Navigation Links
Researchers identify specific lung cancer susceptibility gene
Date:4/15/2009

CINCINNATIUniversity of Cincinnati (UC) cancer cell biologists have identified a distinct gene linked to increased lung cancer susceptibility and development. They say this geneknown as RGS17could result in a genetic predisposition to develop lung cancer for people with a strong family history of the disease.

With further investigation, they believe the gene could be used to identify high-risk patients who may benefit from earlier, more aggressive lung cancer screening.

Marshall Anderson, PhD, and his colleagues report their findings in the April 15, 2009, issue of the journal Clinical Cancer Research.

"Understanding how the RGS17 gene impacts cancer development could change clinical diagnosis and treatment as radically as discovery of the breast cancer genes (BRCA1 and BRCA2) did," explains Anderson, who has led the multi-institutional Genetic Epidemiology of Lung Cancer Consortium (GELCC) studying the genetic basis of lung cancer since 1997. "A proven genetic test could help us identify people at risk before the disease progresses."

According to the American Cancer Society, lung cancer is the leading cause of cancer related disease and death. Although tobacco smoke is the primary environmental cause of the disease, science has shown there is also a strong genetic component to the disease.

"This study represents a significant contribution to our understanding of lung cancer susceptibility and is another step toward to the goal of preventive medicine," says David Christiani, MD, MPH, a professor of occupational medicine and environmental health at the Harvard School of Public Health, whose two-page commentary on the study is published in conjunction with the GELCC team's scientific findings. "The authors undertook a daunting challenge of performing a family-based study of lung cancer in an effort to identify specific causal genes."

Genes, which are located in fixed positions on the cell's chromosomes, carry the DNA code that determines inherited characteristics, including a risk of certain diseases.

For this study, Anderson and his multi-institutional team collected biological samples from numerous multigenerational families with five or more members who were affected by lung cancer. Through a combination of what is known as "fine mapping"where genetic information is dissected and analyzedand genetic association studies, researchers identified RGS17 as a major candidate susceptibility gene for familial lung cancers.

Research has shown that lung cancer can occur sporadicallywhere people have no known risk factors or family historyor hereditarily, occurring in multiple members of the same family. In 2004, Anderson's team reported the first genetic evidence of a major lung cancer "susceptibility locus" on chromosome 6, and evidence of a susceptibility region on three other chromosomes.

The region of the original chromosome where the lung cancer markers were found contained about 100 genes, including several genes suspected to be involved in tumor suppression and cell growth.

Using a genetically altered mouse model, researchers determined that when RGS17 was suppressed, lung tumors shrank, proving the gene was involved in cancer development and must be present for cancer growth.

"What was most interesting is that this same gene was over-expressed in 60 percent of the samples from non-hereditary lung tumors," explains Anderson. "This suggests that perhaps epigenetic factors may be contributing to abnormal genetic development."

The UC-led team will conduct additional research to investigate how environmental factors may influence familial cancer development.


'/>"/>

Contact: Amanda Harper
amanda.harper@uc.edu
513-558-4657
University of Cincinnati
Source:Eurekalert

Related biology news :

1. CSHL researchers explain process by which cells hide potentially dangerous DNA segments
2. Stem cell therapy makes cloudy corneas clear, according to Pitt researchers
3. Biomedical researchers invited to design experiments for the International Space Station
4. Caltech researchers train computers to analyze fruit-fly behavior
5. International climate change researchers meet, review latest findings
6. Einstein researchers devise a fast and sensitive way to detect ricin
7. NC State researchers find soy may aid in treating canine cancers
8. Queens researchers shine light on compact fluorescent bulb problems
9. Penn researchers demonstrate a new model for drug discovery with a fluorescent anesthetic
10. Researchers discover primer to plant defense system
11. MDC researchers prevent virus induced myocarditis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... , June 22, 2016  The American College of Medical ... Show Executive Magazine as one of the fastest-growing trade ... 25-27 at the Bellagio in Las Vegas ... highest percentage of growth in each of the following categories: ... companies and number of attendees. The 2015 ACMG Annual Meeting ...
(Date:6/22/2016)... 22, 2016   Acuant , the ... solutions, has partnered with RightCrowd ® ... Visitor Management, Self-Service Kiosks and Continuous Workforce ... add functional enhancements to existing physical access ... venues with an automated ID verification and ...
(Date:6/22/2016)... 22, 2016 On Monday, the Department of ... to share solutions for the Biometric Exit Program. The ... Border Protection (CBP), explains that CBP intends to add ... the United States , in order to ... imposters. Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
Breaking Biology News(10 mins):
(Date:6/24/2016)...  Regular discussions on a range of subjects including policies, ... entities said Poloz. Speaking at a lecture to ... he pointed to the country,s inflation target, which is set ... "In certain areas there needs ... economic goals, why not sit down and address strategy together?" ...
(Date:6/24/2016)... , June 24, 2016 Epic ... sensitively detects cancers susceptible to PARP inhibitors by ... tumor cells (CTCs). The new test has already ... therapeutics in multiple cancer types. Over ... DNA damage response pathways, including PARP, ATM, ATR, ...
(Date:6/24/2016)... ... 2016 , ... While the majority of commercial spectrophotometers and fluorometers use the ... models are higher end machines that use the more unconventional z-dimension of 20mm. ... the bottom of the cuvette holder. , FireflySci has developed several Agilent flow ...
(Date:6/24/2016)... Raleigh, NC (PRWEB) , ... June 24, 2016 , ... ... find the most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings ... here to read it now. , Diagnostic biomarkers are signposts in the blood, ...
Breaking Biology Technology: