Navigation Links
Researchers identify possible receptor for key breast cancer regulator
Date:1/13/2012

A key protein potentially involved in regulating breast cancer progression has been identified by researchers at Clarkson University in Potsdam, N.Y. Led by professor Costel Darie, the team worked to identify the binding partner of Tumor Differentiating Factor (TDF), a pituitary hormone that had previously been shown to reduce cancer progression in breast cancer cells.

Earlier studies had shown that breast cancer cells treated with TDF lost their cancerous characteristics and began acting like normal mammary cells, suggesting that TDF had tumor-suppressing capabilities. However, how TDF acted remained unclear, leading Darie's group to initiate a search for a cellular receptor in cancer cells that might bind TDF and transmit its anti-tumorigenic cues.

Darie's group found that a receptor, labeled TDF-R, was found exclusively in breast, but not other cancer, cells, suggesting a level of specificity that agrees with previous reports of the efficacy of TDF. This result, which is being reported in a forthcoming issue of the Journal of Biological Chemistry, has substantial potential implications for developing new therapies for treating breast cancers known to be unresponsive to standard steroid hormone-based therapies, such as tamoxifen treatment.

Looking toward the next step, Darie asserted that "finding the receptor for the TDF hormone will allow us to rationally design drugs that will have a potent ability to stop cancer progression." He continued, "We will also be able to use TDF as a biomarker for breast cancer onset, thereby improving diagnoses."

Though cancer incidence and mortality rates have declined over the past 30 years, breast cancer remains a major killer: In 2007, breast cancer accounted for about 40,000 deaths in the U.S., while another 200,000 women were diagnosed, according to the Center for Disease Control.


'/>"/>
Contact: Geoff Hunt
ghunt@asbmb.org
240-283-6626
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... Md. , June 22, 2016  The American College ... Trade Show Executive Magazine as one of the ... on May 25-27 at the Bellagio in Las ... on the highest percentage of growth in each of the ... of exhibiting companies and number of attendees. The 2015 ACMG ...
(Date:6/22/2016)... On Monday, the Department of Homeland Security (DHS) issued ... the Biometric Exit Program. The Request for Information (RFI), ... that CBP intends to add biometrics to confirm when ... , in order to deter visa overstays, to ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/20/2016)... , June 20, 2016 Securus ... justice technology solutions for public safety, investigation, corrections ... the prisons involved, it has secured the final ... (DOC) facilities for Managed Access Systems (MAS) installed. ... additional facilities to be installed by October, 2016. ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... , ... June 24, 2016 , ... Researchers at the ... commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the subject ... it now. , Diagnostic biomarkers are signposts in the blood, lung fluid or ...
(Date:6/23/2016)... SILVER SPRING, Md. , June 23, 2016 ... evidence collected from the crime scene to track the criminal ... sick, and the U.S. Food and Drug Administration (FDA) uses ... Sound far-fetched? It,s not. ... whole genome sequencing to support investigations of foodborne illnesses. Put ...
(Date:6/23/2016)... FRANCISCO , June 23, 2016   EpiBiome ... has secured $1 million in debt financing from Silicon ... ramp up automation and to advance its drug development ... its new facility. "SVB has been an ... beyond the services a traditional bank would provide," said ...
(Date:6/23/2016)...  Blueprint Bio, a company dedicated to identifying, protecting ... has closed its Series A funding round, according to ... "We have received a commitment from Forentis Fund that ... meet our current goals," stated Matthew Nunez . ... complete validation on the current projects in our pipeline, ...
Breaking Biology Technology: