Navigation Links
Researchers join forces to cure deadly childhood disease

ST. LOUIS -- The Center for World Health and Medicine at Saint Louis University and the Institute for OneWorld Health have established a joint research agreement to develop new drugs to combat diarrhea, which is the second leading cause of death worldwide in children under age 5.

Each year more than two million children in developing countries die from diarrheal diseases, which are caused by a wide range of bacterial, parasitic and viral pathogens. These organisms can be particularly virulent in the developing world, which is plagued by poor sanitation, unclean water, malnutrition and a lack of knowledge about how to prevent the illnesses.

Diarrhea is frequently a symptom of another disease, such as cholera and rotavirus, and turns deadly in children who rapidly lose body fluids, become severely dehydrated and go into shock.

"When children in St. Louis, Mo., develop severe diarrhea and become lethargic, their parents take them to the emergency room, where they are given IV fluids," said Peter Ruminski, executive director of the Center for World Health and Medicine.

"Places like rural Sub-Saharan Africa or Haiti lack adequate sanitation and access to clean water and don't have the same infrastructure that we have. Families there are not as readily able to hop in their vehicles, drive to the hospital and get hooked up to an IV to replenish vital body fluids. So if we can come up with a therapy to reduce fluid loss and get children through the acute attack phase of their diarrheal illness, we'll have an immediate effect on the number of children who die. Our goal is to save lives."

The collaboration between the Center for World Health and Medicine and the Institute for OneWorld Health (iOWH) aims to develop safe and effective anti-secretory drugs, which inhibit the loss of fluid in the intestine regardless of the root cause of the problem. These drugs are intended to be used as an adjunct to oral rehydration therapy.

"The Institute for OneWorld Health is committed to finding treatments for cholera and other diarrheal diseases that claim the lives of so many infants and children around the world," said Richard Chin, M.D., iOWH CEO. "This partnership will bring us closer to saving millions of children who would otherwise die from treatable diseases."

Under the agreement, the Center for World Health and Medicine will provide expertise in medicinal chemistry and pharmacology to identify potential anti-secretory drug candidates for future development.

Jon Jacobsen, Ph.D., director of chemistry at SLU's Center for World Health and Medicine, is leading the effort along with Brian Bond, Ph.D., the Center's director of pharmacology, and will closely collaborate with the medicinal chemistry group at the University of Missouri-St. Louis, led by John Walker, Ph.D.


Contact: Nancy Solomon
Saint Louis University

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
(Date:10/29/2015)... October 29, 2015 NXTD ... company focused on the growing mobile commerce market ... that StackCommerce, a leading marketplace to discover and ... Wocket® smart wallet on StackSocial for this holiday ... or the "Company"), a biometric authentication company focused ...
(Date:10/27/2015)... , October 27, 2015 ... Semantic Gaze Mapping technology (ASGM) automatically maps data from ... Tracking Glasses , so that they can be ... --> Munich, Germany , October 28-29, ... maps data from mobile eye tracking videos created with ...
(Date:10/26/2015)... ALTO, Calif. and LAS VEGAS ... Nok Nok Labs , an innovator in modern ... Alliance , today announced the launch of its latest ... first unified platform enabling organizations to use standards-based authentication ... The Nok Nok S3 Authentication Suite is ideal for ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... ... November 24, 2015 , ... Copper is an ... is bound to proteins, copper is also toxic to cells. With a $1.3 ... Institute (WPI) will conduct a systematic study of copper in the bacteria Pseudomonas ...
(Date:11/24/2015)... 2015  Clintrax Global, Inc., a worldwide provider of clinical research ... announced that the company has set a new quarterly earnings record ... quarter growth posted for Q3 of 2014 to Q3 of 2015. ... Mexico , with the establishment of an Asia-Pacific ... United Kingdom and Mexico ...
(Date:11/24/2015)... Muncie, IN (PRWEB) , ... November 24, 2015 , ... ... its newest Special Interest Group (SIG), MultiGP, also known as Multirotor Grand Prix, to ... in the last few years. Many AMA members have embraced this type of racing ...
(Date:11/24/2015)... , Nov. 24, 2015  Tikcro Technologies Ltd. (OTCQB: TIKRF) today ... December 29, 2015 at 11:00 a.m. Israel time, ... Tower, 98 Yigal Allon Street, 36 th Floor, Tel ... Eric Paneth and Izhak Tamir to the Board ... Skaliter as external directors; , approval of an amendment to certain ...
Breaking Biology Technology: