Navigation Links
Researchers sequence dark matter of life
Date:9/18/2011

hers, recent studies have found, can change the way we behave by, for example, tricking us into eating more than we need. That's why it is crucial to analyze bacteria's genomes, which in turn help scientists understand bacteria's behavior.

Modern sequencing machines require DNA from one billion bacterial cells to produce a complete genome. Biologists usually grow the required amount of bacteria in cultures in the lab. That is how they obtained enough DNA to sequence E. coli. But a wide majority of bacteria99.9 percent according to some estimatescannot be cultured in the lab because they live in specific conditions and environments that are hard to reproduce, for example in symbiosis with other bacteria or on an animal's skin.

Enter Multiple Displacement Amplification (MDA) technology, developed about a decade ago by Professor Roger Lasken, now at the Venter Institute and co-author of the Nature Biotechnology study. MDA can be used on bacteria that can't be cultured in the lab. The technology is the equivalent of a copy machine that starts from a single cell and makes copies of fragments of its genome until it produces the equivalent of one billion cells. In 2005, Lasken and colleagues used MDA to sequence DNA produced from a single cell for the first time with funding from the Department of Energy.

However, while MDA is an ingenious cellular copy machine, it gives sequencing software programs a hard time. The DNA copies that MDA makes carry various errors and are not amplified uniformly: some pieces of the genome are copied thousands of times, and others only once or twice. Modern sequencing algorithms aren't equipped to deal with these disparities. In fact, they tend to discard bits of the genome that were replicated only a few times as sequencing errors, even though they could be key to sequencing the whole genome. The algorithm developed by Pevzner's team changes that. It retains these genome pieces and uses them to improve seq
'/>"/>

Contact: Ioana Patringenaru
ipatrin@ucsd.edu
858-822-0899
University of California - San Diego
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers sequence dark matter of life
(Date:8/4/2015)... , Aug. 04, 2015 ... ) has announced the addition of the ... Software, and Service), Sub-Segment (Computer Forensics, Network ... Tool Types, Service, Vertical and Region - ... their offering. By Component (Hardware, ...
(Date:7/31/2015)... , Kina, 31. juli 2015 Den 10. ... afholdt af BGI fra den 22. - 25. oktober i ... Konferencen fejrer sin 10-års fødselsdag i år. Siden starten ... indflydelsesrige årlige møder på ,omik,-feltet, og er en af ... ICG-10 fokuserer på nylige gennembrud og fremskridt ...
(Date:7/31/2015)... Chine, 31 juillet 2015 La 10e ... ) sera organisée par le BGI du 22 ... en Chine. La conférence ... inauguration en 2006, l,ICG est devenue l,une des ... domaine des « omiques » et c,est aussi la plus ...
Breaking Biology News(10 mins):Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3
... University of Washington (UW) researchers have successfully developed a ... of possible gene-disease links. By saving time and lowering ... search for disease-causing genes in people with the same ... other. The strategy also might be extended ...
... researcher in the College of Sciences, Department of Biology at ... strides in a project that was funded one year ago ... the South Texas Center for Emerging Infectious Diseases is researching ... health of military personnel in the Middle East and can ...
... St. Jude Children,s Research Hospital have identified inherited variations in ... lymphoblastic leukemia (ALL), including a gene that may help predict ... search of the human genetic blueprint or genome to look ... cancer. Published in the August 16 advance online issue of ...
Cached Biology News:Faster, cheaper way to find disease genes in human genome passes initial test 2Faster, cheaper way to find disease genes in human genome passes initial test 3UTSA biology researchers demystify elusive war zone bacterium 2Inherited risk factors increase odds of developing childhood acute lymphoblastic leukemia 2Inherited risk factors increase odds of developing childhood acute lymphoblastic leukemia 3
(Date:8/28/2015)... Research and Markets ( ... "Global & USA BioSimilar Market Analysis to 2021" ... US Biosimilar market will be initiated in September as ... will the global market react? Will biosimilars explode into ... save the US economy up to $250 billion within ...
(Date:8/28/2015)... August 28, 2015 According to ... Sera, Cryogenic Storage Systems, Thawing Equipment, Alarms), by Biospecimen ... Clinical Trials), End User - Global Forecast to 2020", ... to reach USD 3,731.03 Million by 2020 from USD ... 11.65% between 2015 and 2020. Browse ...
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... ... Personalized Medicine, presented two studies at the International Spine Intervention Society’ ... 28th, 2015 through to August 1st, 2015. With a focus on evidence-based research ...
(Date:8/28/2015)... ... August 28, 2015 , ... Pittcon is pleased to announce ... session on chemical spectroscopic imaging at JASIS 2015 (Japan Analytical & Scientific Instruments ... and scientific instruments show which will be held at International Conference Hall in ...
Breaking Biology Technology:Global & USA BioSimilar Market Analysis Report 2015-2021 2Global & USA BioSimilar Market Analysis Report 2015-2021 3Biopreservation Market Worth 3,731.03 Million USD by 2020 2Biopreservation Market Worth 3,731.03 Million USD by 2020 3Biopreservation Market Worth 3,731.03 Million USD by 2020 4Biopreservation Market Worth 3,731.03 Million USD by 2020 5Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 2Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 3Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 4U.S. Symposium on Imaging Organized by Pittcon’s Program Chairman Chuck Gardner 2U.S. Symposium on Imaging Organized by Pittcon’s Program Chairman Chuck Gardner 3
... , SEATTLE, Nov. ... CTIC) announced today that its new class of platinum-based ... and activity compared to currently available platinum-based compounds as ... cell lines. The results were presented in a ...
... ... ApaTech, the rapidly growing,orthobiologics company, was named Europe,s fastest growing,Biotech/Pharmaceutical/Medical ... (Europe, Middle East and Africa). , ... growth,for which ApaTech has achieved a rate of 8,318% over ...
... ... Change (NACCC) through its Second National Communication (SNC) Project in collaboration with the Vanuatu ... sea level rise results that will form the background for the country’s SNC reporting ... ...
Cached Biology Technology:New Class of Platinum-Based Anti-Tumor Drugs, Bisplatinates, Demonstrates Potent Anti-Tumor Activity and Ability to Overcome Resistance to Currently Available Platinum-Based Agents 2New Class of Platinum-Based Anti-Tumor Drugs, Bisplatinates, Demonstrates Potent Anti-Tumor Activity and Ability to Overcome Resistance to Currently Available Platinum-Based Agents 3ApaTech is Europe's Fastest Growing Lifescience Company 2ApaTech is Europe's Fastest Growing Lifescience Company 3ApaTech is Europe's Fastest Growing Lifescience Company 4Preliminary Climate and Sea Level Changes for Vanuatu Through the Application of SimCLIM 2Preliminary Climate and Sea Level Changes for Vanuatu Through the Application of SimCLIM 3Preliminary Climate and Sea Level Changes for Vanuatu Through the Application of SimCLIM 4
Complete cell culture media with cytokines...
Contains 0.2 g/L EDTA4Na in phosphate-buffered saline....
MHC Volumes 1 & 2...
Vertical Rack (five box vapor phase rack), includes 2.0" (5.1cm) boxes...
Biology Products: