Navigation Links
Researchers reveal new more precise method of performing electroconvulsive therapy
Date:5/6/2013

Philadelphia, PA, May 6, 2013 - Electroconvulsive therapy (ECT) is the most effective acute treatment for severe major depression. However, even with newer forms of ECT, there remains a significant risk of adverse cognitive effects, particularly memory problems.

Current theories hold that the regions that need to be stimulated to treat the depression (the cortex) are different and separate from the regions that result in memory problems (the hippocampus and temporal lobes). Theoretically, a more precise form of ECT could have all of the efficacy and few or none of the adverse cognitive side effects.

A new study published in Brain Stimulation now reports the initial clinical results of a novel form of precise ECT called FEAST (Focal Electrically Applied Seizure Therapy). This clinical trial in 17 depressed adults builds on earlier design work and animal testing done at Columbia University in NY. This new form of ECT uses pulsed direct current stimulation, with the bulk of the electrical charge being delivered directly under one electrode placed on the right orbital cortex, about 1 inch above the right eye. Traditional ECT uses alternating current, which flows in both directions and is thus harder to direct and target.

''We found, in this feasibility study, that FEAST produced clinically meaningful antidepressant improvements," said Dr. Ziad Nahas, first author of the research conducted jointly at the Medical University of South Carolina and Columbia University (NY). Dr. Nahas is now Department Chair at the America University in Beirut, Lebanon. "Importantly, the time it took for patients to be fully reoriented after the treatment was just 5 minutes from when they first opened their eyes. This orientation time traditionally corresponds to the cognitive side effects. This is much quicker than any other form of ECT, where the orientation time is much greater, sometimes up to or exceeding an hour."

Overall, the group had their depression symptoms almost reduced by half, after an average of 10 sessions over 4 weeks. Eight individual patients had at least a 50% reduction in their symptoms, and 5 remitted, meaning they were largely symptom free.

This was the first human use of FEAST, and the group is continuing to refine the method and test how it works using advanced brain imaging and electroencephalography (EEG).

Dr. Harold Sackeim, Professor of Psychiatry and Radiology at Columbia University and the early developer of the FEAST technique, commented, "These initial encouraging results suggest that one can perfect and refine ECT with a more focal delivery system like FEAST. These are exciting confirmatory data in depressed patients building on what we found in earlier work."

"Further work is needed to see if we can improve the titration schedule, refine the dose, and make this into another, better, method of performing ECT," said Nahas.


'/>"/>

Contact: Donna Santaromita
Ed.santaromita@elsevier.com
212-633-3962
Elsevier
Source:Eurekalert

Related biology news :

1. Researchers calculate the global highways of invasive marine species
2. University of Maryland School of Medicine researchers find potential novel treatment for influenza
3. Researchers pinpoint upper safe limit of vitamin D blood levels
4. Researchers track singing humpback whales on a Northwest Atlantic feeding ground
5. Huddersfield researchers publish a book exploring the link between evolution and criminal behavior
6. Researchers pinpoint how trees play role in smog production
7. CNIO researchers capture the replication of the human genome for the first time
8. Researchers abuzz over caffeine as cancer-cell killer
9. An important discovery in breast cancer by IRCM researchers
10. UCLA researchers find nanodiamonds could improve effectiveness of breast cancer treatment
11. Clues to heart disease in unexpected places, Temple researchers discover
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... Annual Report on Form 10-K on Thursday April 13, 2017 with ... ... Relations section of the Company,s website at http://www.nxt-id.com  under "SEC ... . 2016 Year Highlights: Acquisition ...
(Date:4/11/2017)... Research and Markets has announced the addition of the ... ... grow at a CAGR of 30.37% during the period 2017-2021. ... prepared based on an in-depth market analysis with inputs from industry ... over the coming years. The report also includes a discussion of ...
(Date:4/5/2017)...  The Allen Institute for Cell Science today announces ... portal and dynamic digital window into the human cell. ... application of deep learning to create predictive models of ... a growing suite of powerful tools. The Allen Cell ... publicly available resources created and shared by the Allen ...
Breaking Biology News(10 mins):
(Date:8/21/2017)... Arbor, MI (PRWEB) , ... August 21, 2017 ... ... Innovation Awards: Healthcare Edition 2017. The awards recognize medical centers that have implemented ... by their efficiency of patient care protocols, competitive advantages, financial impact/value, and market ...
(Date:8/21/2017)... ... August 21, 2017 , ... Today Aether announced that Aether and ... a Bill and Melinda Gates Foundation grant, to pursue a 3D ... Foundation, also known as the Gates Foundation, is said to be the largest transparently ...
(Date:8/17/2017)... CA (PRWEB) , ... August 17, 2017 , ... ... for cancer research and personalized medicine, today announced the launch of a new ... City, Missouri. The study’s goal is to evaluate the potential for early detection ...
(Date:8/16/2017)... PA (PRWEB) , ... August 16, 2017 , ... While ... they are much more closely connected than one might think. A Mesh Is ... will open at the University City Science Center’s Esther Klein Gallery (EKG) on August ...
Breaking Biology Technology: