Navigation Links
Researchers report gene associated with language, speech and reading disorders
Date:8/27/2009

LAWRENCE, KAN. A new candidate gene for Specific Language Impairment has been identified by a research team directed by Mabel Rice at the University of Kansas, in collaboration with Shelley Smith, University of Nebraska Medical Center, and Javier Gayn of Neocodex, Seville, Spain. The finding, reported in the current issue of the Journal of Neurodevelopmental Disorders, was discovered by examining genes previously identified as candidate genes for reading impairments or speech sound disorders. The results point toward the likelihood of multiple genes contributing to language impairment, some of which also contribute to reading or speech impairment.

A gene on Chromosome 6 KIAA0319 was associated with variability in language abilities in a study of children with Specific Language Impairment (SLI) and their family members, as well as with variability in speech and reading abilities. Children with SLI who were selected for the study had no hearing loss, general intellectual deficit or autism.

Language ability involves vocabulary and grammar, whereas speech involves the accuracy of sound production. Both language and speech ability contribute to a child's ability to read. The finding that a candidate gene could influence all three abilities suggests a common pathway that could contribute to overlapping strengths or deficiencies across speech, language and reading.

According to Rice, "We don't understand the biological mechanisms yet but it's important that we have identified the first gene that could be involved across these three different dimensions of development."

Previous research has established that Chromosome 6 is among those that are linked to Speech Sounds Disorder (SSD) and Reading Disability/Dyslexia (RD). Rice said the findings are consistent with numerous reports documenting that language impairments and reading disability often co-exist.

The study involved 322 individuals, including children with SLI, their parents, siblings, and other family members. "We have come to realize that language really sets the platform for reading to emerge and to thrive," Rice added. "Without a solid language system, it's much harder to get reading going."

The study is part of a 20-year research program conducted by Rice, who is the Fred and Virginia Merrill Distinguished Professor of Advanced Studies and director of the Center for Biobehavioral Neurosciences in Communication Disorders at KU's Life Span Institute. Co-investigators on the genetics project were Shelley Smith, professor of pediatrics in the Department of Pediatrics and the Munroe Meyer Institute for Genetics and Rehabilitation at the University of Nebraska Medical Center, and Javier Gayn, Head of the Analysis Group at Neocodex, in Seville, Spain. Neocodex is a research company that specializes in genomics analysis.


'/>"/>

Contact: Karen Henry
kahenry@ku.edu
785-864-0756
University of Kansas
Source:Eurekalert

Related biology news :

1. Bats use love songs during mating, researchers say
2. Idaho researchers win grant to explore DNA frontier
3. UCSF researchers identify 2 key pathways in adaptive response
4. Disrupting a destructive duo: U of T Mississauga researchers inhibit cancer proteins
5. Researchers boost production of biofuel that could replace gasoline
6. Researchers find genetic link between physical pain and social rejection
7. UTSA biology researchers demystify elusive war zone bacterium
8. UGA researchers propose model for disorders caused by improper transmission of chromosomes
9. Researchers develop new, more-sensitive assay for detecting DNA methylation in colon cancer
10. NIH-funded researchers sequence exomes of 12 people
11. USC researchers identify regulatory genetic sequences that may predict risk for prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2020)... ... 09, 2020 , ... Today CJ BIO announced the first in a series ... “fifth taste” phenomenon that is revolutionizing ingredient mixes, nutritional content and flavor profiles across ... Monday, July 13, 2020 at11:00 AM (CDT) during SHIFT20, the virtual edition of the ...
(Date:7/1/2020)... ... 01, 2020 , ... Cure Glioblastoma, a registered 501(c)(3) nonprofit ... aggressive adult brain cancer—announced today the appointments of its first Senior Fellows: John ... the organization’s initiatives and overall vision. , "Senior Fellows are more than advisors; ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... healthcare, and Renovagen Ltd, a UK supplier and manufacturer of innovative portable renewable ... testing operations in the fight against the COVID-19 pandemic in Zambia. , One ...
Breaking Biology News(10 mins):
(Date:6/28/2020)... ... June 25, 2020 , ... Lumeda Inc. ... cancer, today announced the company has entered a license agreement with Roswell Park ... Lumeda globally exclusive rights to Roswell Park intellectual property surrounding a novel medical ...
(Date:6/23/2020)... ... June 23, 2020 , ... DeCurtis ... environments, announced today that Derek Fournier has been appointed CEO and President. Founder ... Board, effective immediately. , “DeCurtis Corporation has been on an incredible journey ...
(Date:6/23/2020)... ... 2020 , ... Nobilis Therapeutics, a biopharmaceutical company focused on ... Investigational New Drug application (IND) with the U.S. Food & Drug Administration (FDA) ... in patients with panic disorder (PD). , "Adding a PD trial to a ...
(Date:6/11/2020)... ... June 09, 2020 , ... PathSensors Inc., a Baltimore biotechnology ... Research (SBIR) program funded by the National Institute of Food and Agriculture (NIFA) ... The project’s goal was to engineer and develop a field-deployable instrument for portable ...
Breaking Biology Technology: