Navigation Links
Researchers publish study on neuronal RNA targeting
Date:9/7/2011

SUNY Downstate scientist Ilham Muslimov, MD, PhD, along with senior author Henri Tiedge, PhD, professor of physiology and pharmacology and of neurology, published a study suggesting that cellular dysregulation associated with certain neurodegenerative disorders may result from molecular competition in neuronal RNA transport pathways.

The paper appeared in the Journal of Cell Biology, titled, "Spatial Code Recognition in Neuronal RNA Targeting: Role of RNA-hnRNP A2 Interactions." The article was highlighted in an accompanying editorial, "RNA Targeting Gets Competitive."

Dr. Tiedge notes, "In contrast to DNA, in which information coding is one-dimensional (i.e. linear), RNA can encode information in three-dimensional architectural motifs. Dr. Muslimov has now identified RNA motifs that act as spatial codes in nerve cells, directing RNA to dendrites and synapses." A synapse is a junction that allows a neuron (nerve cell) to pass an electrical or chemical signal to another cell, and dendrites are the branched processes of neurons that act to conduct electrochemical stimulation to the neuronal cell body.

He adds, "Just like number 7 on a New York subway train is a code for the destination 'Times Square,' Dr. Muslimov's RNA motifs are codes for the dendrite and synapse destinations. They make sure RNAs are delivered to cellular sites where they are supposed to operate."

"Sometimes, an RNA may express an inappropriately high number of targeting motifs, with the result that the resources of the transport system become overwhelmed. It is as if too many passengers are trying to enter trains at the same time, exceeding system capacity. We have congestion, and transport is disrupted."

Dr. Tiedge explains that Dr. Muslimov's work indicates that in nerve cells, excessive competition for common transport resources may result in compromised dendritic delivery of RNA. "In the example Dr. Muslimov studied, the culprit is
'/>"/>

Contact: Ron Najman
ron.najman@downstate.edu
718-270-2696
SUNY Downstate Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... delivered by Caesarean section have a different intestinal flora than ... why this is the case and what it means for ... Medical Sciences therefore decided to scrutinise the impact of birth ... of newborn mouse pups. , The study ... lower number of cells that strengthen the immune system, says ...
(Date:7/9/2014)... hunts in Indiana state parks have helped restore the ... by overabundant populations of white-tailed deer, a Purdue study ... associate professor of forest ecology, found that a 17-year-long ... in state parks has successfully spurred the regrowth of ... browsing deer. , Jenkins said that while hunting ...
(Date:7/9/2014)... (July 9, 2014) Emerging fungal pathogens pose ... parasitic group, causing population declines of amphibians, bats, ... University of South Florida published in the prestigious ... acquire behavioral or immunological resistance to a deadly ... , "Acquired resistance is important because it ...
Breaking Biology News(10 mins):Mouse study: Natural birth may strengthen the immune system 2Hunting gives deer-damaged forests in state parks a shot at recovery 2USF study: Amphibians can acquire resistance to deadly fungus 2
... an important discovery in the interdisciplinary study of split-brain research. ... left and right hemispheres. Split-brain research has been conducted ... processing is largely located in the left side of the ... an area processed by the right side of the ...
... between partners is a fundamental requisite in agricultural biotech ... from a four year study into what built or ... In a special supplement published in the UK-based journal ... from the Sandra Rotman Centre at the University Health ...
... been considered a major risk factor for cardiovascular disease. ... but the mechanisms of how arteries stave off hardening ... Perelman School of Medicine, University of Pennsylvania, Wistar Institute, ... the protein apolipoprotein E (apoE) plays a major role ...
Cached Biology News:UCSB scientists report 'new beginning' in split-brain research, using new analytical tools 2UCSB scientists report 'new beginning' in split-brain research, using new analytical tools 3UCSB scientists report 'new beginning' in split-brain research, using new analytical tools 4Study details essential role of trust in agricultural biotech partnerships 2Study details essential role of trust in agricultural biotech partnerships 3Study details essential role of trust in agricultural biotech partnerships 4Study details essential role of trust in agricultural biotech partnerships 5Study details essential role of trust in agricultural biotech partnerships 6Softening arteries, protecting the heart 2Softening arteries, protecting the heart 3
(Date:1/15/2014)... Freeslate, Inc ., the leading ... Lupin Limited, one of India’s top five pharmaceutical companies, ... System for high throughput solid form screening. ... a wide range of quality, affordable generic and branded ...
(Date:1/14/2014)... San Diego, CA (PRWEB) January 14, 2014 ... based on the products of cells grown under simulated ... an international license agreement with Suneva Medical, Inc. for ... media (CCM). , This agreement is an ...
(Date:1/14/2014)... DIEGO and BETHESDA, Md. ... are joining together with two institutes from the National ... reliable tools for bringing safer, more effective treatments to ... the National Center for Advancing Translational Sciences (NCATS) and ...
(Date:1/14/2014)... , Jan. 14, 2014   Kinaxis ®, provider of ... and sales and operations planning ( S&OP ) service, is ... Summit , which will be held at the Hilton San ... join Kinaxis customer Elisabeth Kaszas , Director of Supply ...
Breaking Biology Technology:Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... as the "holy grail" of nanoscience, researchers at the ... the first time used DNA to guide the creation ... dimensions measured in billionths of a meter). The ability ... functional materials that take advantage of the unique properties ...
... 30 Monogram,Biosciences, Inc., (Nasdaq: MGRM ) announced ... 7, 2008 at 4:30 p.m. (Eastern Time) to discuss,fourth ... for 2008.,The call will be hosted by Mr. William ... in the live teleconference, please call (877) 545-1409,or (719) ...
... (TSX: HBP / Frankfurt: WKN 918864), AURORA, ... that at the Company,s Annual General Meeting held ... resolutions presented by,management, appointing KPMG LLP as auditor, ... Slawomir Majewski, and Gordon Lickrish as,directors, and approving ...
Cached Biology Technology:DNA technique yields 3-D crystalline organization of nanoparticles 2DNA technique yields 3-D crystalline organization of nanoparticles 3Monogram Biosciences Announces Fourth Quarter 2007 Financial Results Conference Call 2Helix BioPharma shareholders vote in favour of management 2