Navigation Links
Researchers observe single protein dimers wavering between two symmetrically opposed structures
Date:6/19/2009

LA JOLLA, CA, June 19, 2009Researchers at The Scripps Research Institute, the University of California, San Diego, and Ohio State University have used a very sensitive fluorescence technique to find that a bacterial protein thought to exist in one "natural" three-dimensional structure (shape), can actually twist itself into a second form, depending on the protein's chemical environment. One folded form is active and the other is inactive, but the protein can easily morph from one state to another.

The scientists say their discovery, published in the online Early Edition of in The Proceedings of the National Academy of Sciences (PNAS) on June 8, 2009, emphasizes that such shape shifting by proteins is a common way of regulating cellular activities. This direct view provides a neat example of the dynamic and complex nature of proteins, contrasting with a single preferred folded structure that is determined by the energy balance between the amino acids that make them up.

The group of Scripps Research Associate Professor Ashok Deniz has conducted a series of studies that use novel fluorescence methods to show that both simple and complex proteins can swiftly change their structures. In March, Deniz and his Scripps Research team published a study, also in PNAS, demonstrating how a simple protein associated with development of Parkinson's disease can switch shapes back and forth between different structures, depending on its binding to molecular partners.

Now, a collaboration among the Deniz laboratory, the group of Jos N. Onuchic of the University of California, San Diego, (UCSD) and the laboratory of Thomas J. Magliery of Ohio State University, has shown that a protein dimer made up of two identical parts can actually twist itself so that one copy of the protein is turned upside down if its environment is only slightly altered.

"It has long been a puzzle as to how proteins, which can theoretically adopt an ex
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Caltech researchers explore how cells reconcile mixed messages in decisions about growth
2. UC Davis researchers visualize formation of a new synapse
3. UBC researchers develop new method to study gambling addictions
4. UCLA cancer researchers develop model that may help identify cancer stem cells
5. Researchers from around the globe coming to K-State June 21 for workshop on Fusarium fungus
6. Duke, Harvard researchers to monitor bonobo reintroduction
7. Rice University researchers ask if biofuels will lead to a drink or drive
8. Aussie and Kiwi researchers make double MS genetic discovery
9. Researchers describe implausible chemistry that produces herbicidal compound
10. Universitat Autonoma de Barcelona researchers first to clone mice in Spain
11. Protein that triggers plant cell division revealed by researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... article published online in Behavioral Brain Research ... brain as a result of chronic alcohol exposure that ... , Clinical assessments and research indicate that individuals with ... This can occur when people are actively drinking, when ... abstaining. , "Sleep-wake disturbances can last for months, ...
(Date:9/29/2014)... when the supercontinent of Pangea was starting to break up ... kinds of reptiles called phytosaurs and rauisuchids were at the ... the two top predators didn,t interact much as the former ... land. But those ideas are changing, thanks largely to the ... online in September in the German journal Naturwissenschaften ...
(Date:9/29/2014)... Growing Demand From Huge ... Security Concerns Continue to Propel Biometrics Market in ... is one of the fastest growing biometrics markets ... majorly in various government projects such as National ... biometrics dominates the country,s biometrics market, with other ...
Breaking Biology News(10 mins):Tooth buried in bone shows prehistoric predators tangled across land, sea 2India Biometrics Market to Surpass USD2.7 Billion by 2019, Finds TechSci Research Study 2India Biometrics Market to Surpass USD2.7 Billion by 2019, Finds TechSci Research Study 3
... flat. Even the flattest of basement membranes has topography; ... , Unlike the princess kept awake by the ... cultured on a substrate deliberately printed with nanoscale ... of Wisconsin–Madison. , The researchers used soft ...
... been stopped early due to preliminary results indicating that ... HIV during heterosexual intercourse by 53 percent. , The ... 12 to review the interim data. Based on the ... trial and recommended that all men enrolled in the ...
... Give or take a few dozen trillions, a human adult ... roundworm has exactly 959 cells. , Yet we have ... University, who has been exploring two “highly conserved? cell-signaling pathways ... we have a lot of common enemies, particularly soil-borne ...
Cached Biology News:Embryonic stem cells do better on bumpy nanoscale mattress 2Male circumcision reduces HIV risk, study stopped early 2Male circumcision reduces HIV risk, study stopped early 3Worms produce surprise insight into human fever 2
(Date:9/29/2014)... 29, 2014 Transparency Market Research, in ... SPPS, LPPS, HPPS, by Application - Cancer, Metabolic, CVS, ... and by Delivery) - Global Industry Analysis, Size, Share, ... the global peptide therapeutics market was worth US$14.1 billion ... by 2018 at an 8.7% CAGR. , The two ...
(Date:9/29/2014)... , Sept. 29, 2014 Burnham Securities ... Channel Group ("TCG"), a leader in healthcare venture ... formed an alliance to expand the range of ... With the alliance, Burnham Securities will be supported ... clinical medicine and management in healthcare industry to ...
(Date:9/29/2014)... 2014 Latest study ... transform network connectivity as customers put quality and ... ProLabs , the leading independent provider of global ... of their survey conducted at the 2014 European ... communications professionals from across the globe. ...
(Date:9/29/2014)... 29, 2014  Perrigo Company plc (NYSE: ... has transferred a portfolio of preclinical research assets, ... of Elan Corporation plc, to drug discovery and ... agreement, Perrigo will receive an upfront payment in ... on any future sales derived from the portfolio. ...
Breaking Biology Technology:Global Peptide Therapeutics Market to be Worth US$25.4 Billion by 2018: Transparency Market Research 2Global Peptide Therapeutics Market to be Worth US$25.4 Billion by 2018: Transparency Market Research 3Burnham Securities Inc. and The Channel Group Form Healthcare Alliance 2Burnham Securities Inc. and The Channel Group Form Healthcare Alliance 3End of an Era: OEM Dominance - Could it be a Thing of the Past? 2Perrigo Announces the Out-Licensing of Preclinical Assets to Imago Pharmaceuticals 2Perrigo Announces the Out-Licensing of Preclinical Assets to Imago Pharmaceuticals 3Perrigo Announces the Out-Licensing of Preclinical Assets to Imago Pharmaceuticals 4
... 29 Tutogen Medical, Inc.,(Amex: TTG ), a ... (allograft) and animal (xenograft) tissue, announced today,that Guy L. ... the Roth Capital Partners New York Investor Conference on,Thursday, ... conference is,being held at The Westin NY at Times ...
... N.Y., Aug. 29 Emisphere,Technologies, Inc. (Nasdaq: ... been appointed to the position of Chief Financial ... CFO and Interim Chief Executive Officer,of Astralis, Ltd., ... Michael V. Novinski, President and Chief Executive Officer. ...
... PHRM ) today announced that the U.S. ... designation for oral Azacitidine in the,treatment of Myelodysplastic ... to facilitate the development and,expedite the review of ... or,life-threatening conditions and that demonstrate the potential to ...
Cached Biology Technology:Tutogen Medical, Inc. to Present at the Roth Capital Partners 2007 New York Conference 2Emisphere Technologies, Inc. Appoints Michael R. Garone chief financial officer 2Emisphere Technologies, Inc. Appoints Michael R. Garone chief financial officer 3Pharmion's Oral Azacitidine Granted Fast Track Status for Myelodysplastic Syndromes 2Pharmion's Oral Azacitidine Granted Fast Track Status for Myelodysplastic Syndromes 3Pharmion's Oral Azacitidine Granted Fast Track Status for Myelodysplastic Syndromes 4Pharmion's Oral Azacitidine Granted Fast Track Status for Myelodysplastic Syndromes 5Pharmion's Oral Azacitidine Granted Fast Track Status for Myelodysplastic Syndromes 6
...
... The new IKATUBE ULTRA TURRAX Tube Disperser System ... homogenizing system. It offers a cleaner, safer, and ... system processes sample volumes from 2 to 15 ... type, researchers can choose one of 4 different ...
...
... Triple-angle light scattering detector for ... digital signal processing hardware for two ... UV detectors. Also contains an analog ... interfacing to strip chart recorders. Includes ...
Biology Products: