Navigation Links
Researchers note differences between people and animals on calorie restriction
Date:9/24/2008

St. Louis, Sept. 24, 2008 Calorie restriction, a diet that is low in calories and high in nutrition, may not be as effective at extending life in people as it is in rodents, according to scientists at Washington University School of Medicine in St. Louis.

Previous research had shown that laboratory animals given 30 percent to 50 percent less food can live up to 50 percent longer. Because of those findings, some people have adopted calorie restriction in the hope that they can lengthen their lives. But the new research suggests the diet may not have the desired effect unless people on calorie restriction also pay attention to their protein intake.

In an article published online this month in the journal Aging Cell, investigators point to a discrepancy between humans and animals on calorie restriction. In the majority of the animal models of longevity, extended lifespan involves pathways related to a growth factor called IGF-1 (insulin-like growth factor-1), which is produced primarily in the liver. Production is stimulated by growth hormone and can be reduced by fasting or by insensitivity to growth hormone. In calorie-restricted animals, levels of circulating IGF-1 decline between 30 percent and 40 percent.

"We looked at IGF-1 in humans doing calorie restriction," says first author Luigi Fontana, M.D., Ph.D., assistant professor of medicine at Washington University and an investigator at the Istituto Superiore di Sanit in Rome, Italy. "For years, we have been following a cohort of people from the CR Society who have been on long-term calorie restriction. We found no difference in IGF-1 levels between people on calorie restriction and those who are not."

The CR Society members, who call themselves CRONies (Calorie Restriction with Optimal Nutrition), had been on a calorie-restriction diet for an average of seven years when Fontana did the measurements, but their IGF-1 levels were virtually identical to sedentary peopl
'/>"/>

Contact: Jim Dryden
jdryden@wustl.edu
314-286-0110
Washington University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers find an essential gene for forming ears of corn
2. Researchers find animal with ability to survive climate change
3. NC State researchers get to root of parasite genome
4. UC Davis researchers discover new drug target for inflammatory disease
5. Pittsburgh researchers identify source of multipotent stem cells with broad regenerative potential
6. U of M researchers identify gene linked to common ailment in labrador retrievers
7. Friendly bacteria protect against type 1 diabetes, Yale researchers find
8. Using novel tool, UD researchers dig through cell trash and find treasure
9. More than skin deep: Theres no such thing as a safe suntan, researchers warn
10. Flatworm helps researchers study stem cells and cancer
11. Giant grass offers clues to growing corn in cooler climes, researchers report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... Assembly events focussed on ways to save and improve ... Canada, funded by the Government of Canada, today announced ... address this challenge. , The novel approaches include: , ... in garment factories to express, pasteurize and store breast ... to child illnesses, and lowering baby formula expense , ...
(Date:9/21/2014)... Mothers of children with autism are significantly less likely ... pregnancies than the mothers of children who are developing ... MIND Institute has found. , Low iron intake was ... the child if the mother was 35 or older ... she suffered from metabolic conditions such as obesity hypertension ...
(Date:9/21/2014)... of cowpea (black-eyed peas) is a fascinating example of ... fascinating is the story of the scientist behind the ... Legume of the 21st Century to serve as an ... book was recently published by the Crop Science Society ... Agriculture (IITA). , Singh has devoted his life,s work ...
Breaking Biology News(10 mins):Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 2Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 3Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 4Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 5Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 6Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 7Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 8Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 9Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 10Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 11Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 12Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 13Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 14Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 15Mothers of children with autism less likely to have taken iron supplements 2
... June 2008 Elsevier, a world-leading publisher of ... is pleased to announce the publication of Bioscience ... radical hypotheses on topics throughout the life sciences. ... stimulate innovation by choosing work that is interesting ...
... Highlights from the American Chemical Society journal, ACS Nano ... link to the May 2008 edition. In the current ... from solution-cast quantum dots could increase power conversion efficiencies in ... and systematic technique for evaluating the toxicity of nanomaterials in ...
... Scientists, reporting in the current issue of the online ... of epileptic seizures and behavioral abnormalities in California sea ... as a fetus. The findings follow an analysis earlier ... Marine Mammal Center that showed this brain disturbance to ...
Cached Biology News:Elsevier launches Bioscience Hypotheses 2Domoic acid from toxic algal blooms may cause seizures in California sea lions 2
(Date:9/19/2014)... NYU Langone Medical Center have found a way to ... turning adult cells into so-called pluripotent stem cells by ... new technique in mice, the researchers increased the number ... more than 20-fold compared with the standard method. They ... should generally accelerate research aimed at using stem cells ...
(Date:9/19/2014)... 2014  An entire month is dedicated to one ... Charcot-Marie-Tooth disease (CMT) – a debilitating neuromuscular disease affecting ... atrophy, weakness, and foot and hand deformities. CMT affects ... CMT is a progressive disease, and over time patients ... devices such as leg braces, wheelchairs and scooters to ...
(Date:9/19/2014)... 19, 2014 Pfenex Inc. (NYSE MKT: PFNX), ... high-value and difficult to manufacture proteins including biosimilar therapeutics, ... 21 st Annual NewsMakers in the Biotech Industry ... Bertrand Liang , chief executive officer of Pfenex, will ... business strategy on Friday, September 26, 2014 at 10:00 ...
(Date:9/19/2014)... 19, 2014 Cereal grain scientists, ... will gather October 5–8, 2014, for the AACC ... Convention Center in Providence, Rhode Island. The comprehensive ... of food scientists, chemists, microbiologists, nutritionists, and those ... production management. To date, 1,000 attendees have registered ...
Breaking Biology Technology:NYU Langone scientists report reliable and highly efficient method for making stem cells 2NYU Langone scientists report reliable and highly efficient method for making stem cells 3September is Charcot-Marie-Tooth (CMT) Awareness Month - Scheduled events, activities and important partnerships announced throughout the month! 2Pfenex to Present at Upcoming Industry Conference on September 26 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 3
... on Wednesday, March 11, 2009 at 4:30 p.m. Eastern ... Pharmaceuticals, Inc. ("OncoGenex" or the "Company") (NASDAQ: ... year 2008 financial results, reviewed the Company,s highlights and ... tremendously active year from an execution standpoint as we ...
... SAN FRANCISCO, Calif., March 10 Poniard Pharmaceuticals, Inc. ... on innovative oncology therapies, today announced that it has ... year-end 2008 financial results, which was previously scheduled to ... a.m. Eastern Time, in order to complete its financial ...
... LightSheer(R) Duet(TM) for High Speed Permanent Hair ... Rejuvenation significantly reduce treatment times to provide ... times.SANTA CLARA, Calif., March 10 Lumenis ... of laser, light-based and radio-frequency devices for ...
Cached Biology Technology:OncoGenex Reports Financial Results for Fourth Quarter and Fiscal Year 2008 and Provides Outlook for 2009 2OncoGenex Reports Financial Results for Fourth Quarter and Fiscal Year 2008 and Provides Outlook for 2009 3OncoGenex Reports Financial Results for Fourth Quarter and Fiscal Year 2008 and Provides Outlook for 2009 4OncoGenex Reports Financial Results for Fourth Quarter and Fiscal Year 2008 and Provides Outlook for 2009 5OncoGenex Reports Financial Results for Fourth Quarter and Fiscal Year 2008 and Provides Outlook for 2009 6OncoGenex Reports Financial Results for Fourth Quarter and Fiscal Year 2008 and Provides Outlook for 2009 7OncoGenex Reports Financial Results for Fourth Quarter and Fiscal Year 2008 and Provides Outlook for 2009 8OncoGenex Reports Financial Results for Fourth Quarter and Fiscal Year 2008 and Provides Outlook for 2009 9OncoGenex Reports Financial Results for Fourth Quarter and Fiscal Year 2008 and Provides Outlook for 2009 10OncoGenex Reports Financial Results for Fourth Quarter and Fiscal Year 2008 and Provides Outlook for 2009 11OncoGenex Reports Financial Results for Fourth Quarter and Fiscal Year 2008 and Provides Outlook for 2009 12Poniard Pharmaceuticals Reschedules Fourth Quarter and Fiscal 2008 Results Conference Call for Monday, March 16 2Lumenis(R) Introduces Cost-Saving Innovations at the 2009 American Academy of Dermatology (AAD) Annual Meeting 2Lumenis(R) Introduces Cost-Saving Innovations at the 2009 American Academy of Dermatology (AAD) Annual Meeting 3
... is involved in translation initiation. PHAS-II is ... bind to eIF-4E, the mRNA cap-binding protein, ... vitro and in cells. Phosphorylation in the ... This allows eIF-4E to bind to eIF-4G ...
Human GCP-2 is a member of the CXC family of chemokines. It also promotes neutrophil chemotaxis and deganulation. GF063 is an 8.0 kDa protein containing 73 amino acid residues....
... This CLS number is a ... easily match Cornings product number. ... please order under the old ... customer service for assistance. ...
MAb to IgG2 (Fc gamma-2) IgG2 (Fc, gamma-2 epitope)...
Biology Products: