Navigation Links
Researchers reveal a new pathway through the sodium pump
Date:3/31/2014

A study in The Journal of General Physiology provides new evidence that the ubiquitous sodium pump is more complexand more versatilethan we thought.

The sodium pump is present in the surface membrane of all animal cells, using energy derived from ATP to transport sodium and potassium ions in opposite directions across the cell boundary. By setting up transmembrane gradients of these two ions, the pump plays a vital role in many important processes, including nerve impulses, heartbeats, and muscular contraction.

Now, Rockefeller University researchers Natascia Vedovato and David Gadsby demonstrate that, in addition to its role as a sodium and potassium ion transporter, the pump can simultaneously import protons into the cell. Their study not only provides evidence of "hybrid" function by the pump, it also raises important questions about whether the inflow of protons through sodium pumps might play a role in certain pathologies.

The sodium pump exports three sodium ions out of the cell and imports two potassium ions into the cell during each transport cycle. Vedovato and Gadsby show that, during this normal cycle, the pump develops a passageway that enables protons to cross the membrane. When the pump releases the first of the three sodium ions to the cell exterior, a newly emptied binding site becomes available for use by an external proton, allowing it to then make its way into the cytoplasm. The protons travel a distinct route, and proton inflow is not required for successful transport of sodium and potassium.

Import of protons is high when their extracellular concentration is high (pH is low) and membrane potential is negative. The authors therefore speculate that proton inflow might have important implications under conditions in which extracellular pH is lowered, such as in muscle during heavy exercise, in the heart during a heart attack, or in the brain du
'/>"/>

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Researchers uncover secrets of a mollusks unique bioceramic armor
2. Scripps Florida scientists offer best practices nutrition measurement for researchers
3. Researchers identify new protein markers that may improve understanding of heart disease
4. Two researchers known for identifying and treating bubble boy disease honored by March of Dimes
5. Researchers at IRB discover a key regulator of colon cancer
6. Researchers reveal the dynamics behind Arctic ecosystems
7. IRCM researchers uncover a new function for an important player in the immune response
8. UGA researchers explore function of cancer-causing gene
9. Researchers present comprehensive roadmap of blood cells
10. UT Southwestern ob/gyn researchers studying genetic factors in premature births
11. Researchers issue state-of-the-state on genetic-based testing & treatment for breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers reveal a new pathway through the sodium pump
(Date:6/24/2015)... YORK , June 24, 2015 The ... rate. The major drivers for the market include growth ... number of new drug launches. Over the years, the ... increased. Between 2001 and 2010, the FDA approved 225 ... according to WIPO, Europe accounted ...
(Date:6/24/2015)... , June 24, 2015  Synaptics Inc. ... human interface solutions, today announced that Sharp has ... provide secure authentication for its latest flagship smartphone ... more than 200 million shipments of its fingerprint ... reinforces Synaptics, strength, scalability and leadership in the ...
(Date:6/24/2015)... , June 24, 2015 Biometry ... with emerging biometric password solution one face in. ... one face in, entering the ... ground-breaking and affordable multifactor-authentication biometric answer to the ... technology, provided in partnership with KeyLemon, one face ...
Breaking Biology News(10 mins):Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 3Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 4Synaptics Brings Natural ID Technology to Sharp's Newest Flagship Smartphone 2KeyLemon Announces Partnership With Biometric Password Solution onefacein 2
... a high-fat diet during pregnancy increases the chance of stillbirth, ... The new data show eating a typical American diet, which ... to the placenta, the temporary organ that nourishes the unborn ... contributes to stillbirth was unclear. The findings are published in ...
... PHILADELPHIA (June 2, 2011) -- Although bitterness can sometimes be ... chocolate more often bitter taste causes rejection that can ... especially true for children. Now, scientists from the Monell Center ... inhibits bitterness by acting directly on a subset of bitter ...
... agricultural sustainability in developing countries, but only with the ... networks they depend on, say Stanford University researchers. Their ... of the Proceedings of the National Academy of ... that technology information flows to farmers through a direct ...
Cached Biology News:Study reveals how high-fat diet during pregnancy increases risk of stillbirth 2New bitter blocker discovered 2Farmer networks hold key to agricultural innovation in developing countries, Stanford study finds 2
(Date:6/29/2015)... DALLAS , June 29, 2015 ... Type (DNA, RNA, XNA), by Application (Diagnostics, Therapeutics, R&D), by ... Biotechnology & Pharmaceutical Companies, CRO) - Global Forecast to 2020", ... reach $244.93 Million by 2020 from $107.56 Million in 2015, ... market T ables and 67 F ...
(Date:6/29/2015)... Elsevier , a world-leading provider of ... announced the highlights of its journal Impact Factor performance ... (JCR) published by Thomson Reuters, Elsevier saw 55% of ... ahead of the aggregate across other journals. In 2014, ... categories, up from 61 in 2013. An ...
(Date:6/26/2015)... ... June 26, 2015 , ... Charm Sciences, Inc. is pleased ... Stockyards Administration (GIPSA) awarded a five year contract to Charm Sciences to monitor ... ROSA DONQ-FAST5 Test. This 5 minute quantitative test extracts DON from samples using ...
(Date:6/26/2015)... 23, 2015 Research ... of the "Global Cancer Biosimilars Market Opportunity ... Market introduction of cancer biosimilar is required because ... Chemotherapeutic drugs have dominated the cancer segment for ... introduced in past few years. They are biologic ...
Breaking Biology Technology:Aptamers Market Worth $244.93 Million by 2020 2Aptamers Market Worth $244.93 Million by 2020 3Aptamers Market Worth $244.93 Million by 2020 4Elsevier Announces 2014 Citation Impact Highlights 2Elsevier Announces 2014 Citation Impact Highlights 3USDA-GIPSA (FGIS) Awards 5 Year Contract for Vomitoxin Tests to Charm Sciences 2Global Cancer Biosimilars Market Opportunity Outlook 2Global Cancer Biosimilars Market Opportunity Outlook 3
... have a number of juicy topics I wanted to review ... biotech/medical device conference (BIOMED 2006), recent participation in meetings about ... happenings in Japan, and other research that has crossed my ... on why I originally wanted to start writing this column. ...
... The remarkable rate of development in the information technology ... experts in the field. Staying astride the flow of ... professionals and students alike. , ,That is why IT ... and mutual assistance, especially when the goal is educating ...
... invented by University of Wisconsin-Madison engineers promise ... amazing array of materials. , ,Historically, the semiconductor ... to grow and etch the thin films of material ... devices. But as thin as those chips might seem, ...
Cached Biology Technology:The world of in-vitro diagnostics is another Midwest success story 2The world of in-vitro diagnostics is another Midwest success story 3The world of in-vitro diagnostics is another Midwest success story 4The world of in-vitro diagnostics is another Midwest success story 5The world of in-vitro diagnostics is another Midwest success story 6MATC boot camp keeps IT instructors up to date 2MATC boot camp keeps IT instructors up to date 3MATC boot camp keeps IT instructors up to date 4MATC boot camp keeps IT instructors up to date 5UW produces fast and flexible computer chip 2
... Amplification Kit, 100 reactions. Prepare circular ... 4-6 h.Generate microgram quantities of template ... material.Use amplified DNA directly for cycle ... or M13 liquid cultures, colonies, plaques, ...
Polypropylene test tube racks, used in Thermo Forma's line of Test Tube Rack holders...
For quantitative determination of Aldolase in Serum (an indicator of muscle damage). Ready-to-use liquid stable reagent. Formulated to eliminate interference from pyruvates. Application sheets are ...
This Universal 24" X 18" (61 X 45.7cm.) shaker platforms will accept any Thermo Forma shaker flask clip....
Biology Products: