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Researchers recreate SARS virus, open door for potential defenses against future strains
Date:11/25/2008

than two dozen countries in North America, South America, Europe and Asia before the global outbreak was contained. Of the more than 8,000 people worldwide who were diagnosed with SARS in 2003, 774 died.

Baric said SARS is believed to have originated in bats, and "jumped" to humans either directly or through raccoon dogs and palm civets, both considered delicacies for humans in China.

"Although the strains associated with the 2002-2003 epidemic no longer circulate in humans, the animal precursor strains are common and will likely re-emerge in the future," he said. "The key problem is that many of the vaccines and therapeutics targeting the 2002-2003 epidemic strains may not work against future emergent strains."

Baric said synthesizing the SARS co-variant that infects bats and then modifying it so that it can grow well in laboratory animals will allow researchers to search for vaccines and treatments that would be effective against any strain of SARS that might infect humans in the future. Viruses that start in animals and mutate to infect humans tend to be slightly different each year. An example is the influenza virus, which is different each year and requires a different vaccine each year to provide immunity.

"By reconstructing the synthetic bat SARS virus, we have a model that will allow us to design better vaccines and drugs that will treat any strain of this virus that infects humans," Baric said.

The value of the research goes beyond SARS, he added.

"Potentially, we can apply this technology to many other emerging viruses," he said. "Then, perhaps we wouldn't have to develop a new therapy each year, but can find treatments that will be effective against all of the root viruses."


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Contact: Patric Lane
patric_lane@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
Source:Eurekalert

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