Navigation Links
Researchers prolong the half-life of biopharmaceutical proteins
Date:9/18/2009

ted in "PASylated" form. In first trials with animals, TUM scientists established that PASyated interferon has a half-life in the blood that is prolonged by a factor of 60, which should allow a significant extension of dosing intervals during medicinal therapy.

A further advantage is the simplified biotechnological production: The DNA segments carrying the information for the PAS amino acid sequence and for the interferon can simply be attached to each other and then, for instance, used for transforming bacteria. The bacteria then produce the PASylated interferon in one piece, thus making much fewer production steps necessary in comparison with the chemical coupling of PEG. According to Skerra, "this will lead to a significant drop in production cost."

In principle all small proteins currently used as medication or in development in pharmaceutical companies for example, growth factors or functional antibody fragments can be PASylated. Thus there could be a huge market for the new technology. Consequently, Prof. Skerra and his team initiated the founding of a new biotech company, XL-Protein GmbH (http://www.xl-protein.com), which started its operations last spring. "Our technology has the potential to give birth to a whole new generation of blockbuster medications," the TUM biochemist is convinced. Several of the new drugs are already at an advanced stage of preclinical development.


'/>"/>

Contact: Patrick Regan
presse@zv.tum.de
49-892-892-2743
Technische Universitaet Muenchen
Source:Eurekalert

Page: 1 2

Related biology news :

1. WCMC-Q researchers unlock genetic secrets of date palm
2. Weeding out marijuana: Researchers close in on engineering recognizable, drug-free Cannabis plant
3. Dartmouth researchers get personal with genetics
4. Ecosystem researchers to hold science briefing for policymakers
5. UAB researchers looking for genetic predictors for suicide
6. Rice researchers seek better vaccine procedure
7. Researchers find first evidence of virus in malignant prostate cells
8. Diabetes advance: Researchers find gene that causes resistance to insulin
9. Researchers find 2 more genetic risk factors for Alzheimers disease
10. Researchers restore missing protein in rare genetic brain disorder
11. Mayo Clinic researchers find that protein believed to protect against cancer has a Mr. Hyde side
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... from Ume University, Sweden, have explored two different ... reaction sequence leading to the formation of oxygen ... published in the scientific journal Nature Communications ... present day synthetic catalysts for water oxidation, which ... for the direct storage of solar energy in ...
(Date:7/11/2014)... normal circumstances, astrocytes participate in normal physiological ... exhibit therapeutic and repairing effects on brain ... found that nerve cells differentiated from adipose-derived ... viability, which produces influences on subsequent studies ... Hospital, Hebei United University, China demonstrated that ...
(Date:7/10/2014)... In Santa Fe, Albuquerque, and other major cities in ... watered with treated municipal wastewater rather than precious potable ... more than 40% of all golf courses receive treated ... courses. , Additionally, golf courses and homeowners alike ... nutrient in fertilizer is nitrate. A New Mexico State ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2'Tailored' water -- the latest in lawn care 2
... normal immune cells to become specialized tumor fighters, demonstrating for ... the body and shrink large tumors in humans. , ... the experimental treatment saw their tumors shrink and were declared ... after the therapy began, Steven A. Rosenberg of the National ...
... bacterial perpetrator of the often severe disease caused ... keep looking: Scientists at the National Institute of ... National Institutes of Health, have exonerated a toxin ... Panton-Valentine leukocidin (PVL) is one of many toxins ...
... dot on his computer screen. The dot ?which represents ... into a mass with finger-like projections that looks like ... biology envisions a future when computer simulations like this ... and formulate individualized treatment plans. For the last two ...
Cached Biology News:Science researchers genetically transform immune cells into tumor fighters 2Science researchers genetically transform immune cells into tumor fighters 3MRSA toxin acquitted: Study clears suspected key to severe bacterial illness 2MRSA toxin acquitted: Study clears suspected key to severe bacterial illness 3Math model predicts cancer behavior 2Math model predicts cancer behavior 3Math model predicts cancer behavior 4
(Date:7/10/2014)... Capital, a firm specializing in acquiring and managing food ... the Slim-Fast brand from Unilever. Unilever will retain a ... were not disclosed. Slim-Fast is a branded ... shakes, powders, bars and snacks to retail customers throughout ... United Kingdom and Ireland.  The ...
(Date:7/10/2014)... in the fight against terrorism with the creation of ... with the use of light and special glass fibres. ... B: Chemical , the researchers describe a novel optical ... low as 6.3 ppm (parts per million). It requires ... "Traditionally explosives detection has involved looking for metals that ...
(Date:7/10/2014)... RICHLAND, Wash. The lithium-ion batteries that power our ... run longer on a single charge with the help ... the porous material to replace the graphite traditionally used ... more than 10 times the energy storage capacity of ... lithium-ion battery electrode was published today in Nature ...
(Date:1/15/2014)... approach akin to assembling a club sandwich at ... (NIST) researchers have succeeded in crafting a uniform, ... of foam commonly used in upholstered furniture and ... nanotube-coated polyurethane foam was reduced 35 percent compared ...
Breaking Biology Technology:Kainos Capital Acquires Slim-Fast From Unilever 2Detecting trace amounts of explosives with light 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3Layered security: Carbon nanotubes promise improved flame-resistant coating 2
... April 15 Hovione is pleased to announce,that ... that it intends,to use Hovione,s TwinCaps(R) dry powder ... an inhaled long-acting neuraminidase inhibitor active,against the influenza ... III clinical trials in Japan and other Asian ...
... MADISON, N.J., April 15 Quest Diagnostics,Incorporated (NYSE: ... resolution of the,previously disclosed federal government investigation related ... kit manufacturing subsidiary closed,voluntarily in 2006. Quest Diagnostics ... 2004. , Quest Diagnostics ...
... Development for Neurological ConditionsBROOMFIELD, Colo., April 15 ... in central nervous system (CNS) diseases, announced today ... development company. The new company will focus ... molecule drugs for acute and chronic neurological conditions ...
Cached Biology Technology:Hovione's TwinCaps(R) Inhaler in Phase III Clinical Trials for Influenza 2Hovione's TwinCaps(R) Inhaler in Phase III Clinical Trials for Influenza 3Quest Diagnostics Finalizes Previously Announced Settlement With Government Related to Test Kit Subsidiary Closed in 2006 2Accera, Inc. Launches Neuera Pharmaceuticals, Inc. 2Accera, Inc. Launches Neuera Pharmaceuticals, Inc. 3
lid holder -see Blotters (Semi-Dry) for more info...
... QPlate is the consumable ... 16 contains 16 individually controlled ... contains a sophisticated liquid flow ... fast and precise solution and ...
This kit is designed to select cells labeled with phycoerythrin- (PE-) conjugated antibodies. Kit includes reagents for labeling 3 x 10 9 cells and EasySep magnet....
... bring you ease of use and rapid solutions to meet your laboratory's requirements for data management ... ... ... CLARA® is the standard software for Staccato Systems and ...
Biology Products: