Navigation Links
Researchers report advances vs. preeclampsia, including potential prediction
Date:10/14/2010

PROVIDENCE, R.I. [Brown University] In as many as 8 percent of pregnancies worldwide, women who seem fine for months develop preeclampsia, a serious complication causing symptoms including high blood pressure, severe swelling, and problems with placental development. The untreatable and unpredictable condition, with no known cause, often requires premature delivery, and can sometimes kill the mother and the fetus.

In a new study, researchers led by a team at Brown University and Women & Infants Hospital describe two major advances: a well-defined animal model of preeclampsia and a potential lab test for diagnosing the disease in people.

"Our model is the first pregnancy-specific animal model," said Surendra Sharma, professor of pediatrics at the Warren Alpert Medical School of Brown University and a research scientist at Women & Infants, "and our predictive assay is the first one where we can go back to the first trimester and predict problems."

Sharma is a senior author on the study, published online this month in The American Journal of Pathology. In addition to pediatrics researchers, the study also involved scientists at the Lifespan Center for International Health Research, Harvard Medical School in Boston, and Linkoping University and Helsingborg Hospital in Sweden.

Model mice

Building on research linking the presence of the immune system secretion Interleukin-10 (IL-10) to a successful course of pregnancy, the researchers started experimenting with mice genetically engineered to lack IL-10. They hypothesized that if they isolated blood serum from human patients with preeclampsia and gave a dose of it to the mice, the rodents would develop preeclampsia symptoms. That is exactly what happened.

Just to be sure, the researchers gave the preeclampsia serum to mice that were not pregnant. Nothing happened, confirming that the onset of preeclampsia symptoms in the engineered mice was a conse
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers develop oral delivery system to treat inflammatory bowel diseases
2. In Parkinsons disease, brain cells abandon mitochondria, researchers report
3. MIT researchers develop a better way to see molecules at work in living brain cells
4. Scripps researchers, UCSD chemists to create center devoted to chemistrys influence on climate
5. New fisheries system will save about $20 million, Iowa State University researchers find
6. The world is full of darkness, reflected in the physiology of the human retina, Penn researchers say
7. FSU researchers examine how bacteria become resistant to antibiotics
8. Knome Awards Human Exome Sequencing and Analysis to Biomedical Researchers
9. Researchers study sleep apnea and lack of oxygen
10. Bonn researchers use light to make the heart stumble
11. Researchers engineer adult stem cells that do not age
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/6/2014)... 2014 - Insilico Medicine, Inc, a Baltimore-based bioinformatics ... related diseases announced a research collaboration with the ... Oncology, Inc (OTC: CSBR). , "There are many ... but Champions Oncology,s TumorGraft technology is unique in ... regimen experimentally generating vast amounts of valuable data. ...
(Date:11/5/2014)... de Janeiro, Brazil -Individuals show great diversity in their ... males and females greatly differ in their perceptual evaluation ... of smell tests. , Sex differences in ... behaviors and may be connected to one,s perception of ... emotions. Thus, women,s olfactory superiority has been suggested to ...
(Date:11/4/2014)... Medicine announced today that it is a Grand ... Bill & Melinda Gates Foundation. Laura Goetzl, ... Sciences; and Vice Chair of Research and Academic ... pursue an innovative global health and development research ... Neurodevelopment.", Grand Challenges Explorations (GCE) funds individuals worldwide ...
Breaking Biology News(10 mins):Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2The female nose always knows: Do women have more olfactory neurons? 2Temple University School of Medicine receives Grand Challenges Explorations grant 2
... that can break down plant biomass into the precursors of ... to produce alternatives to petroleum. But the potential of this ... cannot break down lignin, a highly stable polymer that makes ... Streptomyces bacteria are among few microorganisms known to ...
... 14, 2013As scientists continue to unravel the complexity of the ... role in both normal physiology and disease, one particular class ... attention. Guest Editor Tom Cech, PhD and Executive Editor Fintan ... advancing research area in their Editorial " The (Noncoding) ...
... Studies at Le Bonheur Children,s Hospital in Memphis, ... RSV, replicate in humans, mutate to avoid the immune ... DeVincenzo, MD, medical director of Molecular Diagnostics and Virology ... Microbiology, Immunology, and Molecular Biology at The University of ...
Cached Biology News:A microbial biorefinery provides new insight into how bacteria regulate genes 2A microbial biorefinery provides new insight into how bacteria regulate genes 3Noncoding RNAs offer huge therapeutic and diagnostic potential 2Leading RSV researcher publishes work at Le Bonheur Children's 2Leading RSV researcher publishes work at Le Bonheur Children's 3
(Date:11/22/2014)...   , ... zu KLOX    Mariano ... Officer bestellt    KLOX ist bestens ... zugelassenen Behandlungssystems zur Wundheilung zu beginnen    , ... sehr erfreut, die folgenden personellen Veränderungen anzukündigen: ...
(Date:11/21/2014)... , Nov. 21, 2014   TRU-D SmartUVC LLC ... their superbug-killing UVC automated disinfection robot, TRU-D SmartUVC, at FIS ... from Nov. 23 to 26 at Stand 23. ... United Kingdom,s largest infection-related event of ... societies to one of the leading events of its type ...
(Date:11/21/2014)... Offering a complete line of laboratory ... promotion . The Sartorius Entris Balance is the perfect ... and easy-to-maintain balance entry level balance. , The Entris ... to help customer’s bridge the gap between a basic ... very durable. Sartorius is the second biggest balance manufacturer ...
(Date:11/21/2014)... Palo Alto, Calif. (PRWEB) November 20, 2014 ... (CHI), a nonprofit, public policy research organization representing ... and pharmaceutical firms, and PwC US ... other states in life sciences industry growth. The ... and 2013. The 2015 California Biomedical Industry ...
Breaking Biology Technology:KLOX Technologies meldet Neubesetzung von Führungspositionen 2KLOX Technologies meldet Neubesetzung von Führungspositionen 3KLOX Technologies meldet Neubesetzung von Führungspositionen 4KLOX Technologies meldet Neubesetzung von Führungspositionen 5TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 3Pipette.com Announces an Extension on the Sartorius Entris Balance Promotion to the End of 2014 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4
... 220 V, is used for agitation and mixing ... staining and destaining of gels and blots, and ... (8-40 rpm) and can handle a maximum load ... two 29 x 21 cm platforms covered with ...
...
...
... Wyatt Technology's family of light scattering instruments. ... temperature chromatograph and enables you to get ... The HTmD is easily installed in the ... Alliance 2000 device and enables you to ...
Biology Products: