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Researchers piggyback to safer reprogrammed stem cells
Date:2/27/2009

on during the reprogramming process. Once the Piggybac Klf4 is removed, they report, iPS cells can go on to create normal mice when introduced into newly developing mouse embryos and can give rise to the offspring of these mice by contributing to their reproductive cells. This is the most stringent test of the normality of iPS cells. As Professor Smith explains below, this is a significant advance in the field.

"The paper we've published in Development (http://dev.biologists.org/), together with two other publications in Nature', says Professor Smith, ' is a significant technical development in the field as together these papers present a more reliable and precise method for generating iPS cells. The method allows for greater control over the genetic modification process and this is fully reversible once reprogramming is complete. Therefore, the final iPS cells carry no potentially damaging foreign DNA. Our findings published in Development (http://dev.biologists.org/) show that this approach produces perfectly reprogrammed mouse cells. The Nature papers show that it can also work in human cells. These studies provide a new tool to help advance basic research into reprogramming and pave the way to the creation of human iPS cells suitable for biomedical applications."


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Contact: Jane Alfred
j.alfred@biologists.com
44-122-342-0007
The Company of Biologists
Source:Eurekalert

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