Navigation Links
Researchers reveal structure of protein that repairs damage to cancer cells
Date:4/23/2008

A team of University of Chicago scientists has shown how two proteins locate and repair damaged genetic material inside cells.

One protein detects and repairs damage in malignant cells that may result from a certain type of cancer therapy. In a paper published in the April 24 issue of the journal Nature, the team raised the possibility of designing a molecule that could interfere with the repair process, making cancer treatment more effective.

Chuan He, Assistant Professor in Chemistry, led the team. His co-authors included Phoebe Rice, Associate Professor in Biochemistry and Molecular Biology at the University of Chicago, and five researchers from his laboratory: Cai-Guang Yang, Chengqi Yi, Erica Duguid, Christopher Sullivan, and Xing Jian. Their work was supported by the National Institutes of Health, the W.M. Keck Foundation and the Arnold and Mabel Beckman Foundation.

In their Nature paper, the scientists determined, for the first time, the crystal structures (showing the three-dimensional framework of atoms) of two related DNA-repair proteins bound to double-stranded DNA: a bacterial protein called AlkB, and a corresponding human protein, ABH2. Scientists had been seeking the structures of these proteins to better understand how they perform their key roles in repairing DNA.

The bacterial protein can bind to either single- or double-stranded DNA. The strands separate during the replication process, but the bacterial protein avoids the latter. This is very bizarre, because most other DNA repair proteins prefer double-stranded, He said. The AlkB protein avoids double-stranded DNA because binding it takes more energy.

Double-stranded DNA is rigid. Single-stranded is very flexible, He explained. You can cause all kinds of distortion in single-stranded without paying much energetic penalty.

Many labs have unsuccessfully attempted to solve the structure of the bacterial protein with double-strande
'/>"/>

Contact: Steve Koppes
s-koppes@uchicago.edu
773-702-8366
University of Chicago
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Purdue researchers propose way to incorporate deforestation into climate change treaty
2. Fox Chase researchers discover a method for clamping down on a cancer-promoting enzyme
3. FISH-BOL: NOAA researchers help build a global reference library of DNA barcodes
4. Researchers uncover details about how dietary restriction slows down aging
5. Researchers discover critical detail of cellular defense against genetic mistakes
6. Researchers bridge the terahertz gap with new tunable metamaterial
7. NIST, Army researchers pave the way for anthrax spore standards
8. Researchers mimic bacteria to produce magnetic nanoparticles
9. Vitamin D and calcium influence cell death in the colon, researchers find
10. UD researchers discover novel gene toggles in worlds top food crop
11. Pitt and University of Chicago researchers uncover process behind heart muscle contraction
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers reveal structure of protein that repairs damage to cancer cells
(Date:4/23/2014)... Angeles, London (April 23, 2014). "I think one can argue ... pathwayas well as doing everything else that we canthen we ... Tom Wigley, one of the world,s foremost climate researchers, in ... , published by SAGE. Refusing to take significant action on ... eventually be needed to address the problem, Wigley explains in ...
(Date:4/22/2014)... team of Yale researchers will lead a five-year, $3 ... rain events is affecting the transport of dissolved organic ... they say could alter the chemical composition and water ... With funding from the National Science Foundation,s MacroSystems Biology ... across the watershed, which begins in Canada and runs ...
(Date:4/22/2014)... must be aware of the broad patent landscape and ... a new paper from Rice University,s Baker Institute for ... the journal Regenerative Medicine , the paper is ... in the case Association for Molecular Pathology (AMP) v. ... court case and rulings garnered discussion in the public ...
Breaking Biology News(10 mins):Is nuclear power the only way to avoid geoengineering? 2Connecticut River watershed study will assess impacts of extreme rain events 2Connecticut River watershed study will assess impacts of extreme rain events 3New patenting guidelines are needed for biotechnology 2New patenting guidelines are needed for biotechnology 3
... uterine fibroids and significantly relieves fibroid-related symptoms in ... clinical trial reported in the June issue of ... (MRgFUS) allows radiologists to precisely target fibroids without ... immediately stops blood flow in the treated fibroid ...
... University of Toronto researchers have uncovered the basis by ... also discovered how the HIV virus works to counteract ... for pregnant women in malaria-ravished regions. , Malaria is ... than one million people every year. While the disease ...
... of smell, which in many species is critical for finding ... biologists, sharks can not use just their noses to locate ... called the lateral line. The lateral line is an organ ... and vibration in the surrounding water. According to the research ...
Cached Biology News:Focused ultrasound relieves fibroid symptoms in women 2HIV and malaria combine to adversely affect pregnant women and their infants 2New research shows sharks use their noses and bodies to locate smells 2New research shows sharks use their noses and bodies to locate smells 3
(Date:1/15/2014)... ­ RedBrick Health , a fast-growing leader in ... that EmblemHealth , the New York ... providing the RedBrick Compass health assessment, combined with the ... its members. EmblemHealth is among the first health plans ...
(Date:1/15/2014)... Rochester, NY (PRWEB) January 15, 2014 The ... cause a major disease. One of these latent viruses is ... is rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... the theory, a study found that RA patients have high ...
(Date:1/15/2014)... , Jan. 15, 2014 TaiGen Biotechnology Company, Limited ... agreement with R-Pharm, a leading Russian pharmaceutical company, to ... Russian Federation , Turkey ... States (CIS). Nemonoxacin is a novel antibiotic for the treatment ...
(Date:1/14/2014)... 2014 As pet owners drew up their lists of New ... "Take better care of my furry companion." Nowadays there are pet ... carrying cases to take the little canine or feline darlings along ... to buy some pricey toys at the pet store. But anyone ...
Breaking Biology Technology:EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2
... it expands ... line of predictive diagnostic tests, EMERYVILLE, Calif., Sept. ... acquired Lipomics Technologies of West,Sacramento, Calif. The acquisition will ... terms were not disclosed., The acquisition brings together ...
... 17 Amicus Therapeutics,(Nasdaq: FOLD ), today announced ... make a presentation at the UBS Global Life Sciences,Conference ... in New York., An audio webcast of the ... http://www.amicustherapeutics.com . Participants should allow,approximately five to ten ...
... a finding that could speed the use of sensors or ... shown that certain types of tiny organic particles, when heated ... layer of a thin polymer film and then can reversibly ... , Selectively bringing a number of particles to a surface ...
Cached Biology Technology:Tethys Bioscience Announces Acquisition of Lipomics Technologies 2Tethys Bioscience Announces Acquisition of Lipomics Technologies 3NC State engineers discover nanoparticles can break on through 2
...
Experion HighSens chips are the microfluidic chips used to perform high-sensitivity RNA analysis (picogram levels) with the Experion automated electrophoresis system. Each chip has the capacity to ru...
... Second Mitochondria Derived Activator of ... 20 mM HEPES, pH 7.5 AVOID FREEZE/THAW CYCLES. ... Smac/DIABLO with a carboxy terminal His•Tag ® ... E. coli . Smac/DIABLO is released along with ...
... to Decorin ( Abpromise for ... Antigen: Synthetic peptide: IGPEVPDDRDFEPS conjugated ... 6-19 of Human Decorin (fragment 36-49 ... II). Entrez GeneID: ...
Biology Products: