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Researchers piggyback to safer reprogrammed stem cells
Date:2/27/2009

Austin Smith and his research team at the Centre for Stem Cell Research in Cambridge have just published in the journal Development (http://dev.biologists.org/) a new and safer way of generating pluripotent stem cells the stem cells that can give rise to every tissue of the body.

Rapid developments in stem cell research in recent years have provided a way for stem cell scientists to convert specialised cells, such as skin cells, into stem cells that can form numerous cell types of the body. Research into the creation of these 'reprogrammed' cells so-called induced pluripotent stem (iPS) cells is of vital importance because it could lead to new ways of creating human stem cells from adult tissues for the study and treatment of disease. But there is one key problem with the techniques currently used to generate such stem cells: they rely on potentially harmful viruses to deliver the reprogramming factors that change specialised cells into iPS cells.

Now Austin Smith and his team report in the journal Development (http://dev.biologists.org/) an approach that avoids the use of such viruses. They successfully persuaded partly specialised mouse cells, called Epi-stem cells, to reprogram into iPS cells using a single reprogramming factor called Klf4. Instead of relying on viruses to introduce Klf4 into the Epi-stem cells, they turned to a special type of DNA, called a transposable element, which can insert itself into an organism's DNA and carry a cargo with it, in this case Klf4. The transposable element Smith and colleagues used in their study is called Piggybac, which delivered a single copy of Klf4 into the Epi-stem cells, causing them to reprogram into iPS cells. The researchers then used an enzyme to cut the Klf4 out of Piggybac. In doing so, they discovered that the iPS cells could maintain themselves using their own Klf4 gene, which had been switched
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Contact: Jane Alfred
j.alfred@biologists.com
44-122-342-0007
The Company of Biologists
Source:Eurekalert

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