Navigation Links
Researchers identify new role for cilia protein in mitosis
Date:4/4/2011

WORCESTER, Mass. Researchers at the University of Massachusetts Medical School have described a previously unknown role for the cilia protein IFT88 in mitosis, the process by which a dividing cell separates its chromosomes containing the cell's DNA into two identical sets of new daughter cells. Published in advance online by Nature Cell Biology, this newly discovered function for IFT88 suggests a possible alternative or contributory cause for cilia-related diseases such as primary ciliary dyskinesia, and polycystic kidney disease.

Famous for its ability to build cilia, a slender protrusion responsible for motility and sensory input, IFT88 is part of a family of transport proteins and cellular machinery that is responsible for moving materials from the cell body to the cilia. These cellular materials are necessary for the proper formation and maintenance of cilia and in the absence of IFT88 cilia are either unable to form or are defective. Over the last several years, scientists have linked cilia dysfunction to a number of diseases now known as ciliopathies. In particular, the loss of IFT88, one of the best-studied cilia proteins, has been associated with polycystic kidney disease (PKD). PKD is characterized by the presence of multiple cysts in the kidneys and is believed to be caused by cilia dysfunction in kidney cells.

Stephen J. Doxsey, PhD, professor of molecular medicine and biochemistry & molecular pharmacology and cell biology and lead author of the study, shows that IFT88 also plays an important role in mitosis. Doxsey and colleagues at UMass Medical School observed that the IFT88 protein is present at the poles of the mitotic spindle, structures which form during mitosis and are required to guide chromosome sets as the cell divides in two and to orient the plane of cell division. He hypothesized that the cilia protein played a transport function during mitosis that was similar to that in cilia.

"We knew that IFT88 and several other proteins in this family were present at spindle poles during mitosis but we didn't know what function, if any, they served," said Doxsey."

Benedicte Delaval, PhD, a postdoctoral fellow in Doxsey's lab and first author of the Nature Cell Biology paper added, "What we found is that IFT88 plays a part in the transport of materials required for building the spindle poles during cell division. The loss of IFT88 protein during mitosis caused a delay in mitotic division and misalignment of the direction and plane of cell division.

This finding raises the possibility that mitotic dysfunction may play a role in previously described cilia-related disorders caused by the same family of IFT proteins. "It appears that the cellular machinery used in cilia formation is very similar to the machinery used in mitosis," said Doxsey. "This new and distinct function for IFT88 suggests that disruption of both cilia and mitosis could co-contribute to ciliopathies."

Since both cilia and spindles arise from a structure in the cell called the centrosome, Doxsey hypothesizes that there may be some underlying defect to the centrosome responsible for both processes going awry. "It's possible that cilia defects alone might actually explain only part of the disease especially in the kidney," said Doxsey. "At this point, we don't know. What we do know is that IFT88's role in mitosis has yet to be fully explored. It appears, though, to play a similar role in two different functions. We need to take a more global look at the cell to determine what precisely is going on in this family of disorders."


'/>"/>

Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert

Related biology news :

1. Researchers link herpes to Alzheimers disease
2. Researchers say children need horticultural interventions
3. Berkeley Lab researchers make first perovskite-based superlens for the infrared
4. Kentucky researchers find a key to plant disease resistance
5. Researchers unlock new secret to how smells are detected
6. RIT researchers help map tsunami and earthquake damage in Japan
7. Dont shuffle on slippery surfaces, Clemson University, Charleston researchers say
8. U of M researchers close in on technology for making renewable petroleum
9. Heinz Maier-Leibnitz Prizes 2011: Recognition and incentive for early career researchers
10. MU researchers use motion sensors to determine equine lameness
11. PMH researchers create an organic nanoparticle that uses sound and heat to find and treat tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/29/2016)... Nearly one billion matches per second with DERMALOG,s ... ... DERMALOG is Germany's largest Multi-Biometric ... Management. (PRNewsFoto/DERMALOG Identification Systems) ... DERMALOG is Germany's largest Multi-Biometric supplier: The company's Fingerprint Identification System is ...
(Date:11/22/2016)... Minn. , Nov. 22, 2016   MedNet ... supports the entire spectrum of clinical research, is pleased ... Medical LiveWire Healthcare and Life Sciences Awards ... award caps off an unprecedented year of recognition and ... trials for over 15 years. iMedNet ...
(Date:11/17/2016)...  AIC announces that it has just released a new white paper authored by ... plus high speed data transfer storage solutions. Photo - http://photos.prnewswire.com/prnh/20161116/440463 ... ... ... Setting up a high performance computing or HPC system can ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... DIEGO , Dec. 8, 2016  Biotheranostics ... demonstrating the role of the Breast Cancer Index ... ER+ breast cancer are most at-risk for disease ... Data include results from three studies advancing the ... information related to tumor biology and inform decisions ...
(Date:12/8/2016)... 2016 Oxford Gene ... seine Palette an anpassbaren SureSeq™ NGS-Panels mit dem ... das ein schnelles und kostengünstiges Studium der Varianten ... eine Erkennung von Einzel-Nukleotid-Variationen (Single Nucleotide Variation, SNV) ... kleinen Panel und ermöglicht eine individuelle Anpassung durch ...
(Date:12/8/2016)... CA (PRWEB) , ... December 08, 2016 , ... ... as finalists in the World Technology Awards. uBiome is one of just six ... across all categories. , In addition to uBiome, companies nominated as finalists in ...
(Date:12/8/2016)... 2016 Savannah River Remediation LLC group ... NewTechBio,s NT-MAX Lake & Pond Sludge and ... in conjunction with Hexa Armor/ Rhombo cover manufactured ... Pollutant Discharge Elimination System requirements. The ... history of elevated pH levels, above 8.5, especially ...
Breaking Biology Technology: