Navigation Links
Researchers identify specific lung cancer susceptibility gene
Date:4/15/2009

CINCINNATIUniversity of Cincinnati (UC) cancer cell biologists have identified a distinct gene linked to increased lung cancer susceptibility and development. They say this geneknown as RGS17could result in a genetic predisposition to develop lung cancer for people with a strong family history of the disease.

With further investigation, they believe the gene could be used to identify high-risk patients who may benefit from earlier, more aggressive lung cancer screening.

Marshall Anderson, PhD, and his colleagues report their findings in the April 15, 2009, issue of the journal Clinical Cancer Research.

"Understanding how the RGS17 gene impacts cancer development could change clinical diagnosis and treatment as radically as discovery of the breast cancer genes (BRCA1 and BRCA2) did," explains Anderson, who has led the multi-institutional Genetic Epidemiology of Lung Cancer Consortium (GELCC) studying the genetic basis of lung cancer since 1997. "A proven genetic test could help us identify people at risk before the disease progresses."

According to the American Cancer Society, lung cancer is the leading cause of cancer related disease and death. Although tobacco smoke is the primary environmental cause of the disease, science has shown there is also a strong genetic component to the disease.

"This study represents a significant contribution to our understanding of lung cancer susceptibility and is another step toward to the goal of preventive medicine," says David Christiani, MD, MPH, a professor of occupational medicine and environmental health at the Harvard School of Public Health, whose two-page commentary on the study is published in conjunction with the GELCC team's scientific findings. "The authors undertook a daunting challenge of performing a family-based study of lung cancer in an effort to identify specific causal genes."

Genes, which are located in fixed positions on the cell's chromosomes, carry the DNA code that determines inherited characteristics, including a risk of certain diseases.

For this study, Anderson and his multi-institutional team collected biological samples from numerous multigenerational families with five or more members who were affected by lung cancer. Through a combination of what is known as "fine mapping"where genetic information is dissected and analyzedand genetic association studies, researchers identified RGS17 as a major candidate susceptibility gene for familial lung cancers.

Research has shown that lung cancer can occur sporadicallywhere people have no known risk factors or family historyor hereditarily, occurring in multiple members of the same family. In 2004, Anderson's team reported the first genetic evidence of a major lung cancer "susceptibility locus" on chromosome 6, and evidence of a susceptibility region on three other chromosomes.

The region of the original chromosome where the lung cancer markers were found contained about 100 genes, including several genes suspected to be involved in tumor suppression and cell growth.

Using a genetically altered mouse model, researchers determined that when RGS17 was suppressed, lung tumors shrank, proving the gene was involved in cancer development and must be present for cancer growth.

"What was most interesting is that this same gene was over-expressed in 60 percent of the samples from non-hereditary lung tumors," explains Anderson. "This suggests that perhaps epigenetic factors may be contributing to abnormal genetic development."

The UC-led team will conduct additional research to investigate how environmental factors may influence familial cancer development.


'/>"/>

Contact: Amanda Harper
amanda.harper@uc.edu
513-558-4657
University of Cincinnati
Source:Eurekalert

Related biology news :

1. CSHL researchers explain process by which cells hide potentially dangerous DNA segments
2. Stem cell therapy makes cloudy corneas clear, according to Pitt researchers
3. Biomedical researchers invited to design experiments for the International Space Station
4. Caltech researchers train computers to analyze fruit-fly behavior
5. International climate change researchers meet, review latest findings
6. Einstein researchers devise a fast and sensitive way to detect ricin
7. NC State researchers find soy may aid in treating canine cancers
8. Queens researchers shine light on compact fluorescent bulb problems
9. Penn researchers demonstrate a new model for drug discovery with a fluorescent anesthetic
10. Researchers discover primer to plant defense system
11. MDC researchers prevent virus induced myocarditis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2017)... York , April 19, 2017 ... as its vendor landscape is marked by the presence ... market is however held by five major players - ... Together these companies accounted for nearly 61% of the ... the leading companies in the global military biometrics market ...
(Date:4/11/2017)... 11, 2017 Crossmatch®, a globally-recognized leader ... today announced that it has been awarded a ... Activity (IARPA) to develop next-generation Presentation Attack Detection ... "Innovation has been a driving force within Crossmatch ... allow us to innovate and develop new technologies ...
(Date:4/5/2017)... , April 5, 2017  The Allen Institute ... Allen Cell Explorer: a one-of-a-kind portal and dynamic digital ... 3D imaging data, the first application of deep learning ... human stem cell lines and a growing suite of ... platform for these and future publicly available resources created ...
Breaking Biology News(10 mins):
(Date:6/23/2017)... USA, and CARDIFF, UK (PRWEB) , ... June 23, 2017 , ... ... (LANL), and Brian Lula, president of Physik Instrumente USA, have been selected as this ... and photonics . , The two have been invited along with other honorees to ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... flying hobbyists, and the University Aviation Association (UAA), the unifying voice for collegiate ... Collegiate Challenge will encourage teamwork, competition, and success through a STEM-based education platform. ...
(Date:6/22/2017)... Colorado (PRWEB) , ... June 21, 2017 , ... ... RTP regional office in North Carolina, and engages Timothy Reinhardt to manage the ... of quality leadership at Pfizer Inc, with his most recent role as the ...
(Date:6/22/2017)... ... June 22, 2017 , ... AESKU.GROUP, an innovation ... Systeme & Technologien GmbH, thereby expanding its product portfolio to include allergy and ... urticaria, asthma, atopic eczema or a food allergy. Allergies are escalating to epidemic ...
Breaking Biology Technology: