Navigation Links
Researchers reveal the clearest new pictures of immune cells
Date:7/23/2013

Scientists from The University of Manchester have revealed new images which provide the clearest picture yet of how white blood immune cells attack viral infections and tumours.

They show how the cells, which are responsible for fighting infections and cancer in the human body, change the organisation of their surface molecules, when activated by a type of protein found on viral-infected or tumour cells.

Professor Daniel Davis, who has been leading the investigation into the immune cells, known as natural killers, said the work could provide important clues for tackling disease.

The research reveals the proteins at the surface of immune cells are not evenly spaced but grouped in clusters - a bit like stars bunched together in galaxies.

Professor Davis, Director of Research at the Manchester Collaborative Centre for Inflammation Research (MCCIR), a partnership between the University and two pharmaceutical companies GlaxoSmithKline and Astra Zeneca, said: "This is the first time scientists have looked at how these immune cells work at such a high resolution. The surprising thing was that these new pictures revealed that immune cell surfaces alter at this scale the nano scale which could perhaps change their ability to be activated in a subsequent encounter with a diseased cell.

"We have shown that immune cells are not evenly distributed as once thought, but instead they are grouped in very small clumps a bit like if you were an astronomer looking at clusters of stars in the Universe and you would notice that they were grouped in clusters.

"We studied how these clusters or proteins change when the immune cells are switched on to kill diseased cells. Looking at our cells in this much detail gives us a greater understanding about how the immune system works and could provide useful clues for developing drugs to target disease in the future."

Until now the limitations of light microscopy have prevented a clear understanding of how immune cells detect other cells as being diseased or healthy.

The team used high quality, super-resolution fluorescence microscopy to view the cells in blood samples in their laboratory to create the still images published in the journal Science Signalling this week.


'/>"/>

Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-172-58383
University of Manchester
Source:Eurekalert

Related biology news :

1. Researchers describe potential for MERS coronavirus to spread internationally
2. U of M researchers identify new functions for autoimmune disease risk gene
3. Solving DNA puzzles is overwhelming computer systems, researchers warn
4. Antiviral enzyme contributes to several forms of cancer, University of Minnesota researchers say
5. Carnegie Mellon researchers develop artificial cells to study molecular crowding and gene expression
6. Researchers perform DNA computation in living cells
7. Memorial Sloan-Kettering researchers develop new method for tracking cell signaling
8. Researchers create method to rapidly identify specific strains of illness
9. Stanford researchers say peak oil concerns should ease
10. MU researchers find condition in dogs that may help further research into human disease
11. OU researchers receive OCAST awards for health research projects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... May 16, 2017   Bridge Patient Portal ... and MD EMR Systems , an electronic ... for GE, have established a partnership to build ... and the GE Centricity™ products, including Centricity Practice ... These new integrations will allow healthcare ...
(Date:4/17/2017)... MELBOURNE, Florida , April 17, 2017 ... security technology company, announces the filing of its 2016 Annual Report ... Securities and Exchange Commission. ... Report on Form 10-K is available in the Investor Relations section ... well as on the SEC,s website at http://www.sec.gov . ...
(Date:4/11/2017)... , April 11, 2017 No two ... researchers at the New York University Tandon School ... Engineering have found that partial similarities between prints ... used in mobile phones and other electronic devices ... The vulnerability lies in the fact that ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... BOSTON (PRWEB) , ... October 12, 2017 , ... ... name for two-dimensional representations of a complex biological network, a depiction of a ... a big mess,” said Dmitry Korkin, PhD, associate professor of computer science at ...
(Date:10/12/2017)... ... October 12, 2017 , ... BioMedGPS announces ... addition of its newest module, US Hemostats & Sealants. , SmartTRAK’s US Market ... hemostats, fibrin sealants, synthetic sealants and biologic sealants used in surgical applications. BioMedGPS ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... gene in its endogenous context, enabling overexpression experiments and avoiding the use of ... small RNA guides is transformative for performing systematic gain-of-function studies. , This ...
(Date:10/11/2017)... -- VMS BioMarketing, a leading provider of patient support solutions, has ... (CNE) network, which will launch this week. The VMS CNEs ... professionals to enhance the patient care experience by delivering peer-to-peer ... care professionals to help women who have been diagnosed and ... ...
Breaking Biology Technology: