Navigation Links
Researchers perform DNA computation in living cells
Date:7/10/2013

Chemists from North Carolina State University have performed a DNA-based logic-gate operation within a human cell. The research may pave the way to more complicated computations in live cells, as well as new methods of disease detection and treatment.

Logic gates are the means by which computers "compute," as sets of them are combined in different ways to enable computers to ultimately perform tasks like addition or subtraction. In DNA computing, these gates are created by combining different strands of DNA, rather than a series of transistors. However, thus far DNA computation events have typically taken place in a test tube, rather than in living cells.

NC State chemist Alex Deiters and graduate student James Hemphill wanted to see if a DNA-based logic gate could detect the presence of specific microRNAs in human cells. The researchers utilized a DNA-based logic gate known as an "AND" gate that was engineered to respond to the presence of two specific microRNAs known as miRNA-21 and miRNA-122.

Just as computer operations utilize different inputs to create a particular output, the researchers' DNA-based Boolean logic gate was activated only when both miRNA-21 and miRNA-122 "inputs" were present in cells. If they were present, the gate generated an "output" by releasing a fluorescent molecule.

Deiters believes that use of these logic gates could lead to more accurate tests and treatments for human disease, especially cancer.

"The fluorescent molecule we used in this logic-gate design could be useful as a marker that identifies a cancer cell," he says. "Or, instead of directing the gate to release a fluorescent molecule in the presence of particular microRNAs, we could attach therapeutic agents that are released to treat the disease itself."

Their results appear in the Journal of the American Chemical Society. The research was funded in part by grants from the American Chemical Society and the American Cancer Society.


'/>"/>

Contact: Tracey Peake
tracey_peake@ncsu.edu
919-515-6142
North Carolina State University
Source:Eurekalert

Related biology news :

1. Memorial Sloan-Kettering researchers develop new method for tracking cell signaling
2. Researchers create method to rapidly identify specific strains of illness
3. Stanford researchers say peak oil concerns should ease
4. MU researchers find condition in dogs that may help further research into human disease
5. OU researchers receive OCAST awards for health research projects
6. UCLA researchers find new clue to cause of human narcolepsy
7. Researchers discover new way to block inflammation
8. Researchers call for rethinking efforts to prevent interplanetary contamination
9. Northwestern researchers examine mechanical bases for the emergence of undulatory swimmers
10. Researchers determine factors that influence spinach contamination pre-harvest
11. Researchers discover how a mutated protein outwits evolution and fuels leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. (NASDAQ: ... announces the filing of its 2016 Annual Report on Form 10-K ... Commission. ... 10-K is available in the Investor Relations section of the Company,s ... the SEC,s website at http://www.sec.gov . 2016 Year ...
(Date:4/11/2017)... April 11, 2017 Crossmatch®, a globally-recognized ... solutions, today announced that it has been awarded ... Projects Activity (IARPA) to develop next-generation Presentation Attack ... "Innovation has been a driving force within ... will allow us to innovate and develop new ...
(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" or ... independent Directors Mr. Robin D. Richards and Mr. ... the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer said," ... and benefiting from their considerable expertise as we move forward ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are ... 5.5 million people each year. Especially those living in larger cities are affected by ... in one of the most pollution-affected countries globally - decided to take action. , ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... ... Science Center’s FirstHand program has won a US2020 STEM Mentoring Award. Representatives of ... award for Excellence in Volunteer Experience from US2020. , US2020’s mission is to ...
(Date:10/10/2017)... ... October 10, 2017 , ... The ... prestigious awards honoring scientists who have made outstanding contributions to analytical ... during Pittcon 2018, the world’s leading conference and exposition for laboratory science, which ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... 5, 2017, in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which ... video EEG, in detecting generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). ...
Breaking Biology Technology: