Navigation Links
Researchers identify new regulator in allergic diseases
Date:3/28/2012

CINCINNATI - Researchers have taken a critical step in understanding how allergic reactions occur after identifying a genetic signature for regulation of a key immune hormone, interleukin (IL-13).

Scientists from Cincinnati Children's Hospital Medical Center say the finding opens the potential for new molecular targets to treat allergic disease. They report on March 28 in Mucosal Immunology that a particular microRNA, miR-375, is regulated by IL-13, and in turns regulates how IL-13 induces pro-allergic changes, particularly in epithelial cells in the lung and esophagus.

The data support a role for miR-375 in asthma and in eosinophilic esophagitis (EoE), a severe, often painful food allergy that renders children unable to eat a wide variety of foods. EoE can also cause weight loss, vomiting, heartburn and swallowing difficulties.

"The identification of a microRNA that regulates IL-13-induced changes and inflammatory pathways is a significant advancement for the understanding and future treatment of allergic disease," says Marc E. Rothenberg, MD, senior investigator on the study and director of the Division of Allergy and Immunology and Center for Eosinophilic Disorders at Cincinnati Children's. "MiR-375 is proof of principle that microRNAs are involved in fine-tuning IL-13-mediated responses, which opens up a set of new possibilities for novel therapeutic targets for treatment of allergic disease."

IL-13 induces changes in epithelial gene and protein expression that are important in the onset of many allergic diseases, including EoE. Notably, expression of miR-375 was consistently downregulated after IL-13 stimulated human esophageal squamous and bronchial epithelial cells. Viral overexpression of miR-375 in epithelial cell cultures markedly modified the IL-13-associated immunoinflammatory pathways.

MicroRNAs are short segments of RNA that can regulate whether genetic messengers (mRNAs) are degraded or transl
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... the natural history museums of the world are billions ... beetles to flowers, mushrooms and grasses, all stacked, stored ... rich and diverse collections could be critical to understanding ... of a growing human footprint if only the ... brought to life with the help of a team ...
(Date:5/23/2013)... Publishing in Neuron , the team reveal the ... in work funded by the Wellcome Trust and BBSRC. ... external stimuli we improve our perceptual abilities. While these ... they can also affect the fidelity of that response. ... Visual Neuroscience explains: "When you communicate with others, you ...
(Date:5/22/2013)... 2013 U.S. Forest Service scientists are part of ... from the TKF Foundation, will examine how collaborative planning ... recover from tragedy. , The TKF Foundation announced today ... selected for grant funding. In addition to research on ... recovery and resiliency, the 3-year, $585,000 grant will contribute ...
Breaking Biology News(10 mins):CU-Boulder helps tap crowds to digitize museum records of bugs and plants 2CU-Boulder helps tap crowds to digitize museum records of bugs and plants 3CU-Boulder helps tap crowds to digitize museum records of bugs and plants 4'Landscapes of Resilience' to study how people use nature as a source of recovery 2
... the dynamics of a deadly disease that is wiping ... today in the Proceedings of the National Academy ... severity of the disease among individuals -- determines whether ... fungal disease called Chytridiomycosis . The research identifies ...
... been a hard winter for Monarch butterflies, according to Chip ... Taylor said that low temperatures, storms and habitat destruction have ... "I spend a lot of time fretting over the status ... or data that will help me understand the past as ...
... at the University of Michigan Comprehensive Cancer Center ... neck cancer to avoid treating critical structures that ... these principles and techniques treated the cancer effectively ... researchers applied highly conformal, intensity-modulated radiation therapy and ...
Cached Biology News:New insights into how deadly amphibian disease spreads and kills 2New insights into how deadly amphibian disease spreads and kills 3New insights into how deadly amphibian disease spreads and kills 4As monarch butterflies journey north, gardeners can help protect species, researcher says 2U-M study achieves reduced side effects in head and neck cancer treatment 2
(Date:5/24/2013)... SAN DIEGO , May 24, 2013 ... a  company using proprietary taste science technologies to discover, ... David Linemeyer , Ph.D., the Company,s ... , Vice President, Investor Relations & Corporate Communications, will ... Friday, May 31, at 10:25 a.m. Eastern Time (7:25 ...
(Date:5/24/2013)... Toronto, Canada (PRWEB) May 24, 2013 ... selective barriers, and uptake or efflux transporters at the ... may be related to unbound fractions in the tissue ... understanding of these disposition challenges is required to guide ... and to identify any species-dependent variables that may impact ...
(Date:5/24/2013)... 24, 2013 Vestiage, Inc. (stock ... focused on science-based research and development, sales and ... and nutraceuticals, announced today that it is awarding ... the sale of Reluma Skin Illuminating Facial Care. ... application by sending an email to info(at)vestiageinc(dot)com and ...
(Date:5/23/2013)... England , May 24, 2013 ... Mundipharma angefertigt – Bei der ... , 91 % der Teilnehmer einer groß ... nur 20 % laut GINA [*] -Definition [1] ... dass Menschen mit Asthma generell einer von vier Denkweisen ...
Breaking Biology Technology:SENOMYX TO WEBCAST CORPORATE PRESENTATION AT THE CITI 2013 GLOBAL CONSUMER CONFERENCE 2DMPK for Targeted Tissue Delivery: Solutions for the Most Challenging Part of Outsourcing, New Life Science Webinar Hosted by Xtalks 2Vestiage Announces Launch of Exclusive Territories for Reluma Brand Sales in USA 2Vestiage Announces Launch of Exclusive Territories for Reluma Brand Sales in USA 3Vestiage Announces Launch of Exclusive Territories for Reluma Brand Sales in USA 4Vestiage Announces Launch of Exclusive Territories for Reluma Brand Sales in USA 5Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 2Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 3Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 4Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 5Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 6Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 7
... Watch out, iPod and Sirius Radio; here comes Motorola. The company ... or commercial-free Internet radio through your cell phone. You can play ... your car or on your home stereo and transition from ... WTN's Mike Klein traveled to Arizona to get the scoop. Original ...
... merged with STI Knowledge, an Atlanta-based provider of ... BPO company with offices in Norristown, Pennsylvania; Scottsdale, ... off from its parent Symphony Corp. , ,Symphony ... BPO services, with a particular expertise in the ...
... and Intermountain Health Care (IHC) have announced ... would accelerate the adoption of electronic health records among ... the annual Healthcare Information and Management Systems Society (HIMSS) ... take the clinical knowledge that IHC has gathered over ...
Cached Biology Technology:GE and Intermountain want to streamline nationwide patient data 2
MAb to Yersinia pestis F1 Ag. Yersinia pestis F1 Antigen EB Strain...
Mouse monoclonal antibody to QDPR - quinoid dihydropteridine reductase...
... Signets FAST RED Chromogen System consists of ... RED reacts in the presence of alkaline ... background noise. The FAST RED System ... ,The System Contains: , , Vial A: ...
The BioLogic Maximizer mixer is for use with the Maximizer valve system. The mixer improves gradient quality by mixing the output of the BioLogic DuoFlow workstation pumps....
Biology Products: