Navigation Links
Researchers pinpoint possible new cause for unexplained miscarriages
Date:11/1/2011

TORONTO, ON., Nov. 1, 2011Researchers at St. Michael's Hospital have identified a potential new cause for unexplained miscarriages in mice.

They also identified two possible treatments to prevent these miscarriages and their work has broader implications for the development of new drugs to treat heart attacks and strokes.

The researchers, led by Dr. Heyu Ni, found that the same kind of blood-clotting in coronary arteries or blood vessels in the brain that causes heart attacks and strokes also happens in the placenta. The massive clotting can destroy the placenta, block blood flow to the fetus and cause miscarriages.

This condition is known as fetal and neonatal immune thrombocytopenia (FNIT), a bleeding disorder in which mothers generate antibodies that attack and destroy platelets in their fetuses and newborns. Platelets are the small cells in the blood that play a key role in clotting. In severe cases, FNIT may lead to bleeding in the brains of the fetuses and newborns and cause neurological impairment or even death.

The condition affects between one in 800 and one in 1,500 live births and is more commonly reported among Caucasians.

Maternal antibodies to one specific platelet antigen, HPA-1 (human platelet antigen) cause 75-95 per cent of FNIT cases. Antigens are the proteins that antibodies attack because they think they are a foreign substance such as bacteria or a virus.

Dr. Ni and his team discovered a novel mechanism that might partially explain this problem. They found that another antigen, HPA-2, causes a type of FNIT never described before that can lead to miscarriages in more than 83 per cent of mice. There have been only six to eight reported live births in the world of humans with FNIT caused by HPA-2. The new research suggests the reason these cases appear to be so rare is that most of the affected fetuses died through miscarriages, before doctors examined them.

Dr. Conglei Li and
'/>"/>

Contact: Leslie Shepherd
shepherdl@smh.ca
416-864-6094
St. Michael's Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. Savannas, forests in a battle of the biomes, Princeton researchers find
2. Lung regeneration closer to reality with new discovery by Weill Cornell Medical College researchers
3. Researchers build largest protein interaction map to date
4. WSU researchers demonstrate rare animal model for studying depression
5. UC Davis researchers discover complexities of DNA repair
6. Researchers generate first complete 3-D structures of bacterial chromosome
7. Researchers at NYU Langone Medical Center review the microbiome and its possible role in cancers
8. Researchers discover that same gene has opposite effects in prostate, breast cancers
9. Researchers do precise gene therapy without a needle
10. Researchers explore planktons shifting role in deep sea carbon storage
11. Stanford researchers examine impact of green politics on recent national elections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... business incubator, received a $1.4 million federal grant to ... staunch bleeding during brain surgery. , Surgeons can spray ... bio-polymer solutions in the gel will cohere and control ... The gel can shorten an intracranial surgery by 30- ... the patient,s skull to be open and less anesthesia, ...
(Date:7/10/2014)... State University have developed a small, portable and ... over the world better understand the radiation around them, ... poses a health risk. , The device was developed ... incident in Fukushima, Japan, in 2011, when many regional ... being exposed to and whether their homes, food, environment ...
(Date:7/10/2014)... Cancer Research Centre (CNIO) Macromolecular Crystallography Group has ... called BuD to DNA in order to redirect ... researcher who led the study, says the discovery: ... instructions contained in the genome to treat genetic ... is published in the journal Acta Crystallographica, ...
Breaking Biology News(10 mins):A start-up at NJIT develops bleeding-control gel for brain surgery 2Sophisticated radiation detector designed for broad public use 2Sophisticated radiation detector designed for broad public use 3CNIO scientists develop technology to redirect proteins towards specific areas of the genome 2
... Singapore unravel the inner workings of cells, invent a ... broadband communications for multimedia gaming and IPTV, and explore ... some of the winning works of this years National ... three National Science Awards (NSA), two National Technology Awards ...
... received an offer to establish its first foreign institute in ... proposed the sum of $86.9 million for the next 10 ... State of Florida will contribute funds to complete the financing, ... will take place. The County,s decision paved the ...
... YORK (Sept. 10, 2007) -- It,s well known that ... health problems from cancer to heart disease. Now a ... York City looks at how they do their dirty ... arteries. The evidence points to nicotine, the addictive chemical ...
Cached Biology News:Singapore National Science and Technology Awards 2Singapore National Science and Technology Awards 3Singapore National Science and Technology Awards 4Singapore National Science and Technology Awards 5Palm Beach County wants to establish a Max Planck Institute in Florida 2Nicotine may accelerate atherosclerosis, may be as dangerous as tar 2Nicotine may accelerate atherosclerosis, may be as dangerous as tar 3
(Date:1/15/2014)... CA (PRWEB) January 15, 2014 ... research solutions, today announced that Lupin Limited, one of ... Freeslate’s CM Protégé PharmD System for high ... Mumbai, India, is focused on a wide range of ...
(Date:1/14/2014)... CA (PRWEB) January 14, 2014 Histogen, ... the products of cells grown under simulated embryonic conditions, ... license agreement with Suneva Medical, Inc. for physician-dispensed aesthetic ... , This agreement is an amendment to ...
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014  Organovo announced ... from the National Institutes of Health (NIH) to help ... effective treatments to patients on a faster timeline. Organovo ... Sciences (NCATS) and the National Eye Institute (NEI) to ...
(Date:1/14/2014)... 2014   Kinaxis ®, provider of RapidResponse ®, a ... operations planning ( S&OP ) service, is proud to be ... will be held at the Hilton San Diego Bayfront, January ... Elisabeth Kaszas , Director of Supply Chain at Amgen, ...
Breaking Biology Technology:Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... Sigma-Aldrich(TM) (Nasdaq:,SIAL), a life science company dedicated ... world,s researchers, and Oxford,BioMedica (LSE: OXB), a leading ... key order confirming the strength and validity of,intellectual ... in,the research field to Sigma-Aldrich. The ruling was ...
... antibody uses novel approach to "de-cloak" cancers -, ... Inc., (TSX:,ARI), a biotechnology company discovering and developing ... new findings have been,presented from its Trop-2 and ... Trop-2 and CD59 abstracts at the AACR press,conference ...
... Novocell, Inc., a leading stem cell,engineering company, today ... Vice President, Clinical & Regulatory Affairs of,Amylin Pharmaceuticals, ... Kolterman joined Amylin in 1992 and has served ... until present and as Senior,Vice President, Regulatory Affairs ...
Cached Biology Technology:Sigma-Aldrich and Oxford BioMedica Win Key Ruling in Open Biosystems Patent Infringement Dispute 2Sigma-Aldrich and Oxford BioMedica Win Key Ruling in Open Biosystems Patent Infringement Dispute 3Arius announces new findings in Trop-2 and CD59 CANCER antibody programs 2Arius announces new findings in Trop-2 and CD59 CANCER antibody programs 3Novocell Appoints Orville G. Kolterman, M.D. to Board of Directors 2
This buffer is Specifically formulated to be used with Endogen's Poly-HRP Streptavidin...
... Analyst Software has been optimized for the ... allow the software to quickly and accurately ... well of an ELISA plate or each ... Software has been customized to incorporate standard ...
... An easy-to-use solution that enables fully automated ... 400 Hybridization Station has been designed to ... the throughput necessary to perform a wide ... performed in the range 485C; denaturations of ...
The Piezo Power MicroDissection (PPMD) system is designed for rapid isolation of single cells or small cell areas...
Biology Products: