Navigation Links
Researchers identify possible receptor for key breast cancer regulator
Date:1/13/2012

A key protein potentially involved in regulating breast cancer progression has been identified by researchers at Clarkson University in Potsdam, N.Y. Led by professor Costel Darie, the team worked to identify the binding partner of Tumor Differentiating Factor (TDF), a pituitary hormone that had previously been shown to reduce cancer progression in breast cancer cells.

Earlier studies had shown that breast cancer cells treated with TDF lost their cancerous characteristics and began acting like normal mammary cells, suggesting that TDF had tumor-suppressing capabilities. However, how TDF acted remained unclear, leading Darie's group to initiate a search for a cellular receptor in cancer cells that might bind TDF and transmit its anti-tumorigenic cues.

Darie's group found that a receptor, labeled TDF-R, was found exclusively in breast, but not other cancer, cells, suggesting a level of specificity that agrees with previous reports of the efficacy of TDF. This result, which is being reported in a forthcoming issue of the Journal of Biological Chemistry, has substantial potential implications for developing new therapies for treating breast cancers known to be unresponsive to standard steroid hormone-based therapies, such as tamoxifen treatment.

Looking toward the next step, Darie asserted that "finding the receptor for the TDF hormone will allow us to rationally design drugs that will have a potent ability to stop cancer progression." He continued, "We will also be able to use TDF as a biomarker for breast cancer onset, thereby improving diagnoses."

Though cancer incidence and mortality rates have declined over the past 30 years, breast cancer remains a major killer: In 2007, breast cancer accounted for about 40,000 deaths in the U.S., while another 200,000 women were diagnosed, according to the Center for Disease Control.


'/>"/>
Contact: Geoff Hunt
ghunt@asbmb.org
240-283-6626
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... MOUNTAIN VIEW, Calif. , July 30, 2015 ... products and services for gene function analysis and ... CRISPR Guide RNA (sgRNA) Knockout Library targeting all ... to specifically and permanently "knock out" a gene,s ... library provides a high throughput screening tool so ...
(Date:7/23/2015)... Aware, Inc. (NASDAQ: AWRE ), a leading ... for its second quarter ended June 30, 2015.  ... million, a decrease of 33% compared to $6.8 million in ... quarter of 2015 was $0.3 million, or $0.01 per diluted ... share, in the same period a year ago.  ...
(Date:7/21/2015)... July 21, 2015  NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce ... announces that it has filed provisional patent 62/192218 ... This invention highlights next generation ... an account, but also the user using unique ...
Breaking Biology News(10 mins):CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 2NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 4
... spontaneous organised motion of a large number of individuals. It ... and groups of insects to shoals of fish, flocks of ... Lobaskin from University College Dublin, Ireland, have uncovered new collective ... EPJ B . Ultimately, this could be used to ...
... only species with a sweet tooth. Research from North Carolina ... Drosophila suzukii ) also prefers sweet, soft fruit giving ... the United States over the past four years and threatens ... U.S. fruit crops. "Because we know that D. ...
... an extinct Australian frog has been revived and reactivated by ... a "dead" cell nucleus into a fresh egg from another ... which uniquely swallowed its eggs, brooded its young ... became extinct in 1983., But the Lazarus Project team has ...
Cached Biology News:Study offers new insights on invasive fly threatening US fruit crops 2Lost frog DNA revived: Lazarus Project 2
(Date:8/3/2015)... (PRWEB) , ... August 03, 2015 , ... Nine field ... Iowa, Illinois and Indiana. Hosted by the Soil Health Partnership , the field ... lasting environmental benefits while potentially increasing farm productivity and income. , Brent Bible has ...
(Date:8/3/2015)... GERMANTOWN, Md. , Aug. 3, 2015   ... it will release first half and second quarter 2015 ... 10 th , 2015.  The Company will host a ... results and provide a general business update. ... (Domestic US) and 1-412-902-4262 (International), and asking to join ...
(Date:8/3/2015)... Kent, WA (PRWEB) , ... August 03, 2015 ... ... TLD3000 and TLD5000 diaphragm vacuum pumps to its comprehensive line of analytical laboratory ... stainless steel valves, these versatile pumps provide a chemically resistant and maintenance-free solution ...
(Date:7/31/2015)... China Cord Blood Corporation (NYSE: CO) ("CCBC" ... provider of cord blood collection, laboratory testing, hematopoietic stem ... that the Company has filed its Annual Report on ... The filed Form 20-F includes audited financial statements for ... 20-F can be accessed by visiting the U.S. Securities ...
Breaking Biology Technology:Soil Health Field Days Kick Off Throughout Midwest 2Soil Health Field Days Kick Off Throughout Midwest 3Intrexon to Announce First Half and Second Quarter 2015 Financial Results and Host Conference Call on August 10th 2Sterlitech Launches New Line of Vacuum Pumps 2China Cord Blood Corporation Files Its Annual Report on Form 20-F 2
... ... will take place on May 16-19, 2010 in Baltimore, MD, USA. This innovative ... their knowledge and experience in process development, crystallization, safety, scale-up, production, and emerging technologies. ... Columbia, MD ...
... Scientists at Queen,s University Belfast are developing new sensors to ... the fight against the threat of terrorist attacks. The ... or crime scene to gather a sample which is then ... of chemicals within seconds. This will allow better, faster decisions ...
... Batteries can power anything from small sensors to ... them smaller but even more powerful, problems can arise ... the devices themselves. University of Missouri researchers are developing ... more efficient. "To provide enough power, we need ...
Cached Biology Technology:17th International Process Development Conference to Feature Presentations on Safety, Process Development, Crystallization, PAT, Scale-Up and Production 2New technology detects chemical weapons in seconds 2Researchers create smaller and more efficient nuclear battery 2
... Corning single use spatulas have been designed ... They are for those interested in eliminating ... spatulas. Each spatula is individually packaged, RNase/DNase ... number is a new product number, created ...
... three-way universal digital valve, just 8 mm in ... functional features in a single glass-reinforced, PBT (Polybutylene ... 8mm in width. , Meets a range of ... psi. , Satisfies a 0.016 sccm leakage specification ...
... versatile system that simultaneously harvests and washes ... into a solid filter supports for analysis ... counter. The FilterMate is ideal for the ... cell proliferation, receptor binding, nucleic acid degradation, ...
... for use with dishes and cell culture ... new product number, created to easily match ... yet, please order under the old Sigma-Aldrich ... assistance. Comp Dim: blade L 1.9 cm ...
Biology Products: