Navigation Links
Researchers identify new risk factor gene for rheumatoid arthritis
Date:6/9/2009

Scientists at The Feinstein Institute for Medical Research and a team of collaborators from across the country have identified a new risk factor gene for rheumatoid arthritis. The paper will be published in Nature Genetics and the finding brings light to the nature of the disease. The gene, dubbed REL, is a member of the NF-B family, important transcription factors that have many roles in the body. The NF-B family seems to have a big hand in regulating the body's immune response as well.

"The NF-is a key switching point for many cellular activities," said Peter K. Gregersen, MD, head of the Robert S. Boas Center for Genomics and Human Genetics at the Feinstein Institute and lead author of the study. Dr. Gregersen is part of a nationwide consortium of investigators seeking to identify risk genes for rheumatoid arthritis (RA). The hope is to figure out the genetic triggers and identify treatments that block this autoimmune process. In theory, such advances can point the way to understanding other autoimmune disorders. About one percent of the population will develop rheumatoid arthritis, which can be crippling.

REL is a key regulator of CD40, which works through the NF-pathway.

"This paper represents the latest in a series of important publications chronicling an exceptionally productive collaboration between extramural and intramural scientists through the North American Rheumatoid Arthritis Consortium," said Daniel Kastner, MD, PhD, clinical director of the National Institute of Arthritis and Musculoskeletal and Skin Diseases. "In describing yet another gene in the CD40 signaling pathway that is involved in rheumatoid arthritis susceptibility, this paper reinforces the possibility of targeting this pathway in selected patients with this debilitating illness."

The consortium has helped identify many genes involved in rheumatoid arthritis but this genetic
'/>"/>

Contact: Jamie Talan
jtalan@nshs.edu
516-562-1232
North Shore-Long Island Jewish (LIJ) Health System
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers shed light on trading behavior in animals -- and humans
2. University of Saskatchewan and Canadian Synchrotron researchers shed light on esophageal disease
3. Faculty of Translational Medicine boosts support for biomedical researchers
4. USC researchers present diabetes findings at American Diabetes Association Scientific Sessions
5. MSU researchers receive $400,000 in first wave of stimulus funding
6. Researchers engineer metabolic pathway in mice to prevent diet-induced obesity
7. Elevated water temperature and acidity boost growth of key sea star species: UBC researchers
8. Penn researchers discover genetic risk factor for testicular cancer
9. Understanding plants overactive immune system will help MU researchers build better crops
10. Notre Dame researchers describe new tool for evaluating managed relocations
11. UCSD researchers make first direct observations of biological particles in high-altitude ice clouds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... algal forests in the eastern Mediterranean Sea pose a ... distribution continues to expand as the climate warms, a ... of researchers led by Dr Adriana Vergs of UNSW ... for Advanced Studies in Spain, is published in the ... surveyed more than 1000 kilometres of coastline in Turkey ...
(Date:9/18/2014)... 2014 Elsevier, a world-leading provider of scientific, ... the Australasian Research Management Society (ARMS), recognized the ... the 5th Scopus Young Researcher of the Year ... at the National Convention Centre and in conjunction ... by guests representing Australia,s and New Zealand,s scientific ...
(Date:9/18/2014)... of the fish world, are the ideal animal in ... They,ve moved from the ocean into tens of thousands ... time changing their skeleton to adapt to the new ... of sticklebacks now have turned up one of the ... simple change in that gene,s regulation in a freshwater ...
Breaking Biology News(10 mins):Tropical fish a threat to Mediterranean Sea ecosystems 2Elsevier and Australasian Research Management Society award scientists at Scopus ceremony 2Counting fish teeth reveals regulatory DNA changes behind rapid evolution, adaptation 2Counting fish teeth reveals regulatory DNA changes behind rapid evolution, adaptation 3
... research group of Dr. Frdric Charron, a researcher at the ... discovery which could help treat spinal cord injuries and neurodegenerative ... issue of the prestigious scientific journal Neuron . Patricia ... the IRCM, are listed as co-authors. The brain is ...
... of the most successful scientists within stem cell research, ... for biotech and pharmaceuticals, BIO 2009 in Atlanta, USA. ... Karolinska Institutet, SwedenBIO and Invest in Sweden Agency. ... one of the most exciting areas in science, and ...
... years ago, it was discovered that bacteria known as ... antibiotics have become the primary therapy used to combat the ... of the world population and is also a primary cause ... resistant to antibiotics. Now a study led by ...
Cached Biology News:Identification of a key molecular pathway required for brain neural circuit formation 2Glutamine supplements show promise in treating stomach ulcers 2Glutamine supplements show promise in treating stomach ulcers 3
(Date:9/19/2014)... 2014 BioTech News Coverage: Progress ... results of studies and trials.  Companies in focus are: ... LLY ), Gilead Sciences Inc. (NASDAQ: ... ) and Arena Pharmaceuticals Inc. (NASDAQ: ARNA) ... therapeutics for the treatment of cancer, announced that the ...
(Date:9/19/2014)... , The first grants awarded ... Endocrinology (ESPE) Meeting  Investment supports innovative projects ... the field of growth  , EMD Serono, ... , today announced the first recipients of the ... were announced during a Satellite Symposium organized by EMD ...
(Date:9/18/2014)... LONDON , Sept. 18, 2014 ... near-patient testing, is performed outside a clinical laboratory. ... hence in administrating appropriate treatments and medication. POCT ... and prevalence of lifestyle diseases such as diabetes, ... and user-friendly. POCT devices are standardized to minimize ...
(Date:9/18/2014)... , September 18, 2014 /PRNewswire/ ... Markets ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has announced ... Materials - Global Strategic Business Report" ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,This report analyzes the ... US$ Million by the following Product ...
Breaking Biology Technology:Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 2Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 3Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 4Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 5Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 6Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 7EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 3POCT Market in China 2014-2018 2Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3
... begun using a network infrastructure developed by Citrix ... over the Internet from a central office, the company ... able to provide 1,600 government employees across 45 departments ... from remote locations, including their homes, according to a ...
... - Working to help cell-phone users take advantage of ... University of Wisconsin-Madison engineers have developed a device that ... on even less battery power. , ,"When you've been ... you can feel how hot it gets," notes Zhenqiang ...
... an Internet search page: top, middle and down. A search ... times its 100 feet long. Today, e-commerce is like a ... then will it will float on the surface and be ... submarine, it will stay caught in some mysterious undercurrents or ...
Cached Biology Technology:Dane County improves law enforcement and community services 2UW-Madison technology to advance cell phones 2UW-Madison technology to advance cell phones 3Does your web site have visibility? 2Does your web site have visibility? 3
Antibodies were affinity purified using epitopes specific to JLP immobilized on solid support....
This issue concentrated on the purification of proteins for specific purposes (i.e. large-scale purification, purification for therapeutic use, etc.)...
Edited by D. Patel (1994) Comprehensive data on gel electrophoresis of proteins, nucleic acids, nucleoproteins and carbohydrates....
The Protein Kinase Factsbooks (2 Volume Set)...
Biology Products: