Navigation Links
Researchers identify proteins that indicate which kidney tumors are most likely to spread
Date:12/5/2012

TORONTO, Dec. 5, 2012Researchers at St. Michael's hospital have identified 29 proteins that are likely to be involved in the spread of kidney cancer. The discovery will help physicians recognize which tumours are going to behave more aggressively and provide those patients with more intensive treatment and closer followup.

"Metastatic renal cell carcinoma is one of the most treatment-resistant malignancies and patients have dismal prognosis," said Dr. George M Yousef, a laboratory pathologist. "Identification of markers that can predict the potential of metastases will have a great impact on improvement patient outcomes.

Dr. Yousef's research appears online in the journal Molecular & Cellular Proteomics.

Kidney cancer in general is very aggressive and has a high chance of metastasis, or spreading to other organs. The five-year survival rate for metastasized kidney cancer is less than 10 per cent. Although imaging technology has led to increased detection of kidney tumours, 25 to 30 per cent have already spread by the time they are found.

Using a mass spectrometer, Dr. Yousef identified 29 proteins that change when cancer cells spread from the original site of the kidney tumour. All 29 proteins have been previously been linked to other malignancies.

Dr. Yousef said if physicians can determine which kidney tumours have those proteins, and are likely to spread, they can monitor and treat those patients more aggressively. Patients who don't have those proteins and biomarkers might not have to undergo costly and intensive treatment or surgery.

The next steps would be to find ways to stop the proteins from turning on and triggering the metastasis.


'/>"/>

Contact: Leslie Shepherd
shepherdl@smh.ca
416-864-6094
St. Michael's Hospital
Source:Eurekalert

Page: 1

Related biology news :

1. Microchoreography: Researchers use synthetic molecule to guide cellular dance
2. Einstein researchers receive 2 Grand Challenges Explorations grants to combat HIV and TB
3. University of Tennessee researchers find fungus has cancer-fighting power
4. UC Davis researchers aid effort to sequence the complex wheat genome
5. Joslin researchers increase understanding of genetic risk factor for type 1 diabetes
6. Fracking in Michigan: U-M researchers study potential impact on health, environment, economy
7. NREL researchers use imaging technologies to solve puzzle of plant architecture
8. NIH-funded researchers show possible trigger for MS nerve damage
9. Temple-Penn researchers identify calcium accelerator to keep cell power supply going
10. Researchers detail the migrations of the wood wasp Sirex noctilio
11. Researchers identify a simple way to precipitate phosphorus from the wastewater of a pulp mill
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... release is available in German . ... among the most expensive foods in the world. Because they ... them. But the distinctive smell of truffles is not only ... scientists under the direction of the Goethe University Frankfurt have ... by soil bacteria which are trapped inside truffle fruiting bodies. ...
(Date:9/30/2014)... some hope: A new research report published in October ... , explains how scientists developed a synthetic version of ... development in human and mouse eggs similar to the ... during fertilization. , "We believe that the results of ... understanding of human fertilization by providing a precise answer ...
(Date:9/30/2014)... -- Winners of The Economist,s prestigious Innovation awards 2014 ... place at the JW Marriott Hong Kong on Friday, October 10 ... their experiences and the lessons those hold for others. The awards, ... the past decade, will be presented at a ceremony in ... will be the first time the ceremony has come to ...
Breaking Biology News(10 mins):On the trail of the truffle flavor 2Synthetic sperm protein raises the chance for successful in vitro fertilization 2Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 2Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 3Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 4Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 5Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 6Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 7
... over global warming and instead reduce fossil-fuel use for the ... scientists, one from the University of Washington and one from ... in the current issue of the journal Nature ... supply will trump the environment as a reason to curb ...
... Irvine, Calif., Jan. 26, 2012 Location matters for ... UC Irvine and Wesleyan University. Findings suggest that chickadees and ... as the characteristics of their wriggly prey. Unfortunately for ... can dramatically boost their own risk of becoming food. Study ...
... for breast cancer research as well as basic cell ... Lawrence Berkeley National Laboratory (Berkeley Lab) have discovered a ... ability of breast cells to form the spherical structures ... which the researchers call "CAMo," for coherent angular motion, ...
Cached Biology News:Commentary in Nature: Can economy bear what oil prices have in store? 2Commentary in Nature: Can economy bear what oil prices have in store? 3For the birds 2Berkeley Lab researchers discover critical rotational motion in cells 2Berkeley Lab researchers discover critical rotational motion in cells 3Berkeley Lab researchers discover critical rotational motion in cells 4
(Date:10/1/2014)... This report analyzes the worldwide markets for ... following Product Segments: Proteases, Polymerases, Carbohydrases, and ... analyzed are Pharmaceuticals & Diagnostics, Research/Biotechnology, and ... comprehensive analytics for the US, Canada, Japan, ... Annual estimates and forecasts are provided for ...
(Date:9/30/2014)... Using a bio-mimicking analog of one of nature,s ... international research team led by Alejandro Briseno of ... major step in developing long-sought polymer architecture to ... use in electronic devices. , Briseno, with ... others at Stanford University and Dresden University of ...
(Date:9/30/2014)... September 30, 2014 Over the last ... due to rising R&D budgets and increased acceptance of ... growing pharmaceutical and biotechnology industries are also catalyzing the ... filtration market is expected to grow at a strong ... estimated to be worth $2,532.6 million by 2019. The ...
(Date:9/30/2014)... September 30, 2014 Fast, ... of chemistry in documents ChemAxon ... and consulting services for life science research, launches ... generate Markush structures from documents. Markush ... property, however generating and understanding Markush structures is ...
Breaking Biology Technology:Global Specialty Enzymes Industry 2Global Specialty Enzymes Industry 3Global Specialty Enzymes Industry 4Global Specialty Enzymes Industry 5Global Specialty Enzymes Industry 6Global Specialty Enzymes Industry 7Global Specialty Enzymes Industry 8Global Specialty Enzymes Industry 9Global Specialty Enzymes Industry 10Global Specialty Enzymes Industry 11Global Specialty Enzymes Industry 12Global Specialty Enzymes Industry 13Global Specialty Enzymes Industry 14Global Specialty Enzymes Industry 15Global Specialty Enzymes Industry 16Global Specialty Enzymes Industry 17Global Specialty Enzymes Industry 18Global Specialty Enzymes Industry 19Global Specialty Enzymes Industry 20Global Specialty Enzymes Industry 21Global Specialty Enzymes Industry 22Global Specialty Enzymes Industry 23Global Specialty Enzymes Industry 24Global Specialty Enzymes Industry 25Global Specialty Enzymes Industry 26Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 2Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 4Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 5ChemAxon Introduces ChemCurator for Chemical Information Extraction and Markush Structure Creation 2
... to lead ... expansion, FORT WORTH, ... today the appointment of,Michael J. "Mike" Tansey as Chief Executive Officer., ... is poised to,enter a period of accelerated growth," said Mr. Tansey. "The ...
... Chatterjee Brings Over Thirteen Years of Capital Markets ... Experience to AOBO -,- New Role Emphasizes Strategic Growth Plan and Capital ... ... Inc. (NYSE: AOB ) ("AOB" or "the Company"), a pharmaceutical,company dedicated to improving health ...
... a Hearing -, MONTVALE, N.J., June 9 ... on June 6, 2008 it received a,letter from the ... has not regained compliance with the $1.00 bid,price requirement ... to delisting from The NASDAQ Global Market, unless the ...
Cached Biology Technology:onTargetjobs Announces Appointment of Michael Tansey as New CEO 2American Oriental Bioengineering Appoints Anindya Chatterjee to Chief Strategy Officer 2American Oriental Bioengineering Appoints Anindya Chatterjee to Chief Strategy Officer 3Memory Pharmaceuticals Receives Anticipated NASDAQ Staff Determination Letter 2Memory Pharmaceuticals Receives Anticipated NASDAQ Staff Determination Letter 3
MOUSE ANTI SIMIAN VIRUS 5 Immunogen: Simian virus 5...
... Dog Serum-Mixed Breed • Dog serum is collected ... one year of age Available Anticoagulants: ... (Na) N-06: K2EDTA N-08: ... N-03: Alsevers N-05: ACD ...
Ready-to-use; 40mg/ml X-Gal and 32mg/ml IPTG...
Whole blood is collected from canines (any breed, either sex), refrigerated within 6 hours, processed within 24 hours and frozen at -20C....
Biology Products: