Navigation Links
Researchers prolong the half-life of biopharmaceutical proteins
Date:9/18/2009

ted in "PASylated" form. In first trials with animals, TUM scientists established that PASyated interferon has a half-life in the blood that is prolonged by a factor of 60, which should allow a significant extension of dosing intervals during medicinal therapy.

A further advantage is the simplified biotechnological production: The DNA segments carrying the information for the PAS amino acid sequence and for the interferon can simply be attached to each other and then, for instance, used for transforming bacteria. The bacteria then produce the PASylated interferon in one piece, thus making much fewer production steps necessary in comparison with the chemical coupling of PEG. According to Skerra, "this will lead to a significant drop in production cost."

In principle all small proteins currently used as medication or in development in pharmaceutical companies for example, growth factors or functional antibody fragments can be PASylated. Thus there could be a huge market for the new technology. Consequently, Prof. Skerra and his team initiated the founding of a new biotech company, XL-Protein GmbH (http://www.xl-protein.com), which started its operations last spring. "Our technology has the potential to give birth to a whole new generation of blockbuster medications," the TUM biochemist is convinced. Several of the new drugs are already at an advanced stage of preclinical development.


'/>"/>

Contact: Patrick Regan
presse@zv.tum.de
49-892-892-2743
Technische Universitaet Muenchen
Source:Eurekalert

Page: 1 2

Related biology news :

1. WCMC-Q researchers unlock genetic secrets of date palm
2. Weeding out marijuana: Researchers close in on engineering recognizable, drug-free Cannabis plant
3. Dartmouth researchers get personal with genetics
4. Ecosystem researchers to hold science briefing for policymakers
5. UAB researchers looking for genetic predictors for suicide
6. Rice researchers seek better vaccine procedure
7. Researchers find first evidence of virus in malignant prostate cells
8. Diabetes advance: Researchers find gene that causes resistance to insulin
9. Researchers find 2 more genetic risk factors for Alzheimers disease
10. Researchers restore missing protein in rare genetic brain disorder
11. Mayo Clinic researchers find that protein believed to protect against cancer has a Mr. Hyde side
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... findings of a new study suggest two ways to effectively ... as well in obese women, compared to women of a ... one-size-fits-all method, researchers say, but as the population has increased ... works for obese women. Studies have consistently found that obesity ... which may in turn affect how well the pill prevents ...
(Date:7/28/2014)... hunter, but the target of his work consists of ... special methods and instruments. Benjamin Hause, an assistant research ... Kansas State University, recently published an article about one ... important find in the United States. , "We had ... it was," Hause said. "We used next-generation sequencing to ...
(Date:7/28/2014)... University researchers are using magnetic beads and DNA "springs" ... used as microscale models for polymer macromolecules. , The ... theory in the 1950s, can be made as stiff ... interest to materials scientists who study the basic physics ... and biomolecular engineer Sibani Lisa Biswal and graduate student ...
Breaking Biology News(10 mins):Strategies identified to improve oral contraceptive success with obese women 2Researcher using next-generation sequencing to rapidly identify pathogens 2Researcher using next-generation sequencing to rapidly identify pathogens 3Seeing is bead-lieving 2
... painful relationship with Campylobacter jejuni, we are just starting ... the leading cause of bacterial food-borne illness in the ... of diarrhea worldwide. The Centers for Disease Control estimate ... , While most sufferers recover after a few unpleasant ...
... University in Ithaca and Weill Cornell Medical College in ... protein biomarkers in cerebrospinal fluid that acts as a ... patients living with Alzheimer's disease. , The research will ... Annals of Neurology. , Right now, physicians ...
... 2006 -- A new study in Journal of the World ... smaller shrimp of the same gender when competing for food, ... adult males of the species are typically much smaller than ... and gender are important factors in acquiring food," says study ...
Cached Biology News:The biggest bug in gut discomfort 2Protein 'fingerprint' in spinal fluid could spot Alzheimer's disease 2Protein 'fingerprint' in spinal fluid could spot Alzheimer's disease 3
(Date:7/29/2014)... Sunnyvale, CA (PRWEB) July 29, 2014 ... for medical devices, and cloud based eClinical technologies, have ... Med Device Online. These follow a long line of ... high profile publications including Life Science Leader, Pharmaceutical Online, ... Basics Clinovo provided a paper by CTO Marc Desgrousilliers, ...
(Date:7/28/2014)... building materials using light, developed by researchers at the ... are often considered the realm of science fiction, such ... cloaked starships won,t be a reality for quite some ... materials with building blocks a few billionths of a ... that light flies through them, and works on large ...
(Date:7/28/2014)... Texas (PRWEB) July 28, 2014 ... and China Lubricant Industry” is a professional ... Global Lubricant market. The report introduces Lubricant ... and industry chain structure and industry overview. ... including China’s domestic market as well as ...
(Date:7/28/2014)... , July 28, 2014 Research and ... "Global Synthetic Biology Market 2014-2018" report to their ... The term synthetic biology covers the designing and ... as well as the redesigning of natural biological systems ... to be a form of extreme genetic engineering because ...
Breaking Biology Technology:Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 2Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 3Building 'invisible' materials with light 2Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 2Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 3Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 4Global Synthetic Biology Market 2014-2018 2
... BETHESDA, Md., Sept. 3 Spherix Inc. (Nasdaq: ... therapy, and a provider of technical and regulatory consulting services ... Dr. Claire Kruger, Chief Executive Officer, and Dr. Robert Lodder, ... & Renshaw 11(th) Annual Healthcare Conference at 1:10 PM ET ...
... , FREMONT, Calif., Sept. 3 WaferGen Biosystems, ... gene expression, genotyping, cell biology and stem cell research systems, ... Officer, will deliver a corporate presentation at the Rodman & ... September 9-11, 2009, at the New York Palace Hotel in ...
... , , ... (Nasdaq: MASI ), the inventor of Pulse ... announced that its Radical-7 and Rad-57 Pulse CO-Oximeters have ... Army. AWR certification is a fundamental milestone that allows ...
Cached Biology Technology:Spherix Incorporated to Present at the Rodman & Renshaw 11th Annual Healthcare Conference 2WaferGen to Present at the Rodman and Renshaw Annual Global Investment Conference 2WaferGen to Present at the Rodman and Renshaw Annual Global Investment Conference 3Masimo Radical-7(R) and Rad-57(R) Pulse CO-Oximeters(TM) Awarded Airworthiness Release Certification by the United States Army 2Masimo Radical-7(R) and Rad-57(R) Pulse CO-Oximeters(TM) Awarded Airworthiness Release Certification by the United States Army 3Masimo Radical-7(R) and Rad-57(R) Pulse CO-Oximeters(TM) Awarded Airworthiness Release Certification by the United States Army 4
... Analysis of large numbers of samples may ... which requires minimum operator attention. System control ... and interface CE 4900. The elegant, powerful ... Windows XP and Windows 98 and 2000., The ...
...
capacity 250 mL...
... This CLS number is a ... easily match Cornings product number. ... please order under the old ... customer service for assistance. ID ...
Biology Products: