Navigation Links
Researchers put the bite on mosquitoes
Date:1/16/2008

Few things sting like a mosquito's bite--especially if that bite carries a disease such as malaria, yellow fever, Dengue fever or West Nile virus. But if researchers from The University of Arizona in Tucson have their way, one day mosquito bites may prove deadly to the mosquitoes as well.

"Our goal is to turn the female mosquito's blood meal into the last meal she ever eats," said project leader Roger L. Miesfeld, a professor of biochemistry and molecular biophysics in UA's College of Science and a member of BIO5 and the Arizona Cancer Center.

Other UA researchers involved with the project include Patricia Y. Scaraffia, Guanhong Tan, Jun Isoe, BIO5 member Vicki H. Wysocki, and the late Michael A. Wells.

These researchers have discovered that one particular mosquito species, Aedes aegypti, has a surprisingly complex metabolic pathway, one that requires its members to excrete toxic nitrogen after gorging on human blood. If the mosquitoes fail to do so, they'll also fail to lay eggs--and will likely sicken and die.

Scaraffia, a research assistant professor in UA's department of biochemistry and molecular biophysics, and the other members of the team published their findings in the January 15 issue of the Proceedings of the National Academy of Sciences. The research was funded by the National Institutes of Health.

Miesfeld and his colleagues are seeking a molecule that is harmless to humans, but will gum up the works of mosquito metabolism, forcing the mosquitoes to hang onto the nitrogen. Such a molecule would kill both the mosquitoes and their would-be progeny--thus slowing the spread of disease.

Once found, this molecule--and similar molecules aimed at other mosquito species--could be developed into an insecticide and sprayed in places where mosquitoes congregate, such as around water and on mosquito netting.

The researchers also envision developing an oral insecticide--a mosquito-slaying pill that members of a community with a high instance of, say, yellow fever or malaria might take to reduce the mosquito population. The pill wouldn't be a vaccine; if people who took it were later bitten by a disease-carrying mosquito, they would still become infected. However, the mosquito would ingest the insecticide along with the blood, causing her to bear fewer young and possibly die before she could bite anyone else.

"The whole community would essentially become one big mosquito trap," Miesfeld said. Over time, mosquito populations and disease rates would both decline. "It would be a group effort that in the long run could have a huge impact."

In a world where both mosquitoes and the diseases they carry are becoming increasingly resistant to known insecticides and medicines, finding new ways to fight them is crucial.

"This would be one more weapon in our arsenal against diseases that kill millions of people a year," Miesfeld said.


'/>"/>

Contact: Deborah Daun
ddaun@email.arizona.edu
520-626-2059
University of Arizona
Source:Eurekalert  

Related biology news :

1. Researchers find association between food insecurity and developmental risk in children
2. Iowa State researchers look for smaller, cheaper, 1-dose vaccines
3. Japanese and German researchers meet to discuss climate change
4. Type 1 diabetes triggered by lazy regulatory T-cells: McGill researchers
5. Researchers uncover new piece to the puzzle of human height
6. Researchers create mathematical model of fruit fly eyes
7. Snoozing worms help Penn researchers explain the evolution of sleep
8. Researchers move 2 steps closer to understanding genetic underpinnings of autism
9. Rices West honored as one of Texas best researchers
10. Stanford researchers publish review of US medical device regulation
11. University of Alberta researchers report breakthrough in lowering bad cholesterol, fatty acid levels
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers put the bite on mosquitoes
(Date:6/7/2016)...  Syngrafii Inc. and San Antonio Credit Union ... integrating Syngrafii,s patented LongPen™ eSignature "Wet" solution into ... result in greater convenience for SACU members and ... existing document workflow and compliance requirements. ... Highlights: ...
(Date:6/2/2016)... The Department of Transport Management (DOTM) ... million US Dollar project, for the , Supply ... Enrolment, and IT Infrastructure , to ... implementation of Identity Management Solutions. Numerous renowned international vendors participated ... was selected for the most compliant and innovative ...
(Date:6/2/2016)... LONDON , June 2, 2016 ... Systems, Manned Platforms, Unmanned Systems, Physical Infrastructure, Support & ... intelligence provider visiongain offers comprehensive analysis of ... that this market will generate revenues of $17.98 billion ... Systems acquired DVTEL Inc, a leader in software and ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Md. , June 23, 2016 A person ... from the crime scene to track the criminal down. ... the U.S. Food and Drug Administration (FDA) uses DNA evidence ... Sound far-fetched? It,s not. The FDA ... sequencing to support investigations of foodborne illnesses. Put as simply ...
(Date:6/23/2016)... --  EpiBiome , a precision microbiome engineering company, today ... from Silicon Valley Bank (SVB). The financing will allow ... drug development efforts, as well as purchase additional lab ... been an incredible strategic partner to us – one ... provide," said Dr. Aeron Tynes Hammack , EpiBiome,s ...
(Date:6/23/2016)... 2016  Blueprint Bio, a company dedicated to identifying, ... community, has closed its Series A funding round, according ... "We have received a commitment from Forentis Fund ... to meet our current goals," stated Matthew Nunez ... to complete validation on the current projects in our ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... of intelligent tools designed, tuned and optimized exclusively for Okuma CNC machining centers ... The result of a collaboration among several companies with expertise in toolholding, cutting ...
Breaking Biology Technology: