Navigation Links
Researchers reveal structure of protein that repairs damage to cancer cells

d DNA. They failed because this family of proteins binds DNA weakly, which foils the application of traditional crystallographic methods, He said. His team reinforced the complex by cross-linking the DNA to the protein.

Previous crystal structures of this protein included only a very short, single-stranded segment of DNA, and did not reveal all of its interactions with larger, more biologically relevant strands of DNA.

The technique that they used to grow these crystals is very clever, said Rice, who served as the teams crystallographer. Its a nice application of chemistry to solving important questions in biology.

Knowing which pieces of the enzyme are important for interacting with double-stranded DNA and which pieces are missing when it would prefer a single strand will help us to predict the functions of related proteins, Rice said.

Said He: Were now applying this same strategy to all kinds of other protein-DNA complexes.

The AlkB and ABH2 proteins repair alkylation damage to DNA, including the damage caused by alkylating cancer treatments. Alkylation is the addition of certain chemical groups to DNA and is particularly harmful to rapidly growing cells such as cancerous ones.

In an unexpected development last year, a team of European researchers published studies that identified an obesity gene in humans that belongs to the same family of proteins as AlkB. A defect in this gene, FTO, is associated with a weight gain of nearly seven pounds.

Its surprising and exciting to see that the demethylation function is linked to obesity, He said. Methylation is a type of alkylation that is used to regulate gene expression. One of his future goals is to determine the function of the FTO protein.

Among their many functions, proteins control chemical reactions in the cell by turning genes off and on. This family of proteins might use demethylation as a signal to regulate gene activation, he said. But this

Contact: Steve Koppes
University of Chicago

Page: 1 2 3

Related biology news :

1. Purdue researchers propose way to incorporate deforestation into climate change treaty
2. Fox Chase researchers discover a method for clamping down on a cancer-promoting enzyme
3. FISH-BOL: NOAA researchers help build a global reference library of DNA barcodes
4. Researchers uncover details about how dietary restriction slows down aging
5. Researchers discover critical detail of cellular defense against genetic mistakes
6. Researchers bridge the terahertz gap with new tunable metamaterial
7. NIST, Army researchers pave the way for anthrax spore standards
8. Researchers mimic bacteria to produce magnetic nanoparticles
9. Vitamin D and calcium influence cell death in the colon, researchers find
10. UD researchers discover novel gene toggles in worlds top food crop
11. Pitt and University of Chicago researchers uncover process behind heart muscle contraction
Post Your Comments:
Related Image:
Researchers reveal structure of protein that repairs damage to cancer cells
(Date:3/24/2015)... March 24, 2015   NexID Biometrics LLC, ... security-authentication needs, today announced the beginning of shipments of ... The company, based in Potsdam, ... three-day Connect:ID Expo, which began here today at the ... version 2.0 of its SDK boosts the accuracy rate ...
(Date:3/23/2015)... -- SoundView Technology Group issues a new research update following ... smart wallet. SoundView was one of the selected user groups to ... Wocket in multiple scenarios and outlets. Soundview ... making both debit and credit card payments.  ... company meets their plans in 2015, it would push our ...
(Date:3/23/2015)... -- In the 2014 fiscal year, recorded over $100 ... accounts for a fraction of the estimated losses for ... $11 billion globally. The polygraph has traditionally been used ... Investor Mark Saint Juste along with former ... partnered to administer the test in a new way: ...
Breaking Biology News(10 mins):NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
... robotics technology make it possible to create prosthetics that ... capability promises to dramatically improve the mobility of lower-limb ... uneven ground, significantly reducing their risk of falling as ... bodies. That is the view of Michael Goldfarb, ...
... conditions such as current directions and water temperature play ... migrating salmon as they move from rivers and hit ... research. The findings inform restoration policies and practices focused ... The findings, from ecologists at the Department of ...
... often think about it, fluid dynamics touches almost every aspect ... flag, to swirling river currents that shape canyons to the ... of bodily functions -- urination -- is governed primarily by ... at the American Physical Society (APS) Division of Fluid Dynamics ...
Cached Biology News:Robotic advances promise artificial legs that emulate healthy limbs 2Robotic advances promise artificial legs that emulate healthy limbs 3Robotic advances promise artificial legs that emulate healthy limbs 4Tracking young salmon's first moves in the ocean 2Tracking young salmon's first moves in the ocean 3Tracking young salmon's first moves in the ocean 4The Tao of pee 2
(Date:4/27/2015)... 27, 2015 SynGen Inc., a company that ... that harvest stem and progenitor cells from umbilical cord ... today that it has added three new members to ... Blood Business Units focus on product commercialization. ... its Vice President and Chief Financial Officer.  Chuck was ...
(Date:4/27/2015)... tru Shrimp™ Systems announced today that it has ... the exclusive worldwide rights to commercialize Tidal Basin™ technology, ... agreement for the patented technology, developed by world-renowned shrimp ... China, Taiwan, France, Germany, Italy, Spain, the Netherlands and ... from all over the world for our Tidal Basin™ ...
(Date:4/24/2015)... April 24, 2015 Top student social ... San Diego area universities, including UCSD and SDSU, will ... from prominent local, national and nonprofit companies for an ... 5th Annual Social Innovation Challenge 2015 . , ... social venture ideas addressing a diverse range of issues ...
(Date:4/24/2015)... DIEGO , April 24, 2015  Pfenex Inc. ... the development of biosimilar therapeutics including high value and ... its follow-on public offering of 6,000,000 shares of its ... $15.50 per share. Of the shares being offered, 2,610,000 ... shares are being offered by existing stockholders. Pfenex will ...
Breaking Biology Technology:SynGen Inc. Expands Its Management Team 2tru Shrimp™ Systems Acquires Global Patent for Tidal Basin™ Shrimp Production 25th Annual Social Innovation Challenge at University of San Diego - Students Pitch to Live Judging Panel to Take Home $75K 25th Annual Social Innovation Challenge at University of San Diego - Students Pitch to Live Judging Panel to Take Home $75K 3Pfenex Inc. Announces Pricing Of Follow-on Offering 2
... hearings on affordable Internet access for all Chicagoans by Mayor ... ,Hopefully, what the council will get out of the testimony ... network infrastructure is as basic to supporting the city's growth ... today. , ,Some view this council as a "make ...
... Gov. Jim Doyle today proposed a joint public-private ... the development of renewable energy programs in Wisconsin. , ... low-interest loans, and grants that would come from business ... - would leverage an additional $370 million in private ...
... Eau Claire, Wis. - Two companies, including an ... Own Business" contest sponsored by the Eau Claire ... micro business and emerging-growth categories, respectively, were STAGE5, LLC, ... software, and, Inc ., a producer of ...
Cached Biology Technology:Chicago's Wi-Fi inertia harms business 2Chicago's Wi-Fi inertia harms business 3Chicago's Wi-Fi inertia harms business 4Doyle announces $80M renewable energy strategy 2Doyle announces $80M renewable energy strategy 3Doyle announces $80M renewable energy strategy 4Eau Claire business contest honors tech start ups 2
... Captivate magnetic separator for ... used in conjunction with the ... C-21476) or other magnetic particles ... 96-well microplates. Cell Biology Cell ...
Biology Products: