Navigation Links
Researchers' new recipe cooks up better tissue 'phantoms'
Date:11/30/2011

WASHINGTON, Nov. 30The precise blending of tiny particles and multicolor dyes transforms gelatin into a realistic surrogate for human tissue. These tissue mimics, known as "phantoms," provide an accurate proving ground for new photoacoustic and ultrasonic imaging technologies. "The ability to provide phantoms that are capable of mimicking desired properties of soft tissue is critical to advance the development of new, more-accurate imaging technologies," said Stanislav Emelianov of the University of Texas at Austin and co-author of a paper appearing in the Optical Society's (OSA) open-access journal Biomedical Optics Express that describes an improved method for fabricating tissue phantoms.

Ultrasonic imaging uses high-frequency acoustic pulses to probe the structure of tissues. Another technique, photoacoustic imaging, uses low-energy laser pulses to create tiny acoustic waves that propagate through tissues. Certain tissues and materials (e.g. blood, nanoparticles used in certain tests, and fluorescent dyes), however, readily absorb the optical wavelengths typically used in photoacoustic imaging. By combining acoustic and photoacoustic imaging techniques, it's possible to create a more comprehensive picture of soft tissues. Designing effective imaging devices that can concurrently harness these two technologies, however, requires true-to-life phantoms. Emelianov and his colleagues have met this need by designing and testing a novel combination of additives that enable gelatin to acquire acoustical and optical properties that accurately match soft tissue in humans.

To match the acoustical properties, the researchers added 40-micron silica spheres to the gelatin. These particles help scatter the acoustical signal, matching the behavior of normal tissue. An emulsion of fat was also used to attenuate, or absorb, the acoustical signal. The fat additive also enhanced optical scattering of the mixture. The final ingredients were commercial dyes India ink, Direct Red 81, and Evans blue which provided similar optical absorption to natural tissues.

"These combined characteristics are of particular value because of the growing use of combined ultrasonic and photoacoustic imaging in clinical and preclinical research," says Emelianov. "Furthermore, there has been increased interest in utilizing these combined technologies in clinical applications, such as vascular imaging, lymph node assessment, and atherosclerotic plaque characterization."


'/>"/>

Contact: Angela Stark
astark@osa.org
202-416-1443
Optical Society of America
Source:Eurekalert

Related biology news :

1. BUSM researchers develop blood test to detect membranous nephropathy
2. WSU researchers use a 3-D printer to make bone-like material
3. Abstinence-only education does not lead to abstinent behavior, UGA researchers find
4. Body rebuilding: Researchers regenerate muscle in mice
5. UCLA researchers engineer blood stem cells to fight melanoma
6. BWH researchers develop a vaccine prototype stronger than traditional vaccines
7. The immune system has protective memory cells, researchers discover
8. Researchers awarded $3.2 million from NIH to pioneer advanced biomolecule discovery technology
9. 3 researchers in the Amazon clear up doubts as to the benefits of ecotourism
10. Effects of climate change to further degrade fisheries resources: UBC researchers
11. UGA researchers develop super yeast that turns pine into ethanol
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... -- higi, the health IT company that operates the largest ... , today announced a Series B investment from BlueCross ... new investment and acquisition accelerates higi,s strategy to create ... health activities through the collection and workflow integration of ... and secures data today on behalf of over 36 ...
(Date:3/24/2017)... MILAN , March 24, 2017 The Controller ... Deputy Controller Mr. Abdulla Algeen have received the prestigious international ... Continue Reading ... ... small picture) and Deputy Controller Abdulla Algeen (small picture on the right) ...
(Date:3/23/2017)... -- Research and Markets has announced the addition of ... Industry Forecast to 2025" report to their offering. ... The Global Vehicle Anti-Theft ... 8.8% over the next decade to reach approximately $14.21 billion by ... and forecasts for all the given segments on global as well ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... of a complex biological network, a depiction of a system of linkages and ... Dmitry Korkin, PhD, associate professor of computer science at Worcester Polytechnic Institute (WPI) ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... pharmaceutical and biotechnology industries to improve patient outcomes and quality of life, will ... analytical testing are being attributed to new regulatory requirements for all new drug ...
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit ... 7th and 8th June 2018 in San Francisco, CA. The Summit brings together current ... several distinguished CEOs, board directors and government officials from around the world to address ...
(Date:10/11/2017)... ... October 11, 2017 , ... A new study published in ... and fresh in vitro fertilization (IVF) transfer cycles. The multi-center matched ... , After comparing the results from the fresh and frozen transfer cohorts, the ...
Breaking Biology Technology: