Navigation Links
Researchers learn why PSA levels reflect prostate cancer progression
Date:1/13/2011

so might yield new kinds of early-detection tests for prostate cancer.

The study will be published in the Jan. 14 edition of the Journal of Biological Chemistry.

Pizzo credits lead author and signaling pathway expert, biochemist Uma Misra, Ph.D., with deducing that PSA may be involved in a signaling feedback loop that promotes more aggressive behavior in the human prostate cancer cells.

"If you were a cancer cell, you would like to turn on cell growth, turn off the process of death by cell apoptosis and you'd like to be able to migrate, and when the α2M antibody binds with the protease PSA molecule, all of that happens," Pizzo said.

Years ago, Misra discovered the GRP78 receptor on the prostate tumor cell surface, the receptor that binds the α2M antibody and the α2M-PSA complex.

"We were surprised to find that this complex binds with the protein GRP78, because we thought the GRP78 molecule only lived deep inside the cell, where it was busy taking improperly folded proteins and helping them to fold properly," Pizzo said. "It was a surprise to find GRP78 on the cell surface, with other functions. Based on the dogma of the time, we didn't think that GRP78 could function as a receptor. Even when we identified it, I doubted our findings."

Pizzo said that since Misra first made the observation about GRP78 working as a receptor, "it has turned into a cottage industry. GRP78 receptors have been discovered on many other cancer cells, including breast, ovary, liver, colon, melanoma and lung cancer cells."

"This is going to be a generic phenomenon to tumors," predicted Pizzo, who is also working to learn more about this receptor in other types of cancer cells. "Not all tumors will express GRP78 on their cell surfaces, but when they do, it probably will be a harbinger of a bad outcome."

"I think we will find that nature favors conservation and it makes sense that the body uses the
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Adrenaline receptor frozen in action by VIB researchers
2. Researchers show how 1 gene becomes 2 (with different functions)
3. Technique allows researchers to identify key maize genes for increased yield
4. University of Houston researchers helping Pentagon build mind-controlled prosthetics
5. Researchers show environmental changes may affect vital cooperate bird behaviors
6. Washington State University researchers honored by top science society
7. 10 UC Riverside researchers recognized by the American Association for the Advancement of Science
8. AAAS honors Iowa State, Ames Lab researchers for distinguished science
9. Researchers brave icy waters to study Arctic food web
10. Carnegie Mellon researchers identify Facebook neurons
11. Researchers create scoring system for PTEN mutation testing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... release is available in German . ... a very few drugs. When treating overdoses, doctors are often ... especially difficult if there is a combination of drugs involved. ... and accidentally swallows his grandmother,s pills? ETH professor Jean-Christophe Leroux ... to find an answer to this question. "The task was ...
(Date:10/16/2014)... Virginia Institute of Marine Science have received a ... to identify the streams and wetlands most vulnerable ... help local governments and citizens conserve these important ... dataset of tidal-marsh observations first gathered by VIMS ... baseline can today,s researchers accurately map the slow ...
(Date:10/16/2014)... the bowel lining develops and, in the process, suggested ... The researchers produced evidence that stem cells are responsible ... feature of the bowel lining, and believe these stem ... finding as scientists are still divided on the stem ... Wee Tan and Professor Tony Burgess from the Walter ...
Breaking Biology News(10 mins):Emergency aid for overdoses 2Emergency aid for overdoses 3EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3Cryptic clues drive new theory of bowel cancer development 2
... National Institute of Standards and Technology (NIST) and the ... evidence that engineered nanoparticles are able to accumulate within ... the team led by NIST chemist Bryant C. Nelson ... the capacity to enter plant root cells and generate ...
... senior researchers spanning seven faculties, the Renewable Energy Center ... multi-disciplinary and innovative hub in a crucial area of ... resources while advancing Israel,s economy and security. Now the ... an National Research Center for Petroleum Alternatives for Transportation ...
... (Edmonton) A medical researcher at the University of Alberta is working ... are genetic markers for autism. More than 15 scientists will examine ... see if the siblings are at high risk. , , ... intervention start before symptoms develop? , , If theres a ...
Cached Biology News:NIST/UMass study finds evidence nanoparticles may increase plant DNA damage 2Israel names Tel Aviv University's Renewable Energy Center a 'Center of Research Excellence' 2Israel names Tel Aviv University's Renewable Energy Center a 'Center of Research Excellence' 3Researchers across North America team up to find genetic markers for autism 2
(Date:10/20/2014)... Oct. 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or ... brings Q3 orders to $5.8 million and provides a good start ... North America and one in the ... new projects at record levels," said Peter Bruijns , President ... the end of Q3 than they have been for any complete ...
(Date:10/20/2014)... Oct. 20, 2014 PureTech , a ... big healthcare problems, announced today the closing of ... participation from Invesco Perpetual, a $120 Billion group ... drive PureTech,s existing pipeline forward and to advance ... the scientific creativity to really go for the ...
(Date:10/20/2014)... Tigard, OR (PRWEB) October 20, 2014 ... to participate in an investigational study of donor stem ... nationally in stem cell therapy and has performed clinical ... of this study is to determine if a single ... arthritically affected joints can help reduce pain and inflammation ...
(Date:10/19/2014)... Mass. , Oct. 19, 2014 NextCODE Health, ... the whole genome in real time, today announced the launch ... NextCODE Exchange , at the American Society of Human ... . To learn more, sign up and apply for free ... its unique features and benefits can be viewed here ...
Breaking Biology Technology:PureTech Announces Expansion with Oversubscribed $55M Funding Round 2PureTech Announces Expansion with Oversubscribed $55M Funding Round 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 5PureTech Announces Expansion with Oversubscribed $55M Funding Round 6Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3
... free Importance of Mixing webinar will compare lab mixing and large ... Reinaldo M. Machado entitled "Fundamentals of Scale-up" and "iControl Mixing Guidelines". ... ... METTLER TOLEDO invites you to view a free on-demand webinar ...
... Cytopia Limited (ASX: CYT) announced that it will present ... at the forthcoming 100th Annual Meeting of the American ... David Segal, Principal Scientist at Cytopia, will be presenting ... Molecular Therapeutics 2 poster session on Tuesday, April ...
... China, April 15 /PRNewswire-Asia-FirstCall/ -- China Sky One,Medical, Inc. ... CSKI ), a,leading fully integrated pharmaceutical company producing ... announced that it will,conduct a conference call at 10:00 ... to discuss its fourth quarter and fiscal year 2008,financial ...
Cached Biology Technology:The Importance of Mixing: How to Compare Lab Scale Mixing with Full Scale Process Vessel Performance 2Cytopia Presentation on VDA CYT997 at AACR Conference 2China Sky One Medical, Inc. Announces Conference Call to Discuss Fourth Quarter and Fiscal Year 2008 Results 2