Navigation Links
Researchers note differences between people and animals on calorie restriction
Date:9/24/2008

St. Louis, Sept. 24, 2008 Calorie restriction, a diet that is low in calories and high in nutrition, may not be as effective at extending life in people as it is in rodents, according to scientists at Washington University School of Medicine in St. Louis.

Previous research had shown that laboratory animals given 30 percent to 50 percent less food can live up to 50 percent longer. Because of those findings, some people have adopted calorie restriction in the hope that they can lengthen their lives. But the new research suggests the diet may not have the desired effect unless people on calorie restriction also pay attention to their protein intake.

In an article published online this month in the journal Aging Cell, investigators point to a discrepancy between humans and animals on calorie restriction. In the majority of the animal models of longevity, extended lifespan involves pathways related to a growth factor called IGF-1 (insulin-like growth factor-1), which is produced primarily in the liver. Production is stimulated by growth hormone and can be reduced by fasting or by insensitivity to growth hormone. In calorie-restricted animals, levels of circulating IGF-1 decline between 30 percent and 40 percent.

"We looked at IGF-1 in humans doing calorie restriction," says first author Luigi Fontana, M.D., Ph.D., assistant professor of medicine at Washington University and an investigator at the Istituto Superiore di Sanit in Rome, Italy. "For years, we have been following a cohort of people from the CR Society who have been on long-term calorie restriction. We found no difference in IGF-1 levels between people on calorie restriction and those who are not."

The CR Society members, who call themselves CRONies (Calorie Restriction with Optimal Nutrition), had been on a calorie-restriction diet for an average of seven years when Fontana did the measurements, but their IGF-1 levels were virtually identical to sedentary peopl
'/>"/>

Contact: Jim Dryden
jdryden@wustl.edu
314-286-0110
Washington University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers find an essential gene for forming ears of corn
2. Researchers find animal with ability to survive climate change
3. NC State researchers get to root of parasite genome
4. UC Davis researchers discover new drug target for inflammatory disease
5. Pittsburgh researchers identify source of multipotent stem cells with broad regenerative potential
6. U of M researchers identify gene linked to common ailment in labrador retrievers
7. Friendly bacteria protect against type 1 diabetes, Yale researchers find
8. Using novel tool, UD researchers dig through cell trash and find treasure
9. More than skin deep: Theres no such thing as a safe suntan, researchers warn
10. Flatworm helps researchers study stem cells and cancer
11. Giant grass offers clues to growing corn in cooler climes, researchers report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... 2, 2015 Fingerprint Cards (FPC) ... FPC1025 from the distributor World Peace Industrial Group (WPI), ... 2015 although the major part of the shipments will ... used by smartphone manufacturers in China ... in the communicated revenue guidance of + 1 000 MSEK ...
(Date:3/30/2015)... 26, 2015 Research and Markets ( ... "Global Gesture Recognition Market in Automotive Sector 2014-2018" ... the Global Gesture Recognition market in Automotive Sector to ... 2013-2018. Gesture recognition is the ability of ... of an individual. Gesture recognition technology can be 2D-based ...
(Date:3/24/2015)... March 24, 2015   Crossmatch ™, a ... announced that its U.are.U ® 4500 Fingerprint ... Goorin Bros . to achieve PCI compliance for ... access to the POS terminal, protecting the retailer ... data breaches. With one-third of ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2
... the only ones tending their gardens. At the ... ants cultivate thriving communities of fungi and bacteria using ... are a source of food and shelter for the ... biofuel production. "We are interested in the whole ...
... Cold Spring Harbor, NY By identifying a protein that ... Laboratory (CSHL) have solved the mystery of why some infants ... and major deformities of the skin and limbs, while other ... no sign of the illness, called EEC. EEC stands ...
... 2013: Data presented at EULAR 2013, the Annual Congress ... antibody biomarkers could significantly improve diagnosis in rheumatoid arthritis ... UH-RA.14 and UH-RA.21 were investigated; as a group ... in both early and seronegative disease, with 36% ...
Cached Biology News:Researchers unearth bioenergy potential in leaf-cutter ant communities 2Researchers unearth bioenergy potential in leaf-cutter ant communities 3CSHL geneticists solve mystery of EEC Syndrome's variable severity in children 2CSHL geneticists solve mystery of EEC Syndrome's variable severity in children 3
(Date:4/16/2015)... and OSAKA, Japan , April ... Application (CiRA) of Kyoto University and Takeda Pharmaceutical ... work together to develop clinical applications of induced ... failure, diabetes mellitus, neurological disorders and cancer immunotherapy. ... (T-CiRA) is designed to expedite multiple research projects ...
(Date:4/16/2015)...  Schulman Associates IRB, Inc., the industry-leading central IRB ... lease on Laboratory Drive in the heart of ... location will house review board and service staff, which ... and customer service to clients. CBRE ... the deal, while Capital Associates Management, LLC represented the ...
(Date:4/16/2015)... April 16, 2015  In recognition of World Hemophilia Day, ... advocacy groups to illuminate more than 15 prominent landmarks red ... Boston,s Zakim Bridge and Prudential Tower, ... Mercedes-Benz Superdome and Denver,s ... evening of April 17, and coincide with hemophilia community events ...
(Date:4/16/2015)... A new infographic compiles useful information about ... to learn how Apple’s new framework can change the ... ideal since Apple made Research Kit available ... framework for developing medical research apps that Apple announced ... to collect secure clinical data and communicate via subjects’ ...
Breaking Biology Technology:CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 2CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 3Schulman IRB to Open Office in Research Triangle Park, N.C. 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 3Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 4Infographic Illustrates Potential for Research Kit to Impact Clinical Research 2Infographic Illustrates Potential for Research Kit to Impact Clinical Research 3
... Researchers at Rensselaer Polytechnic Institute have developed ... a key step for advancing integrated 3-D chip ... or anneal, at about 300 degrees Celsius. This ... ideal for use in heat-sensitive nanoelectronics, particularly for ...
... H. Robert Superko, MD, principal investigator in the landmark ... at Saint Joseph,s Hospital in Atlanta, released preliminary findings ... risk of suffering sudden death or other significant cardiac ... hundred percent increased risk for cardiac disease as compared ...
... Cardio-diagnostic company adds new apoAI measurement and apoB/apoAI ratio ... Ala., March 17 /PRNewswire/ -- ... VAP(R) Cholesterol Test in booth #1263 at ACC.09, the ... Exposition. The annual meeting takes place March 29-31, 2009, ...
Cached Biology Technology:Slimmer, stickier nanorods give boost to 3-D computer chips 2Heart Disease: An Epidemic For Firefighters 2Heart Disease: An Epidemic For Firefighters 3Atherotech to Exhibit the VAP(R) Cholesterol Test at ACC.09 in Orlando 2Atherotech to Exhibit the VAP(R) Cholesterol Test at ACC.09 in Orlando 3
Curcumin is an extract of turmeric root with antioxidant, anti-tumor promoter, and anti-inflammatory properties. Curcumin inhibits the induction of NOS in macrophages....
UGT1A6 (D-20)...
... is the smallest electronic pressure controller available ... Parker configured this unit specifically for the ... Used in carrier gas flow control, microfluidic ... and hydro-dynamic focusing, the OEM-EPC offers external ...
... Series Short Stroke Thrust Slide is designed ... mounting envelopes are limited and substantial side-loading ... internal bumpers provide millions of trouble-free cycles ... of composite bushings or recirculating ball bearings ...
Biology Products: