Navigation Links
Researchers learn why PSA levels reflect prostate cancer progression
Date:1/13/2011

so might yield new kinds of early-detection tests for prostate cancer.

The study will be published in the Jan. 14 edition of the Journal of Biological Chemistry.

Pizzo credits lead author and signaling pathway expert, biochemist Uma Misra, Ph.D., with deducing that PSA may be involved in a signaling feedback loop that promotes more aggressive behavior in the human prostate cancer cells.

"If you were a cancer cell, you would like to turn on cell growth, turn off the process of death by cell apoptosis and you'd like to be able to migrate, and when the α2M antibody binds with the protease PSA molecule, all of that happens," Pizzo said.

Years ago, Misra discovered the GRP78 receptor on the prostate tumor cell surface, the receptor that binds the α2M antibody and the α2M-PSA complex.

"We were surprised to find that this complex binds with the protein GRP78, because we thought the GRP78 molecule only lived deep inside the cell, where it was busy taking improperly folded proteins and helping them to fold properly," Pizzo said. "It was a surprise to find GRP78 on the cell surface, with other functions. Based on the dogma of the time, we didn't think that GRP78 could function as a receptor. Even when we identified it, I doubted our findings."

Pizzo said that since Misra first made the observation about GRP78 working as a receptor, "it has turned into a cottage industry. GRP78 receptors have been discovered on many other cancer cells, including breast, ovary, liver, colon, melanoma and lung cancer cells."

"This is going to be a generic phenomenon to tumors," predicted Pizzo, who is also working to learn more about this receptor in other types of cancer cells. "Not all tumors will express GRP78 on their cell surfaces, but when they do, it probably will be a harbinger of a bad outcome."

"I think we will find that nature favors conservation and it makes sense that the body uses the
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Adrenaline receptor frozen in action by VIB researchers
2. Researchers show how 1 gene becomes 2 (with different functions)
3. Technique allows researchers to identify key maize genes for increased yield
4. University of Houston researchers helping Pentagon build mind-controlled prosthetics
5. Researchers show environmental changes may affect vital cooperate bird behaviors
6. Washington State University researchers honored by top science society
7. 10 UC Riverside researchers recognized by the American Association for the Advancement of Science
8. AAAS honors Iowa State, Ames Lab researchers for distinguished science
9. Researchers brave icy waters to study Arctic food web
10. Carnegie Mellon researchers identify Facebook neurons
11. Researchers create scoring system for PTEN mutation testing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2014)... PALM BEACH GARDENS, Fla. , Dec. 3, ... identity management solutions, today announced that its DigitalPersona ... 4500 fingerprint readers have been deployed throughout ... Carolina , South Carolina ... network headquartered in Southern Pines, North ...
(Date:11/21/2014)... Calif. , Nov. 20, 2014 Strict ... driver efficiency are piloting the North American and European ... of accidents growing, gesture recognition systems that are intuitive ... a mark in the industry. New ... Automotive Gesture Recognition Market in Europe ...
(Date:11/18/2014)... BETHESDA, Md. , Nov. 17, 2014 The ... European and U.S. regulatory agencies will speak and at least ... Quality Metrics Conference at the Omni Shoreham Hotel in ... is pleased once again to have significant support from the ... and Europe in our effort to ...
Breaking Biology News(10 mins):First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2
... newborn neurons in their brain memory hub excelled at ... declines with normal aging and in some anxiety disorders. ... antidepressant-like effects when combined with exercise, in the study ... Researchers, for the first time, pinpointed the effects ...
... demonstrates, for the first time, in vitro infection and ... hepatocytes.1 This study also verifies that HEV is ... animals to humans), which has been suggested for a ... epidemic and acute sporadic hepatitis in many developing countries. ...
... AWRE ), a leading supplier of technology and ... Edmund C. Reiter has resigned, effective April 1, 2011, as ... of the company citing personal reasons.   Richard ... been named co-CEOs and co-Presidents on an interim basis.  Mr. ...
Cached Biology News:Nurturing newborn neurons sharpens minds in mice 2Aware, Inc. Announces Resignation of Chief Executive Officer 2Aware, Inc. Announces Resignation of Chief Executive Officer 3
(Date:12/19/2014)... Diego, CA (PRWEB) December 18, 2014 ... a limited time special on Sartorius Biohit products ... Free on mLINE pipettes, Picus Electronic Pipette Trade-in Program, ... by Health and Safety officers around the world. They ... manual pipetting. Other features include:, ,     Full ...
(Date:12/19/2014)... NEW YORK , Dec. 18, 2014 ... novel therapies for the treatment of chronic pain, announced ... held today. "This was a transformational year ... a promising future for our company," said Sergio ... past year, we have executed on key financial, human ...
(Date:12/17/2014)... Achim Noack has been named global ... In this position, Noack will assist Jerry Stoller, CEO ... marketing strategy and supervise global marketing management and implementation ... tremendous knowledge and experience in the crop protection industry,” ... and innovative thinking will be a great asset for ...
(Date:12/17/2014)... IN (PRWEB) December 17, 2014 ... Laboratory Excellence following its most recent COLA inspection. ... by COLA, a national healthcare accreditation organization. Accreditation ... standards of quality in day-to-day operations, demonstrate continued ... pass a rigorous on-site laboratory survey. ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 2Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2
... Corporation , a California life-science firm, announced on Monday ... Inc. , in Madison, over a patent issue. Third ... , ,The technologies involved are some of Third Wave's ... systems. Stratagene said in a release that FullVelocity allows ...
... a biotech company, raising money is a saga that never ends. ... two things: execute on the timely achievement of key milestones you ... your next financing and where and who the money will come ... for a single round whereas most VCs usually commit for two ...
...
Cached Biology Technology:Financing of biotech companies so far in 2005: A Midwest odyssey 2Financing of biotech companies so far in 2005: A Midwest odyssey 3Financing of biotech companies so far in 2005: A Midwest odyssey 4Financing of biotech companies so far in 2005: A Midwest odyssey 5
Because it is manufactured at our ISO 9001–certified facilities in Eugene, Oregon, we can guarantee that FluoroPure grade propidium iodide is greater than or equal to 98% pure by HPLC....
MOUSE ANTI RAT RT1Bu Immunogen: Rat thymocyte membrane glycoproteins...
... cloning of BAC (100+kb), fosmid (40kb), and ... stability than any othe BAC vector. On ... yields and easy recombinant DNA purification. Available ... (pSMART VC) vectors for the highest insert ...
SHEEP ANTI HUMAN ESTRONE...
Biology Products: