Navigation Links
Researchers shine light on how stress circuits learn
Date:4/7/2013

Researchers at the University of Calgary's Hotchkiss Brain Institute have discovered that stress circuits in the brain undergo profound learning early in life. Using a number of cutting edge approaches, including optogenetics, Jaideep Bains, PhD, and colleagues have shown stress circuits are capable of self-tuning following a single stress. These findings demonstrate that the brain uses stress experience during early life to prepare and optimize for subsequent challenges.

The team was able to show the existence of unique time windows following brief stress challenges during which learning is either increased or decreased. By manipulating specific cellular pathways, they uncovered the key players responsible for learning in stress circuits in an animal model. These discoveries culminated in the publication of two back-to-back studies in the April 7 online edition of Nature Neuroscience, one of the world's top neuroscience journals.

"These new findings demonstrate that systems thought to be 'hardwired' in the brain, are in fact flexible, particularly early in life," says Bains, a professor in the Department of Physiology and Pharmacology. "Using this information, researchers can now ask questions about the precise cellular and molecular links between early life stress and stress vulnerability or resilience later in life."

Stress vulnerability, or increased sensitivity to stress, has been implicated in numerous health conditions including cardiovascular disease, obesity, diabetes and depression. Although these studies used animal models, similar mechanisms mediate disease progression in humans.

"Our observations provide an important foundation for designing more effective preventative and therapeutic strategies that mitigate the effects of stress and meet society's health challenges," he says.


'/>"/>

Contact: Marta
mcyperli@ucalgary.ca
403-210-3835
University of Calgary
Source:Eurekalert

Page: 1

Related biology news :

1. Cleveland Clinic researchers discover new link between heart disease and red meat
2. SFU researchers help unlock pine beetles Pandoras box
3. Empa researchers join Quantis to open new branch in Switzerland
4. MDC and FMP researchers identify edema inhibitor
5. Barrow researchers identify
6. Researchers discover brain cancer treatment using genetic material from bone marrow cells
7. Notre Dame researchers are using new technologies to combat invasive species
8. University of Montreal researchers discover how drug prevents aging and cancer progression
9. Researchers question evaluation methods for protected areas in the Amazon
10. Penn Researchers attach Lyme disease antibodies to nanotubes, paving way for diagnostic device
11. Researchers find novel mechanism regulating replication of insulin-producing beta cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... MONICA, Calif. , April 13, 2017 ... New York will feature emerging and evolving ... Summits. Both Innovation Summits will run alongside the expo ... of speaker sessions, panels and demonstrations focused on trending ... coast,s largest advanced design and manufacturing event will take ...
(Date:4/11/2017)... April 11, 2017 No two people ... at the New York University Tandon School of ... have found that partial similarities between prints are ... in mobile phones and other electronic devices can ... The vulnerability lies in the fact that fingerprint-based ...
(Date:4/5/2017)... , April 5, 2017 Today HYPR ... that the server component of the HYPR platform is ... providing the end-to-end security architecture that empowers biometric authentication ... HYPR has already secured over 15 million users across ... manufacturers of connected home product suites and physical access ...
Breaking Biology News(10 mins):
(Date:9/21/2017)... ... September 21, 2017 , ... ... sector professionals, has announced the addition of 5 new courses to its prospectus. ... Compliance with Regulation 21 CFR Part 11 on Electronic Records and Electronic Signatures ...
(Date:9/21/2017)... ... September 21, 2017 , ... Lajollacooks4u welcomed the San Diego chapter of Les ... society of professional women with high achievement in the fields of food, fine beverage ... , Twelve members began with an olive oil tasting to whet their palettes and ...
(Date:9/20/2017)... , ... September 20, 2017 , ... ... collaboration with Koch Agronomic Services (Koch) to feature new innovations aimed at helping ... broadcast first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. Check ...
(Date:9/20/2017)... ... ... Diversity focused business accelerator, The Refinery , announced today they are hosting ... technology-driven, women-led startups in Boston, MA, New Haven/Hamden, CT, and Newark, NJ. Fueling ... that week – in Boston, it will be part of the City of Boston's ...
Breaking Biology Technology: