers find novel mechanism regulating replication of insulin-producing beta cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... Press (OUP) is pleased to announce its new relationship ... 2015, OUP and CINP will partner to publish ... a fully open-access journal. , Alan Frazer, Editor-in-Chief of ... size and expertise of OUP will further facilitate the ... of the very leading journals within neuropsychopharmacology. The conversion ...
(Date:7/30/2014)... of $1 million from the Cornelia Cogswell Rossi Foundation ... Center. , The newly established Connie Cogswell ... develop a greater breadth and depth of knowledge of ... pace of research to improve human health. , The ... the Laboratory and its external partners, supporting research to ...
(Date:7/30/2014)... from HIV infection could be as simple as inserting ... , University of Washington bioengineers have discovered a potentially ... women from contracting HIV. Their method spins the drug ... with moisture, releasing higher doses of the drug than ... creams. , "This could offer women a potentially more ...
Breaking Biology News(10 mins):OUP to partner with the International College of Neuropsychopharmacology 2Rossi Foundation pledges $1M for JAX neurobehavioral research center 2Dissolvable fabric loaded with medicine might offer faster protection against HIV 2Dissolvable fabric loaded with medicine might offer faster protection against HIV 3
... not always show it, but people are rarely born with ... and legs to grow in the right places and point ... between our fingers and toes and every other formative detail ... to construct and position our limbs were being perfected more ...
... one strain of an infectious disease can exist at ... in the August issue of The American Naturalist, Ken ... mathematical model to help explain multiple strains, showing that ... that the coexistence of multiple infectious disease strains result ...
... could peer microscopically into the closest freshwater pond, you'd ... you'd probably notice an oddly furry, pear-shaped organism gliding ... This tiny predator has a big name-- Tetrahymena thermophila ... star organism for research into how cells work. , ...
Cached Biology News:UF scientists discover evolutionary origin of fins, limbs 2UF scientists discover evolutionary origin of fins, limbs 3What's shaped like a pear and has 2 genomes? Check the pond 2What's shaped like a pear and has 2 genomes? Check the pond 3
(Date:7/31/2014)... SoundConnect , an award winning ... to announce the addition of Adobe Connects Learning ... tools to quickly deploy and manage online courses ... for desktop and mobile learning solutions. , Adobe ... online training solution, enabling organizations to deploy, measure, ...
(Date:7/30/2014)... and PARIS , July 30, 2014 ... SAN and NYSE: SNY) today announced that the Companies ... (FDA) rare pediatric disease priority review voucher in connection ...  The priority review voucher entitles the holder to designate ... expedited 6-month review from the filing date instead of ...
(Date:7/30/2014)... 2014  Replikins Ltd. today released new data on ... Before the current outbreaks, the mean Ebola Reston gene ... between 1995 and 2002 was 1.1; the mean Replikin ... sixteen-fold in 2013, thus predicting the current outbreaks in ... been shown to be able to predict outbreaks (1). ...
(Date:7/30/2014)... 30, 2014 With the accelerated ... personal health expenditure as well as the improved ... China diagnostic reagent industry has been developing quickly, ... In 2013, Chinese in vitro diagnostics market size ... from in vitro diagnostic reagents. , Read ...
Breaking Biology Technology:SoundConnect Enhances Portfolio with Adobe Connect Learning Management System (LMS) 2Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 2Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 3Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 4Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 5Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 6China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 2China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 3
... call for making available more detailed maps of the locations ... crops on a county and township level will give researchers ... wildlife, water quality, and on pest and beneficial insects. ... been planted with biotech crops in the U.S.," said Michelle ...
... Corporation, an advanced,biomaterials company, announced today that ... AlloSource., (Logo: http://www.newscom.com/cgi-bin/prnh/20080424/NETH117LOGO ), ... Bone Matrix (DBM),powder to be mixed with ... form EquivaBone(TM)., This agreement is consistent ...
... 24 Idenix,Pharmaceuticals, Inc. (Nasdaq: IDIX ) ... overview at the upcoming Morgan Stanley Global,Healthcare Unplugged ... p.m.,ET at The Ritz Carlton in Key Biscayne, ... the company presentation can be,accessed under "Calendar of ...
Cached Biology Technology:Scientists call for more access to biotech crop data 2ETEX Announces Supply Agreement with AlloSource 2