Navigation Links
Researchers reveal HIV peptide's possible pathway into the cell
Date:1/17/2008

tion Professor of Biocomputation and Bioinformatics Angel Garcia. "The mechanism for entrance in the cell was clear in one simulation, but in some instances simulations show one result and you never see that result again. Then we started doing other simulations and it kept happening again and again."

Garcia and his collaborator, postdoctoral researcher Henry Herce, initially set out to uncover how the peptide interacts with a lipid bilayer that is used to model the cell membrane. A highly efficient biological system, the cell membrane is composed of a lipid bilayer (made up of two monolayers) designed to protect the cell by preventing the influx of material. Each lipid in the bilayer has a polar, or charged, end and a non-polar end. A monolayer of lipids faces the exterior of the cell, with the polar end facing the outside of the cell. Another monolayer is under the first layer, forming the bilayer. The polar end of the lower layer faces the interior of the cell, forming a middle section containing the uncharged halves of both monolayers.

Because charged particles seek each other in order to neutralize themselves and achieve a more stable state, the surface of the polar cell membrane and the positively charged HIV peptide are drawn to one another. But the interior of the bilayer is not charged and forms a strong barrier against the entrance of any charged material.

As was expected, in their simulations the researchers observed that the positive charges in the peptide quickly attached to the surface of the cell membrane and sought out and reacted with negatively charged phosphates from the charged portion of the lipid bilayer to satisfy their need for neutrality. "Then the peptide entered the forbidden territory of the cell," Garcia said. The positively charged peptide entered the membrane. "This is when this mechanism starts to challenge conventional wisdom," he said.

The researchers' model systems show the peptides grabbing for
'/>"/>

Contact: Gabrielle DeMarco
demarg@rpi.edu
518-276-6542
Rensselaer Polytechnic Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. USC researchers identify mechanism that controls activation of stem cells during hair regeneration
2. Researchers put the bite on mosquitoes
3. Researchers find association between food insecurity and developmental risk in children
4. Iowa State researchers look for smaller, cheaper, 1-dose vaccines
5. Japanese and German researchers meet to discuss climate change
6. Type 1 diabetes triggered by lazy regulatory T-cells: McGill researchers
7. Researchers uncover new piece to the puzzle of human height
8. Researchers create mathematical model of fruit fly eyes
9. Snoozing worms help Penn researchers explain the evolution of sleep
10. Researchers move 2 steps closer to understanding genetic underpinnings of autism
11. Rices West honored as one of Texas best researchers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers reveal HIV peptide's possible pathway into the cell
(Date:4/15/2014)... April 15, 2014, Irvine, Calif. UC Irvine neurobiologists ... positive results when transplanted into the brains of mice ... pre-clinical trial is published in the journal Stem ... been shown to work in two different mouse models. ... forms of dementia, is associated with accumulation of the ...
(Date:4/15/2014)... Hartford, Connecticut, a Puerto Rican community is creating a ... so authentic it has caught the attention of scientists. ... Anderson (University of Connecticut) took a close look at ... Hartford and uncovered evidence that gives new meaning to ... years: home is in the kitchen. , "Culinary preferences ...
(Date:4/15/2014)... as early as 2020 how high sea levels will ... of researchers including Florida International University scientist Rene Price. ... Foundation,s (NSF) Florida Coastal Everglades Long-Term Ecological Research (LTER) ... ecosystems from coral reefs to deserts, mountains to salt ... level rise is one of the most certain consequences ...
Breaking Biology News(10 mins):UCI study finds modified stem cells offer potential pathway to treat Alzheimer's disease 2The human food connection: A new study reveals more about our relationship to food 2The human food connection: A new study reveals more about our relationship to food 3Long-term predictions for Miami sea level rise could be available relatively soon 2
... University of Maryland Center for Environmental Science researchers gives ... Bay ecological conditions were slightly better than the previous ... healthy Bay. The Chesapeake Bay Health Report ... is nothing here from which we can take great ...
... Tyler J. and Frances F. Young Professor of Bacteriology ... the Virginia-Maryland Regional College of Veterinary Medicine at Virginia ... States Department of Agriculture to study the role biofilm ... (BRDC). The $374,000 grant will allow Inzana and ...
... bird feeders in their backyards each year, often out of ... survey of research on the topic finds that feeding may ... Published as a Frontiers in Ecology and the ... Gillian Robb (Queens University Belfast, UK) and by Stuart Bearhop ...
Cached Biology News:Chesapeake Bay ecosystem health remains poor, but slightly improved in 2007 2Veterinary college researchers explore function of biofilm in bovine respiratory disease 2Food for thought 2
(Date:1/15/2014)... 2014 The Microcompetition with Foreign DNA ... disease. One of these latent viruses is the Epstein ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... by the theory, a study found that RA patients ... (1). , What is Microcompetition? , Dr. Hanan ...
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... of high throughput research solutions, today announced that ... companies, has received delivery of Freeslate’s CM ... form screening. , Lupin, headquartered in Mumbai, ... quality, affordable generic and branded formulations and Active ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Date: Friday, ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, ... Foundation, the only national nonprofit organization solely dedicated to ... quality of life for those affected worldwide, will host ... Warrington Country Club in Warrington, Pa. , Each ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider ... major scientific, regulatory, business, and media events in ... , today announced its former associate Virginia Cox , ... office. Virginia Cox re-joins ... Commissioner for the Office of External Affairs at the U.S. ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2
... PHILADELPHIA, Oct. 29 GlaxoSmithKline (NYSE:,GSK) (LSE: GSK) ... announced,today that they have entered into a definitive ... approximately $57 million (pounds Sterling 35,million) through a ... This strategic,acquisition will strengthen GSK,s effort to develop ...
... BioAuthorize,Holdings, Inc. and its wholly owned ... high-tech voice biometric security company,providing online payment ... board of directors and restructured its executive ... implementation of its newly developed,biometric authentication services., ...
... Calif., Oct. 29 Sangamo,BioSciences, Inc. (Nasdaq: SGMO ... For the third quarter ended September 30, 2008, ... $0.15 per share, compared to a,net loss of $4.3 ... in 2007.,As of September 30, 2008, the company had ...
Cached Biology Technology:GlaxoSmithKline to Acquire Genelabs Technologies to Increase Focus on Novel Small Molecule Therapies for Hepatitis C 2GlaxoSmithKline to Acquire Genelabs Technologies to Increase Focus on Novel Small Molecule Therapies for Hepatitis C 3GlaxoSmithKline to Acquire Genelabs Technologies to Increase Focus on Novel Small Molecule Therapies for Hepatitis C 4BioAuthorize Holdings, Inc. Names New Directors and Executive and Unveils Modification to Its Voice Biometric Authentication Service 2BioAuthorize Holdings, Inc. Names New Directors and Executive and Unveils Modification to Its Voice Biometric Authentication Service 3BioAuthorize Holdings, Inc. Names New Directors and Executive and Unveils Modification to Its Voice Biometric Authentication Service 4BioAuthorize Holdings, Inc. Names New Directors and Executive and Unveils Modification to Its Voice Biometric Authentication Service 5Sangamo BioSciences Reports Third Quarter 2008 Financial Results 2Sangamo BioSciences Reports Third Quarter 2008 Financial Results 3Sangamo BioSciences Reports Third Quarter 2008 Financial Results 4Sangamo BioSciences Reports Third Quarter 2008 Financial Results 5Sangamo BioSciences Reports Third Quarter 2008 Financial Results 6Sangamo BioSciences Reports Third Quarter 2008 Financial Results 7
... combines a single-channel sample processing head, an ... reagent dispenser all in one compact, affordable ... pipette tips, the Precision XS autoclavable and ... available for transferring larger volumes. Intuitive Precision ...
... races ever faster, you need a partner who ... our constant focus is on providing tools and ... our Biomek 3000 Laboratory Automation Workstation offers a ... is flexible. By integrating all aspects of liquid ...
... Rabbit Tissue Arrays contain 60 rabbit tissue samples ... contains 4 unstained slides and 1 hematoxylin and ... slide contains 15 different tissues from 4 rabbit ... per slide. Each tissue sample (or core) is ...
... with a wide variety of purity levels, scales ... Purity: IG(>50%), >70%, >80% and ... Sequence Length: Up to 120 residues ... D-amino acids, MAPs, KLH/BSA conjugation, and much more. ...
Biology Products: