Navigation Links
Researchers improve method for finding genetic mistakes that fuel cancer
Date:6/12/2011

A dramatically better computer tool for finding the genetic missteps that fuel cancer has been developed by St. Jude Children's Research Hospital Washington University Pediatric Cancer Genome Project investigators. Researchers are using the new algorithm to help identify the chromosomal rearrangements and DNA insertions or deletions unique to cancer.

The new computational method is known as CREST, short for Clipping Reveals Structure. Using CREST, researchers identified 89 new structural differences in the cancer genomes of five St. Jude patients with a subtype of acute lymphoblastic leukemia (ALL) known as T-lineage ALL. CREST revealed complex chromosomal rearrangements, including one that involved four chromosomes. Investigators also used the tool to find 50 new variations in melanoma cells. Melanoma is the most serious form of skin cancer. The study appears in the June 12 advance online edition of the scientific journal Nature Methods.

"CREST is significantly more accurate and sensitive than existing methods of finding structural variations in next-generation sequencing data. It finds differences between a patient's normal and cancer genomes other tools cannot find," said Jinghui Zhang, Ph.D., an associate member of the St. Jude Department of Computational Biology. She is the study's senior author. "Similar tools miss up to 60 to 70 percent of these structural rearrangements in tumors. CREST ensures that scientists will be able to find important structural variations that play critical roles in tumor formation."

Zhang said the need for new ways to identify the genomic variations that lead to cancer became clear shortly after the genome project began. The St. Jude Washington University collaboration was launched in 2010 to sequence and compare the complete normal and cancer genomes of 600 young patients battling some of the most challenging forms of the disease. Organizers expect the three-year effort to revolutionize understandin
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Johns Hopkins researchers link cell division and oxygen levels
2. U-M researchers find potential new way to fight sepsis
3. Penn researchers show new evidence of genetic arms race against malaria
4. Penn researchers develop biological circuit components, new microscope technique for measuring them
5. Researchers discover potential cause of chronic painful skin
6. University of Iowa researchers identify caffeine-consuming bacterium
7. USC researchers discover genetic mutation causing excessive hair growth
8. Eating dirt can be good for the belly, researchers find
9. Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
10. UNH researchers receive grant for pioneering carbon cycle model
11. Penn researchers help nanoscale engineers choose self-assembling proteins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... Calif. , Jan. 30, 2015  It is ... great power and potential for genomic science as a ... in disease prevention and treatment.  I was honored to ... new, government-funded precision medicine program. Since ... the science of genomics—from the first sequenced genome of ...
(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ( ... - A Global Market Overview" report to their offering. ... is to ensure that an individual is who she/he is ... make use of a person,s unique physical characteristics, such as ...
(Date:1/22/2015)... /PRNewswire/ - Today, FindBiometrics, the leading source of biometrics industry news, ... website design. "When we launched FindBiometrics 12 years ... O,Neill , founder and CEO of FindBiometrics. "Now it,s maturing ... the key players on a very broad scale.  We are ...
Breaking Biology News(10 mins):J. Craig Venter, Ph.D., Co-Founder and CEO, Human Longevity, Inc. (HLI) Participates in White House Precision Medicine Event 2Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2
... in melanoma therapy. Patients whose melanoma lesions contain a ... a BRAF-specific inhibitor, PLX4032. Reports of the drug trial ... after therapy began the tumors returned and resumed growing. ... tumor learns to signal around the blocked gene by ...
... the southwestern United States are changing and will face ... declines during this century, according to a study conducted ... Service; University of California, Santa Barbara; U.S. Geological Survey; ... in the Proceedings of the National Academy of ...
... that the speed of early forest clearance following human ... much faster and more intense than previously thought. ... just a few large fires within 200 years of ... forest. Grasslands and shrubland replaced the burnt forest and ...
Cached Biology News:Killing drug-resistant melanoma requires combination therapy 2Killing drug-resistant melanoma requires combination therapy 3Drought and rising temperatures weaken southwest forests 2Early settlers rapidly transformed New Zealand forests with fire 2Early settlers rapidly transformed New Zealand forests with fire 3
(Date:2/27/2015)... Halifax, Nova Scotia (PRWEB) February 27, 2015 ... has been made aware of a fraudulent press release ... GlobeNewswire, purporting to be from Immunovaccine. This press release ... with Gilead Science, Inc. The press release did ... to the information contained within the press release. ...
(Date:2/27/2015)... Mass. , Feb. 27, 2015 ... of the NCATS rare-diseases portfolio " in ... a new financing technique to reduce the risk ... diseases and potentially unlock new levels of funding ... The product of a unique collaboration between scientists ...
(Date:2/27/2015)... 27, 2015 The fully automated ... UC) can sequentially analyze up to 48 samples ... high-sensitivity detection of targets by mass spectrometry. ... fulfill the measurement requirements of a wide range ... drug delivery and search for disease biomarkers, additives ...
(Date:2/27/2015)... FamilyFarms Group is pleased to announce its valued ... received the 2015 Tomorrow’s Top Producer Horizon Award. The ... 35, who has demonstrated excellence in the business of ... Tomorrow's Top Producer Horizon Award. Every year I look ... and learning from their experiences. It is truly humbling ...
Breaking Biology Technology:Immunovaccine Disclaims Hoax Press Release 2New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 2New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 3New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 4Shimadzu Corporation Launches Nexera UC - The World’s Foremost Unified Chromatography System 2Shimadzu Corporation Launches Nexera UC - The World’s Foremost Unified Chromatography System 3Matt Sims Receives the 2015 Tomorrow’s Top Producer Horizon Award 2
... 25, 2011 Projects In Knowledge, a fully accredited ... digital and mobile information tools for busy clinicians, has ... The company,s website ( www.projectsinknowledge.com ) won an Award ... "Most Improved Web and Intranet Site." Launched in August ...
... Mich., July 25, 2011 Robert Ettinger, the founder of ... Saturday, July 23, at home in Clinton Township, Michigan, and ... storage at very low temperatures after death in the hope ... aging and disease. Mr. Ettinger wrote ...
... -   Text-to-speech application enables researchers to listen ...  Elsevier, a world leading provider of scientific, technical ... of an audio reader application from iSpeech, provider of cloud-based ... . The iSpeech Audio Reader is the latest in a ...
Cached Biology Technology:Two Health Industry Award Wins for Projects In Knowledge® 2Two Health Industry Award Wins for Projects In Knowledge® 3Founder of Cryonics Movement Dies, is Frozen at Cryonics Institute 2iSpeech® Develops Audio Reader for Elsevier's SciVerse Applications 2iSpeech® Develops Audio Reader for Elsevier's SciVerse Applications 3iSpeech® Develops Audio Reader for Elsevier's SciVerse Applications 4
Histone H2A Polyclonal Antibody 100 ug affinity purified rabbit polyclonal antibody. Detects ~14 kDa Histone H2A. It does not cross-react with other Histones. Reacts with human/mouse/rat. Performs w...
...
CMRL Medium-1066 (1X) liquid...
MMP-20 Immunogen: Activated recombinant human MMP-2 Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: