Navigation Links
Researchers reveal HIV peptide's possible pathway into the cell
Date:1/17/2008

Troy, N.Y. - Two theoretical physicists at Rensselaer Polytechnic Institute have uncovered what they believe is the long-sought-after pathway that an HIV peptide takes to enter healthy cells. The theorists analyzed two years of biocomputation and simulation to uncover a surprisingly simple mechanism describing how this protein fragment penetrates the cell membrane. The discovery could help scientists treat other human illnesses by exploiting the same molecules that make HIV so deadly proficient.

The findings are detailed in the Dec. 26, 2007, issue of the Proceedings of the National Academy of Sciences (PNAS).

For the last decade, scientists have known that a positively charged, 11-amino-acid chain of HIV (HIV-1 Tat protein) can do the nearly unthinkable X cross through the cell membrane. Sometimes referred to as an "arrow protein," HIV-1 Tat pierces the cell membrane and carries a cargo though the cell membrane.

Its unique cell-puncturing ability has been the subject of hundreds of scientific articles investigating the type of materials that can piggyback on the peptide and also enter the cell. Researchers have proposed using the peptide to deliver genes for gene therapy and drugs that need to be delivered directly to a cell. But despite many potential medical applications, the actual mechanism that opens the holes in the cell remained undiscovered.

The Rensselaer researchers have discovered that the positively charged HIV peptide is drawn to negatively charged groups inside the cell membrane. When the HIV peptide cannot satisfy itself with the negative charges available on the cell membrane surface it is directly attached to, it reaches through the membrane to grab negatively charged groups in the molecules on the other side, opening a transient hole in the cell.

"What we saw in our computer calculations wasn't at all what we expected to see when we began," said co-lead author and Senior Constella
'/>"/>

Contact: Gabrielle DeMarco
demarg@rpi.edu
518-276-6542
Rensselaer Polytechnic Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. USC researchers identify mechanism that controls activation of stem cells during hair regeneration
2. Researchers put the bite on mosquitoes
3. Researchers find association between food insecurity and developmental risk in children
4. Iowa State researchers look for smaller, cheaper, 1-dose vaccines
5. Japanese and German researchers meet to discuss climate change
6. Type 1 diabetes triggered by lazy regulatory T-cells: McGill researchers
7. Researchers uncover new piece to the puzzle of human height
8. Researchers create mathematical model of fruit fly eyes
9. Snoozing worms help Penn researchers explain the evolution of sleep
10. Researchers move 2 steps closer to understanding genetic underpinnings of autism
11. Rices West honored as one of Texas best researchers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers reveal HIV peptide's possible pathway into the cell
(Date:7/14/2014)... German . , ... development. One classical example is the sequential and rhythmic ... that has been linked to the ticking of an ... now, this patterning process was thought to be determined ... periodically trigger new segment formation. However, this week in ...
(Date:7/14/2014)... MedNet Solutions , a global ... management systems, is pleased to announce that ... on software-as-a-service (SaaS) and Internet-based businesses, has made ... funding, representing the first major outside financing in ... the ongoing growth and development of both MedNet ...
(Date:7/14/2014)... 14, 2014 Research and Markets has ... 2014: Applications for Microfluidic Technologies" report to their offering. ... testing based on microfluidic technology is expected to grow sharply, ... CAGR 2014 - 2019 of 23%. Major diagnostics companies (Alere, ... etc.) have realized the potential of rapid molecular diagnostic testing. ...
Breaking Biology News(10 mins):Timing is not only ticking 2Timing is not only ticking 3Arrowroot Capital Invests $4 Million In MedNet Solutions 2Arrowroot Capital Invests $4 Million In MedNet Solutions 3Applications for Microfluidic Technologies in Point of Care Testing: 2014 Report 2Applications for Microfluidic Technologies in Point of Care Testing: 2014 Report 3
... New evidence suggests that the risk of HIV transmission ... According to a study published in the April ... available online, early infection accounted for nearly half of ... province of Quebec, Canada. , Bluma Brenner, PhD, and ...
... Turn up the white noise, says a team of ... the benefits of noise. Their findings could lead to ... an assistant professor of computer science, Joseph Martin, a ... of biology, are working together to explain the biological ...
... no two brains are alike, they can display a ... sensory input. Scientists at the Max Planck Institute for ... mathematical method to design networks from neural cells which ... their method will assist them in getting closer to ...
Cached Biology News:Risk of HIV transmission highest early in infection 2Noise echoes in cell communications 22 brains -- 1 thought 22 brains -- 1 thought 3
(Date:7/14/2014)... TRIANGLE PARK, N.C. , July 14, 2014 ... focused on cloud-based drug design and development, announced ... development program. The company has been granted supercomputing ... of multiple parasitic targets.  Through ... the Argonne Leadership Computing Facility (ALCF), researchers at ...
(Date:7/14/2014)... July 14, 2014 Throughout this ... across the clinical trials space, representing 38 countries ... series entitled “Optimizing Patient Participation in Clinical Trials. ... off with internationally renowned R&D expert, Ken Getz, ... on Reinventing Drug Development through Patient Centricity. , ...
(Date:7/14/2014)... 14, 2014 Minerva Neurosciences (NASDAQ: ... therapies to treat neuropsychiatric diseases and disorders, today announced ... vice president of finance and chief accounting officer, effective ... senior executive with more than 20 years of experience ... science companies. His background includes the management of compliance ...
(Date:7/14/2014)... San Mateo, CA (PRWEB) July 14, 2014 ... groundbreaking CONNECT patient registry platform, announced that ... Becker muscular dystrophies; the Phelan-McDermid Syndrome International ... primary Nephrotic Syndrome—have been awarded contracts by ... part of the creation of a new ...
Breaking Biology Technology:Cloud Pharmaceuticals Granted 1M Hours of Supercomputer Time to Target Orphan Diseases Including Malaria 2Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 2Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 3Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 4Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 5Minerva Neurosciences Announces Appointment Of Frederick W. Ahlholm As VP Of Finance And Chief Accounting Officer 2PatientCrossroads Fuels Development of New National Clinical Research Network 2PatientCrossroads Fuels Development of New National Clinical Research Network 3
... Inc., the,leading developer of stents designed for the ... has closed a $14 million Series,C round of ... Venture,Partners joined with Spray Venture Partners in the ... RiverVest have been appointed to the Tryton,Board of ...
... blood pressure of elderly patients could cut their total,mortality ... by a third,according to a new study presented today ... simultaneously in the New England,Journal of Medicine., LONDON, ... Elderly Trial (HYVET), which is co-ordinated by scientists from,Imperial ...
... discover and develop ... SAN FRANCISCO, March 31 The Immune Tolerance Institute,Inc. ... a Center for Critical Path Immunology to investigate the role ... be managed by,ITI and located initially at Beckman Coulter,s Cellular ...
Cached Biology Technology:Tryton Medical, Inc. Closes $14 Million Financing 2Tryton Medical, Inc. Closes $14 Million Financing 3Significant Reductions in Mortality and Cardiovascular Events Shown Using Blood Pressure-Lowering Treatment in Those Aged 80 and Over 2Significant Reductions in Mortality and Cardiovascular Events Shown Using Blood Pressure-Lowering Treatment in Those Aged 80 and Over 3Significant Reductions in Mortality and Cardiovascular Events Shown Using Blood Pressure-Lowering Treatment in Those Aged 80 and Over 4The Immune Tolerance Institute Announces Collaboration with Beckman Coulter Establishing a Multiplatform Immunophenotyping/Immunogenotyping Laboratory 2The Immune Tolerance Institute Announces Collaboration with Beckman Coulter Establishing a Multiplatform Immunophenotyping/Immunogenotyping Laboratory 3
...
Human VEGF R Phycoerythrin Sampler (Cl 89106, 49560, 54733)...
... Beagle serum is collected from fasted Beagle canines ... Available Anticoagulants: N-02: Citrate ... K2EDTA N-08: Potassium Oxalate N-10: ... N-05: ACD N-07: CPD ...
... cDNA Purification Kit is designed to purify double-stranded ... cDNA synthesis and PCR. The process is simple ... to 3 g can be efficiently purified and ... 1) DNA is bound to the Microfilter Cartridge ...
Biology Products: