Navigation Links
Researchers publish study on neuronal RNA targeting
Date:9/7/2011

SUNY Downstate scientist Ilham Muslimov, MD, PhD, along with senior author Henri Tiedge, PhD, professor of physiology and pharmacology and of neurology, published a study suggesting that cellular dysregulation associated with certain neurodegenerative disorders may result from molecular competition in neuronal RNA transport pathways.

The paper appeared in the Journal of Cell Biology, titled, "Spatial Code Recognition in Neuronal RNA Targeting: Role of RNA-hnRNP A2 Interactions." The article was highlighted in an accompanying editorial, "RNA Targeting Gets Competitive."

Dr. Tiedge notes, "In contrast to DNA, in which information coding is one-dimensional (i.e. linear), RNA can encode information in three-dimensional architectural motifs. Dr. Muslimov has now identified RNA motifs that act as spatial codes in nerve cells, directing RNA to dendrites and synapses." A synapse is a junction that allows a neuron (nerve cell) to pass an electrical or chemical signal to another cell, and dendrites are the branched processes of neurons that act to conduct electrochemical stimulation to the neuronal cell body.

He adds, "Just like number 7 on a New York subway train is a code for the destination 'Times Square,' Dr. Muslimov's RNA motifs are codes for the dendrite and synapse destinations. They make sure RNAs are delivered to cellular sites where they are supposed to operate."

"Sometimes, an RNA may express an inappropriately high number of targeting motifs, with the result that the resources of the transport system become overwhelmed. It is as if too many passengers are trying to enter trains at the same time, exceeding system capacity. We have congestion, and transport is disrupted."

Dr. Tiedge explains that Dr. Muslimov's work indicates that in nerve cells, excessive competition for common transport resources may result in compromised dendritic delivery of RNA. "In the example Dr. Muslimov studied, the culprit is an RNA that contains the genetic information for the fragile X mental retardation protein. Once the number of motifs structures in this RNA exceeds a threshold (usually around 55), the RNA becomes excessively competitive and begins to commandeer, at the expense of other RNAs, common resources of the cellular transport system."

"Dr. Muslimov's data raise the possibility that the resulting neurodegenerative disease, the fragile X-associated tremor/ataxia syndrome, is precipitated by a neuronal transport problem," Dr. Tiedge concludes.


'/>"/>

Contact: Ron Najman
ron.najman@downstate.edu
718-270-2696
SUNY Downstate Medical Center
Source:Eurekalert

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2016)...   MedNet Solutions , an innovative SaaS-based eClinical ... research, is pleased to announce the attainment of record-setting ... result of the company,s laser focus on (and growing ... it,s comprehensive, easy-to-use and highly affordable cloud-based technology platform. ... MedNet growth achievements in 2015 include: , ...
(Date:1/13/2016)... January 13, 2016 ... addition of the  "India Biometrics Authentication ... Forecast (2015-2020)"  report to their ... has announced the addition of the  ... - Estimation & Forecast (2015-2020)" ...
(Date:1/7/2016)... , Jan. 7, 2016 This BCC Research ... for biometric technologies and devices, identifying newer markets and ... various types of biometric devices. Includes forecast from 2015 ... Identify newer markets and explore the expansion of the ... Examine each type of biometric technology, determine its current ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... 4, 2016 Beike Biotechnology, the ... attended a ceremony in late 2015 to mark their ... in 2016. --> --> ... for Personalized Cell Therapy" was hosted by the Shenzhen ... both subsidiaries of Beike Biotechnology Co., Ltd. ...
(Date:2/4/2016)... YORK , February 4, 2016 ... QBIO), a biotechnology acceleration company is pleased to provide the ... --> Over the last 3 months we ... and securities purchase agreements exceeding $1,000,000. As a result, we ... our Mannin Research Inc. license agreement and expect that development ...
(Date:2/4/2016)... Sinovac Biotech Ltd. ("Sinovac" or the "Company") ... products in China , today announced ... received on February 4, 2016 a preliminary non-binding proposal ... of PKU V-Ming ( Shanghai ) Investment ... Development ( Shenzhen ) Fund Management Co., ...
(Date:2/4/2016)... ... February 04, 2016 , ... Many of the engineers at ... years. What sets them apart from other cuvette manufacturers is their supercharged customer ... website. On top of this steady flow of inside information, they have recently ...
Breaking Biology Technology: