Navigation Links
Researchers report on the early development of anti-HIV neutralizing antibodies
Date:1/14/2011

New findings are bringing scientists closer to an effective HIV vaccine. Researchers from Seattle Biomedical Research Institute (Seattle BioMed), Vanderbilt University and the Ragon Institute of MGH, MIT and Harvard report findings showing new evidence about broadly-reactive neutralizing antibodies, which block HIV infection. Details are published January 13 in the open-access journal PLoS Pathogens.

According to author Leo Stamatatos, Ph.D., director of the Viral Vaccines Program at Seattle BioMed and a major stumbling block in the development of an effective vaccine against HIV is the inability to elicit, by immunization, broadly reactive neutralizing antibodies (NAbs). These antibodies bind to the surface of HIV and prevent it from attaching itself to a cell and infecting it. However, a fraction of people infected with HIV develop broadly neutralizing antibodies (bNAbs) capable of preventing cell-infection by diverse HIV isolates, which are the type of antibodies researchers wish to elicit by vaccination.

"We've found that the people who develop broadly-reactive neutralizing antibodies which are about 30% of those infected tend to have a healthier immune system that differs from others who don't develop those antibodies," Stamatatos explained, saying that these antibodies target only a few regions of HIV which is good from the standpoint of vaccine development. "It gives us less to target," he said.

In addition, the new findings show that these antibodies are generated much sooner than previously thought, in some cases as soon as a year after infection.

"These studies provide a strong rationale to begin teasing out the early immunological signals that allow some individuals, but not others, to mount broadly reactive neutralizing antibody responses," adds co-author Galit Alter, Ph.D.

"Now we know that these broadly-reactive neutralizing antibodies don't develop simply by chance and we can work to unders
'/>"/>

Contact: Dr. Leo Stamatatos
leo.stamatatos@seattlebiomed.org
Public Library of Science
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers learn why PSA levels reflect prostate cancer progression
2. Adrenaline receptor frozen in action by VIB researchers
3. Researchers show how 1 gene becomes 2 (with different functions)
4. Technique allows researchers to identify key maize genes for increased yield
5. University of Houston researchers helping Pentagon build mind-controlled prosthetics
6. Researchers show environmental changes may affect vital cooperate bird behaviors
7. Washington State University researchers honored by top science society
8. 10 UC Riverside researchers recognized by the American Association for the Advancement of Science
9. AAAS honors Iowa State, Ames Lab researchers for distinguished science
10. Researchers brave icy waters to study Arctic food web
11. Carnegie Mellon researchers identify Facebook neurons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... YORK, NY (July 24, 2014) Scientists at ... Institute are one step closer to creating a ... a patient,s own cells. , For the ... (iPS) cells lines from skin samples of patients ... developed an accelerated protocol to induce these stem ...
(Date:7/24/2014)... 2014 -- Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the "Company") announced ... control Phase 3 study of Zerenex (ferric citrate), the ... treatment of hyperphosphatemia in patients with end-stage renal disease ... iRon delivery with FErric CiTrate in EsrD) was published ... Society of Nephrology ( JASN ). ...
(Date:7/24/2014)... YORK, NY (July 24, 2014) Scientists at ... Institute are one step closer to creating a ... a patient,s own cells. , For the ... (iPS) cells lines from skin samples of patients ... developed an accelerated protocol to induce these stem ...
Breaking Biology News(10 mins):NYSCF scientists one step closer to cell therapy for multiple sclerosis patients 2Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 4NYSCF scientists 1 step closer to cell therapy for multiple sclerosis patients 2
... Institutes of Health announced today that it will fund ... -- chemical modifications to genes that result from diet, ... to specific human diseases and biological processes. ... as part of the NIH Roadmap for Medical Research,s ...
... University is being honored for one of its programs ... institute,s intern program has received the roundtable group,s Most ... award, as the best pollution prevention project/program. The honor ... The award is presented based on a program,s ...
... LA JOLLA, Calif., September 15, 2009 -- Researchers ... have discovered that reactive oxygen species, such as ... in forming invadopodia, cellular protrusions implicated in cancer ... professor and director of the Tumor Microenvironment Program ...
Cached Biology News:NIH funds grantees focusing on epigenomics of human health and disease 2NIH funds grantees focusing on epigenomics of human health and disease 3NIH funds grantees focusing on epigenomics of human health and disease 4K-State Pollution Prevention Institute's intern program named best 2Reactive oxygen's role in metastasis 2
(Date:7/25/2014)... Muncie, IN (PRWEB) July 25, 2014 ... Administration (FAA) has granted a 60-day extension for the ... of the Special Rule for Model Aircraft established by ... Act of 2012. The 60-day extension establishes the new ... the United States Department of Transportation/FAA notice published in ...
(Date:7/24/2014)... July 24, 2014 Gain recognition ... Supply Chain of the biotech industry. Nominations are ... Awards, brought to you by the Bio ... of supply chain management professionals for the past ... stakeholders of the Biotech industry – Manufacturers, Service ...
(Date:7/24/2014)... forces worldwide rely on sophisticated equipment, trained personnel, ... public areas against terrorist attacks. A revolutionary new ... to make their job much easier. , The ... of Tel Aviv University ,s School of Chemistry ... by the Herzliya company Tracense, picks up the ...
(Date:7/24/2014)... natural and synthetic processes prefer to settle into ... energyit is within the realm of non-equilibrium conditions ... changes in energy and phases, such as temperature ... allow humans to regulate their body temperature, airplanes ... seismic activity. , But even though these ...
Breaking Biology Technology:FAA Grants Comment Extension at the Request of AMA 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3Nano-sized chip 'sniffs out' explosives far better than trained dogs 2New approach to form non-equilibrium structures 2
... 2 According to the National Institute of Health, 40 percent ... stage of diabetic retinopathy. Diabetic retinopathy, damage to the retina ... in people with diabetes and is one of the most feared ... patients who,ve had diabetes for 10 years or more will experience ...
... , ... that a new market research report is available in ... Trends , http://www.reportlinker.com/p0164494/Chromium---Global-Market-Trends.html , Worldwide ... while growth in aerospace and industrial gas turbine markets ...
... PLYMOUTH, Mass., Dec. 1 Harvest Technologies Corp. ( ... 60-patient clinical trial conducted at Sri Ramachandra Medical Center ... treat patients with non-reconstructable Critical Limb Ischemia (CLI). Sri ... based in Chennai, India and one of the largest ...
Cached Biology Technology:Study Shows Pine Bark Improves Microcirculation, Retinal Swelling And Visual Acuity In Early Diabetic Retinopathy 2Study Shows Pine Bark Improves Microcirculation, Retinal Swelling And Visual Acuity In Early Diabetic Retinopathy 3Study Shows Pine Bark Improves Microcirculation, Retinal Swelling And Visual Acuity In Early Diabetic Retinopathy 4Reportlinker Adds Chromium - Global Market Trends 2Reportlinker Adds Chromium - Global Market Trends 3Reportlinker Adds Chromium - Global Market Trends 4Reportlinker Adds Chromium - Global Market Trends 5Reportlinker Adds Chromium - Global Market Trends 6Reportlinker Adds Chromium - Global Market Trends 7Reportlinker Adds Chromium - Global Market Trends 8Reportlinker Adds Chromium - Global Market Trends 9Harvest Technologies Announces Trial Results in its India Study Using BMAC to Treat Patients With Non-Reconstructable Critical Limb Ischemia 2Harvest Technologies Announces Trial Results in its India Study Using BMAC to Treat Patients With Non-Reconstructable Critical Limb Ischemia 3
Mouse monoclonal [3576] to Yellow Fever Virus ( Abpromise for all tested applications). Antigen: Tissue / cell preparation...
... 2 Detection System combines the indirect ... principle and Signets unique formulation of ... and reliablility. Signet reagents will achieve ... and automated protocols. ,Signets USA ...
6X Loading Buffer is intended for gel electrophoresis of DNA fragments or PCR products....
Ideally suited for resolving DNA and RNA 10-1000 bases especially PCR products ranging from 100-1000 bp. Gelling temp. (4%) 27C Melting temperature 65C. EEO: 0.10 Rnase/Dnase: none detected...
Biology Products: