Navigation Links
Researchers identify new regulator in allergic diseases
Date:3/28/2012

CINCINNATI - Researchers have taken a critical step in understanding how allergic reactions occur after identifying a genetic signature for regulation of a key immune hormone, interleukin (IL-13).

Scientists from Cincinnati Children's Hospital Medical Center say the finding opens the potential for new molecular targets to treat allergic disease. They report on March 28 in Mucosal Immunology that a particular microRNA, miR-375, is regulated by IL-13, and in turns regulates how IL-13 induces pro-allergic changes, particularly in epithelial cells in the lung and esophagus.

The data support a role for miR-375 in asthma and in eosinophilic esophagitis (EoE), a severe, often painful food allergy that renders children unable to eat a wide variety of foods. EoE can also cause weight loss, vomiting, heartburn and swallowing difficulties.

"The identification of a microRNA that regulates IL-13-induced changes and inflammatory pathways is a significant advancement for the understanding and future treatment of allergic disease," says Marc E. Rothenberg, MD, senior investigator on the study and director of the Division of Allergy and Immunology and Center for Eosinophilic Disorders at Cincinnati Children's. "MiR-375 is proof of principle that microRNAs are involved in fine-tuning IL-13-mediated responses, which opens up a set of new possibilities for novel therapeutic targets for treatment of allergic disease."

IL-13 induces changes in epithelial gene and protein expression that are important in the onset of many allergic diseases, including EoE. Notably, expression of miR-375 was consistently downregulated after IL-13 stimulated human esophageal squamous and bronchial epithelial cells. Viral overexpression of miR-375 in epithelial cell cultures markedly modified the IL-13-associated immunoinflammatory pathways.

MicroRNAs are short segments of RNA that can regulate whether genetic messengers (mRNAs) are degraded or transl
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... , May 21, 2015 The ... potential of music for health, today announced a collaborative ... . The partnership will center on collaboration on original ... a first step in the collaboration, The Sync Project ... on "Music as Medicine" in the 2015-2016 academic year.  ...
(Date:5/20/2015)... May 20, 2015 NXT-ID, Inc. (NASDAQ: ... wholly owned subsidiary, 3D-ID LLC, a company engaged in ... for the biometrics technology portion of the recently awarded ... the Department of the Army. 3D-ID LLC ... for government, law enforcement and security agencies. ...
(Date:5/19/2015)... 2015  Technology is rapidly advancing, outpacing enterprises, ability ... cloud. Passwords and their management are soon to be ... specifications such as those developed by the FIDO Alliance™. ... presents for BYOD, COPE, IoT, and mobile payments, the ... In response to the call for ...
Breaking Biology News(10 mins):The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 2The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 3NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3
... tracking technology, conservationists from the Wildlife Conservation Society, the University ... a ground-breaking study on a mysterious ocean giant: the manta ... published study on the use of satellite telemetry to track ... grow up to 25 feet in width. Researchers say ...
... Barley grown in Scandinavian countries is adapted in a similar ... length at high latitudes. Researchers have found a genetic mutation ... that barley from southern regions use to time their growing ... to extremely long days, so has Scandinavian barley to grow ...
... show that embryonic stem cells unable to fully compact ... differentiation into specific cell types that give rise to ... body. Researchers from the Georgia Institute of Technology ... for proper embryonic stem cell differentiation to occur. Chromatin, ...
Cached Biology News:First satellite tag study for manta rays reveals habits and hidden journeys of ocean giants 2Barley takes a leaf out of reindeer's book in the land of the midnight sun 2Barley takes a leaf out of reindeer's book in the land of the midnight sun 3Successful stem cell differentiation requires DNA compaction, study finds 2Successful stem cell differentiation requires DNA compaction, study finds 3Successful stem cell differentiation requires DNA compaction, study finds 4
(Date:5/27/2015)... , May 27, 2015  Northwest Biotherapeutics, Inc. (NASDAQ: ... DCVax® personalized immune therapies for cancer, announced today that ... of the Company, will be making an Industry Expert ... Chicago on Saturday, May 30, ... Industry Expert Theater in McCormick Place. Dr. ...
(Date:5/27/2015)... May 27, 2015  RXi Pharmaceuticals Corporation (NASDAQ: ... discovering and developing innovative therapies primarily in the ... on the status of the Company,s Series A ... Logo - http://photos.prnewswire.com/prnh/20130917/NE80755LOGO ... 21 shares of Series A Preferred Stock and ...
(Date:5/26/2015)... 2015 Regenestem Network has ... clinic in Buenos Aires, Argentina. The clinic will be ... specialist. Pastrana has assembled a multidisciplinary team of medical ... her state-of-the-art Puerto Madero office. , The new ... phase IV clinical studies in cellular therapies, and establish ...
(Date:5/26/2015)... REDWOOD CITY, California and HILDEN, ... -- QIAGEN N.V. (NASDAQ: QGEN ... commercial launch of its QIAGEN Clinical Insight ® ... clinical testing labs to interpret and report on ... first two supported applications for the bioinformatics platform ...
Breaking Biology Technology:NW Bio To Present Overview Of DCVax-Direct Phase I Trial In Chicago This Weekend 2NW Bio To Present Overview Of DCVax-Direct Phase I Trial In Chicago This Weekend 3RXi Pharmaceuticals Provides an Update on Series A and Series A-1 Preferred Stock 2RXi Pharmaceuticals Provides an Update on Series A and Series A-1 Preferred Stock 3Regenestem Network and Silvina Pastrana, M.D. Announce the Opening of a New Stem Cell Clinic in Buenos Aires 2Regenestem Network and Silvina Pastrana, M.D. Announce the Opening of a New Stem Cell Clinic in Buenos Aires 3QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 2QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 3QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 4QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 5
... An education research team at the University of Wisconsin-Madison ... to study the impact of digital media on youth ... investment will support 24 national studies of different aspects of ... , ,"What MacArthur is actually trying to do, with this ...
... this column before the American population hit the 300 million mark ... - America's population is scheduled to hit the 300 million mark ... guilt-trip the poor baby before he or she is out of ... the contrary, too many environmentalists still buy into the doomsday theories ...
... Court soon will decide whether to change the current ... must not be "obvious" in light of what was publicly ... and any change in the legal test for obviousness would ... ,One only has to look at the list of non-party ...
Cached Biology Technology:UW gets $3M to explore educational gaming 2UW gets $3M to explore educational gaming 3300 millionth American no cause for eco-alarm 2300 millionth American no cause for eco-alarm 3300 millionth American no cause for eco-alarm 4Inventions could fall prey to Monday morning quarterbacking 2Inventions could fall prey to Monday morning quarterbacking 3Inventions could fall prey to Monday morning quarterbacking 4
DNA Purification...
EPH electrode, cathode, 1. Category: Electrophoresis Systems & Standards & Reagents, IEF & SDS-PAGE & 2-D Electrophoresis, Multiphor II Kits & Components and Accessories....
... Guinea Pig serum is collected from fasted Guinea ... Citrate N-04: Heparin (Na) ... N-10: EDTA (Na) N-03: ... CPD N-09: K3EDTA N-11: ...
... ml. Improves reproducibility and quality ... streaking.Eliminates extra spots caused by ... throughout entire 2-D runs, ensuring ... for both analytical and preparative ...
Biology Products: