Navigation Links
Researchers pursuing arthritis protein
Date:1/9/2014

Chronic inflammation poses something of a mystery for researchers. If we become infected, the body immediately takes steps to repair and tidy it up. This process manifests itself as inflammation, which stems from a high level of activity in the immune cells, the body's defence against bacteria and viruses. But it does not always go according to plan. Every so often, the body's immune system over-reacts, and the inflammation develops into a chronic condition, resulting in diseases such as arthritis, inflammatory bowel disease and psoriasis. However, researchers are now a step closer to understanding what happens when the immune system over-reacts and causes chronic inflammation.

"Through analysing blood cells, we have observed that a particular protein called TL1A can get healthy cells to behave like those we see in chronic inflammation. This is bringing us closer to unlocking the mystery of inflammation," says Kirsten Reichwald, PhD student at the Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen. The results have been published in PLOS ONE.

Biological treatment fights arthritis

Today, doctors can use so-called biological medicines for treating arthritis, which has radically changed the outlook for patients. Biological treatment works by impeding the harmful substances that are partly responsible for advancing the chronic inflammation in the body. Almost 40 per cent of arthritis patients experience a positive effect when taking biological medicines.

"Existing biological treatment means that doctors today can halt the diseases instead of just relieving the symptoms," explains Kirsten Reichwald.

However, in order to block the right substances, doctors need detailed information about the processes that cause chronic inflammation. The researchers therefore studied cells from 50 blood donors from the blood bank at Rigshospitalet in Copenhagen, and concluded that the protein TL1A has a key role in the development of the inflammation.

"Our latest findings tell us, that the TL1A protein takes part in driving the inflammation, and therefore it makes sense to try and block the protein with biological medicines," says Kirsten Reichwald, who hopes that her future research will help to provide even more specific knowledge about inflammation.

What the researchers did

The researchers studied blood cells from blood donors in a proinflammatory environment with and without the TL1A protein. Analysed how the cells had developed, how they grew, and whether they resembled those that the researchers see in chronic inflammation. The healthy blood cells stem from the blood bank at Rigshospitalet in Copenhagen, and more than 50 donors have been examined with the same result.


'/>"/>

Contact: Kirsten Reichwald
kire@sund.ku.dk
45-61-68-65-76
University of Copenhagen
Source:Eurekalert

Related biology news :

1. Researchers discover a tumor suppressor gene in a very aggressive lung cancer
2. Researchers unveil rich world of fish biofluorescence
3. Researchers propose alternative way to allocate science funding
4. New organization brings together top researchers to sequence the genomes of invertebrates
5. Plan to delist gray wolf endangers other threatened species, researchers find
6. Researchers say fructose does not impact emerging indicator for cardiovascular disease
7. Researchers complete a milestone in defining the genetic basis of rheumatoid arthritis
8. Researchers create largest evolutionary timetree of land plants to investigate traits that permit survival in cold climates
9. Penn researchers grow liquid crystal flowers that can be used as lenses
10. UT Southwestern neuroscience researchers identify gene involved in response to cocaine
11. ASU researchers develop new device to help image key proteins at room temperature
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2016)... Nov. 22, 2016   MedNet Solutions , an ... spectrum of clinical research, is pleased to announce that ... Healthcare and Life Sciences Awards as "Most Outstanding ... an unprecedented year of recognition and growth for MedNet, ... 15 years. iMedNet ™ , ...
(Date:11/16/2016)... Nov. 16, 2016 Sensory Inc ., ... security for consumer electronics, and VeriTran , ... retail industry, today announced a global partnership that ... to authenticate users of mobile banking and mobile ... software which requires no specialized biometric scanners, ...
(Date:6/27/2016)... Research and Markets has announced the addition ... to their offering. The report ... to grow at a CAGR of 12.28% during the period 2016-2020. ... in-depth market analysis with inputs from industry experts. The report covers ... The report also includes a discussion of the key vendors operating ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... PUNE, India , December 8, 2016 ... is a comprehensive analysis, titled Global Amyloglucosidase Industry 2016 Market ... definition, classification, application, and industry chain overview are all covered ... project SWOT analysis, and investment return analysis of the Amyloglucosidase ... , , ...
(Date:12/8/2016)... USA, and CARDIFF, UK (PRWEB) , ... December ... ... with very high precision light to control cells — optogenetics — is key ... the current state of the art, spatially patterned light projected via free-space optics ...
(Date:12/8/2016)...  Anaconda BioMed S.L., a pre-clinical stage medical device ... neuro-thrombectomy system for the treatment of Acute Ischemic Stroke ... to join its Scientific Advisory Board (SAB). The SAB ... scientific and clinical experts to Anaconda BioMed S.L., as ... ® to its clinical phase. The SAB is ...
(Date:12/8/2016)... ... December 08, 2016 , ... This CAST literature review and report looks ... authors focus on the economic effects in countries that are major global commodity exporters ... and the resultant risk of low level presence (LLP) puts large volumes of trade ...
Breaking Biology Technology: