Navigation Links
Researchers reveal structure of protein that repairs damage to cancer cells
Date:4/23/2008

d DNA. They failed because this family of proteins binds DNA weakly, which foils the application of traditional crystallographic methods, He said. His team reinforced the complex by cross-linking the DNA to the protein.

Previous crystal structures of this protein included only a very short, single-stranded segment of DNA, and did not reveal all of its interactions with larger, more biologically relevant strands of DNA.

The technique that they used to grow these crystals is very clever, said Rice, who served as the teams crystallographer. Its a nice application of chemistry to solving important questions in biology.

Knowing which pieces of the enzyme are important for interacting with double-stranded DNA and which pieces are missing when it would prefer a single strand will help us to predict the functions of related proteins, Rice said.

Said He: Were now applying this same strategy to all kinds of other protein-DNA complexes.

The AlkB and ABH2 proteins repair alkylation damage to DNA, including the damage caused by alkylating cancer treatments. Alkylation is the addition of certain chemical groups to DNA and is particularly harmful to rapidly growing cells such as cancerous ones.

In an unexpected development last year, a team of European researchers published studies that identified an obesity gene in humans that belongs to the same family of proteins as AlkB. A defect in this gene, FTO, is associated with a weight gain of nearly seven pounds.

Its surprising and exciting to see that the demethylation function is linked to obesity, He said. Methylation is a type of alkylation that is used to regulate gene expression. One of his future goals is to determine the function of the FTO protein.

Among their many functions, proteins control chemical reactions in the cell by turning genes off and on. This family of proteins might use demethylation as a signal to regulate gene activation, he said. But this
'/>"/>

Contact: Steve Koppes
s-koppes@uchicago.edu
773-702-8366
University of Chicago
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Purdue researchers propose way to incorporate deforestation into climate change treaty
2. Fox Chase researchers discover a method for clamping down on a cancer-promoting enzyme
3. FISH-BOL: NOAA researchers help build a global reference library of DNA barcodes
4. Researchers uncover details about how dietary restriction slows down aging
5. Researchers discover critical detail of cellular defense against genetic mistakes
6. Researchers bridge the terahertz gap with new tunable metamaterial
7. NIST, Army researchers pave the way for anthrax spore standards
8. Researchers mimic bacteria to produce magnetic nanoparticles
9. Vitamin D and calcium influence cell death in the colon, researchers find
10. UD researchers discover novel gene toggles in worlds top food crop
11. Pitt and University of Chicago researchers uncover process behind heart muscle contraction
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers reveal structure of protein that repairs damage to cancer cells
(Date:12/17/2014)... 2014 Valencell, a leader in performance biometric data ... industry leaders such as Intel, Jabra, Atlas, and Scosche ... products. These products will be showcased at CES 2015, ... . "Our partners choose PerformTek ...
(Date:12/15/2014)... Markets ( http://www.researchandmarkets.com/research/87pph8/global_facial ) has announced the ... report to their offering. ... technology used for the identification of individuals. Facial recognition ... such as nose, jaw edges, mouth, and the distance ...
(Date:12/11/2014)... , Dec. 10, 2014  That blood pressure plays a ... while. Hypertension – the medical term for high blood pressure ... 1800s, and the inflatable cuff that,s used in measuring blood ... mean there,s nothing new about hypertension, its triggers and its ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... Energy. This trio of problems is among ... Water purification alone is becoming more problematic in ... sources, such as polluted rivers, lakes and groundwater. , ... Rittmann, director of the Center for Environmental Biotechnology in ...
... Fruit lovers worldwide may soon enjoy new, healthier, tastier ... data which fruit breeders say will help revolutionise the ... fruit science company HortResearch, announced today that they would ... collection of apple DNA sequences. , The release comprises ...
... the Max Planck Institute for Dynamics and Self-Organization ... Göttingen together with the neurophysiologist Maxim Volgushev from ... the nerve cells in the cerebral cortex decide ... that the high flexibility and speed with which ...
Cached Biology News:Earth Rx: A microbial biotechnology prescription for global environmental health 2Earth Rx: A microbial biotechnology prescription for global environmental health 3HortResearch science reveals the natural potential of apples 2Why nerve cells work faster than the theory allows 2Why nerve cells work faster than the theory allows 3Why nerve cells work faster than the theory allows 4
(Date:1/22/2015)...  Transwestern | RBJ today announces the firm brokered a long-term ... a leading biopharmaceutical company, at Two Ledgemont Center in ... Richards , president, and Brian Cohen , senior vice ... building at 95 Hayden Ave. Photo - ...
(Date:1/22/2015)... 2015 Protocol Networks brings independent technology ... of brand-neutral, independent consultants, Protocol Networks has recently announced ... over the years, his company has attracted several clients ... Plainfield, as well as others. With the success of ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Controlled Substance ... Alliance, which helps companies check the legal requirements around ... expand to China. , As their international operations ... globally adopting software solutions built as a result of ...
(Date:1/22/2015)... Jan. 22. 2015  Varian Medical Systems (NYSE: VAR ... honored for its commitment to sustainability with inclusion on a ... the highest ranked healthcare equipment company among the Corporate Knights ... World Economic Forum at Davos, Switzerland . ...
Breaking Biology Technology:Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Global Compliance Service for Controlled Substances to Expand to China 2Varian Honored Among World's 100 Most Sustainable Corporations 2
... /PRNewswire/ - Cytochroma today announced that it has appointed ... Company,s Scientific Advisory Board. , Dr. Cunningham is Professor ... Consultant Nephrologist at the Royal Free Hospital, London. His ... postgraduate training in The University of London and ...
... Oct. 15 /PRNewswire-Asia/ -- Sundia MediTech, a leading,pharmaceutical R&D ... D. Maher has been appointed Senior Vice President of ... Prior to joining Sundia, Mr. Maher was Executive Vice ... Group, a CRO company in,Florida, USA. Azopharma,s CRO ...
... Calif., Oct. 15 BlueFire Ethanol Fuels, Inc. (OTC ... world,s transportation fuel paradigm through the production of ethanol ... of its second planned biorefinery to Fulton, Mississippi. ... , After having been awarded a $40 million dollar ...
Cached Biology Technology:Cytochroma Appoints Dr. John Cunningham to its Scientific Advisory Board 2Cytochroma Appoints Dr. John Cunningham to its Scientific Advisory Board 3Sundia Appoints Charles D. Maher as Senior Vice President of Sales and Marketing 2Department of Energy Grants BlueFire Approval for Site Change 2Department of Energy Grants BlueFire Approval for Site Change 3Department of Energy Grants BlueFire Approval for Site Change 4
... the first fully automated proteomics workcell. It ... with complete data tracking. It automates the ... through final protein expression and measurement. The ... a plate to any of its instruments ...
... columns is a well-known separation technique in ... are in DNA/RNA extraction in microbiology, viral ... in chemical or analytical laboratories. ,This ... series instruments for smaller scales. The extraction ...
... multi-functional program that searches for ... sequence file for polymerase chain ... mutagenesis, and various hybridization applications. ... secondary structure of oligonucleotides based ...
... structure visualization, phylogenetic tree building, sequence analysis, ... application. Retrieve sequences ... filter them in real-time Organize your ... filtering and sorting Provides up-to-date articles ...
Biology Products: