Navigation Links
Researchers report on the early development of anti-HIV neutralizing antibodies
Date:1/14/2011

New findings are bringing scientists closer to an effective HIV vaccine. Researchers from Seattle Biomedical Research Institute (Seattle BioMed), Vanderbilt University and the Ragon Institute of MGH, MIT and Harvard report findings showing new evidence about broadly-reactive neutralizing antibodies, which block HIV infection. Details are published January 13 in the open-access journal PLoS Pathogens.

According to author Leo Stamatatos, Ph.D., director of the Viral Vaccines Program at Seattle BioMed and a major stumbling block in the development of an effective vaccine against HIV is the inability to elicit, by immunization, broadly reactive neutralizing antibodies (NAbs). These antibodies bind to the surface of HIV and prevent it from attaching itself to a cell and infecting it. However, a fraction of people infected with HIV develop broadly neutralizing antibodies (bNAbs) capable of preventing cell-infection by diverse HIV isolates, which are the type of antibodies researchers wish to elicit by vaccination.

"We've found that the people who develop broadly-reactive neutralizing antibodies which are about 30% of those infected tend to have a healthier immune system that differs from others who don't develop those antibodies," Stamatatos explained, saying that these antibodies target only a few regions of HIV which is good from the standpoint of vaccine development. "It gives us less to target," he said.

In addition, the new findings show that these antibodies are generated much sooner than previously thought, in some cases as soon as a year after infection.

"These studies provide a strong rationale to begin teasing out the early immunological signals that allow some individuals, but not others, to mount broadly reactive neutralizing antibody responses," adds co-author Galit Alter, Ph.D.

"Now we know that these broadly-reactive neutralizing antibodies don't develop simply by chance and we can work to understand what makes this 30% of the HIV-infected population different," Stamatatos explained. By understanding that, we can hopefully use that information to design new immunogens and immunization protocols that can mimic the early events that lead to the development of such antibodies during natural infection."


'/>"/>

Contact: Dr. Leo Stamatatos
leo.stamatatos@seattlebiomed.org
Public Library of Science
Source:Eurekalert

Related biology news :

1. Researchers learn why PSA levels reflect prostate cancer progression
2. Adrenaline receptor frozen in action by VIB researchers
3. Researchers show how 1 gene becomes 2 (with different functions)
4. Technique allows researchers to identify key maize genes for increased yield
5. University of Houston researchers helping Pentagon build mind-controlled prosthetics
6. Researchers show environmental changes may affect vital cooperate bird behaviors
7. Washington State University researchers honored by top science society
8. 10 UC Riverside researchers recognized by the American Association for the Advancement of Science
9. AAAS honors Iowa State, Ames Lab researchers for distinguished science
10. Researchers brave icy waters to study Arctic food web
11. Carnegie Mellon researchers identify Facebook neurons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... Feb. 2, 2016  BioMEMS devices deployed ... focused on medical screening and diagnostic applications, ... Wearable devices that facilitate and assure continuous ... movement are being bolstered through new opportunities ... signal acquisition coupled with wireless connectivity and ...
(Date:2/2/2016)... Feb. 2, 2016 Checkpoint Inhibitors for ... Market Are you interested in the future ... for checkpoint inhibitors. Visiongain,s report gives those predictions ... and national level. Avoid falling behind in ... opportunities and revenues those emerging cancer therapies can ...
(Date:2/2/2016)... 2016   Parabon NanoLabs (Parabon) announced ... Research Office and the Defense Forensics and Biometrics ... the company,s Snapshot Kinship Inference software ... generally, defense-related DNA forensics.  Although Snapshot is best ... and ancestry from DNA evidence), it also has ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... Falls Church, VA (PRWEB) , ... ... ... a first-year cybersecurity conference presented by Bloomsburg University’s Digital Forensics Club, takes ... Bloomsburg, PA. The two-day event features 20+ speakers and activities such as ...
(Date:2/4/2016)... , Feb. 4, 2016  CytoSorbents Corporation ... leader commercializing its flagship CytoSorb® blood filter to ... patients around the world, announced that CEO Dr. ... at the Source Capital Group,s 2016 Disruptive Growth ... on the company.  Conference Presentation ...
(Date:2/4/2016)... , February 4, 2016 --> ... biotechnology acceleration company is pleased to provide the following update ... --> Over the last 3 months we have significantly ... purchase agreements exceeding $1,000,000. As a result, we have positioned ... Research Inc. license agreement and expect that development to continue ...
(Date:2/4/2016)... , Feb. 4, 2016  Spherix Incorporated (Nasdaq: ... the fostering and monetization of intellectual property, today provided ... Uniden in the Northern District of Texas ... forward.  Inter Partes Re-examination ("IPR") ... Patent Office.  The IPR was initiated on only certain ...
Breaking Biology Technology: