Navigation Links
Researchers identify new gene involved in the development of liver cancer
Date:4/19/2010

RICHMOND, Va. (April 19, 2010) Virginia Commonwealth University researchers have identified a new tumor-promoting gene that may play a key role in the development of liver cancer. Levels of the gene's expression are significantly higher in more than 90 percent of patients with the disease compared to their healthy counterparts.

Researchers at the Virginia Commonwealth University Massey Cancer Center and the VCU Institute of Molecular Medicine hope the findings could lead to an effective therapy to target and inhibit the expression of this gene and result in inhibition of cancer growth.

Hepatocellular carcinoma, HCC, or liver cancer, is the fifth most common cancer and the third leading cause of cancer deaths in the world. Treatment options for HCC include chemotherapy, chemoembolization, ablation and proton-beam therapy. Liver transplantation offers the best chance for a cure in patients with small tumors and significant associated liver disease.

In the study published online the week of April 19 in the Early Edition of the journal Proceedings of the National Academy of Sciences, researchers employing a series of molecular studies identified the new oncogene called LSF, and observed that LSF levels are significantly higher in HCC patients compared to healthy individuals.

Further, the team found that LSF plays an important role in the development and progression of HCC, and that inhibiting LSF can reverse the aggressive properties of human liver cancer cells. They have also identified the molecular mechanism by which LSF promotes the growth of tumors.

"Researchers have been studying the role of LSF for more than 25 years in fields outside of cancer, but our work is the first demonstration that LSF plays an important role in HCC," said principal investigator Devanand Sarkar, Ph.D., MBBS, assistant professor in the Department of Human and Molecular Genetics in the VCU School of Medicine, and Harrison Endowe
'/>"/>

Contact: Sathya Achia Abraham
sbachia@vcu.edu
804-827-0890
Virginia Commonwealth University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... Minn. , Dec. 10, 2014  Data ... physiologic monitoring, has released a new series of ... of preclinical toxicology researchers. M series, part of ... toxicologists collect the best possible physiologic data when ... Adding functional endpoints to toxicology studies has ...
(Date:12/10/2014)... 2014 CIE San Diego has launched an ... connective tissue that enhances care coordination among social service ... client-level information; earned a second $1 million grant from ... seniors aging in community and; will be recognized as ... th 4-6p. CIE San Diego today ...
(Date:12/5/2014)... , Dec. 4, 2014  Tute Genomics, a ... $2.3 million in Series A1 funding led by UK-based ... also participated in the investment round. "We ... healthcare community adopts next-generation sequencing and seeks new approaches ... Reid Robison , MD MBA, and CEO of ...
Breaking Biology News(10 mins):New telemetry implants expected to change how large animal toxicology studies are conducted 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3
... of the Dog in the Twentieth Century, will include an exploration ... dogs that are pure bred, which three years ago resulted in ... concerns about the health of pedigree dogs. "It is a ... modern position as a domestic companion and use in various types ...
... the world,s preeminent gastroenterologists have convened this week ... Annual Scientific Meeting at the Gaylord National Hotel ... to review the latest scientific advances in gastrointestinal ... management. Groundbreaking treatments such as fecal microbiota ...
... An international team of researchers led by investigators in the U.S. ... endocycle, a common cell cycle that fuels growth in plants, animals ... half of the Earth,s biomass. This discovery, led by a geneticist ... Nature , leads to a new understanding of how cells ...
Cached Biology News:It's a dog's life: $800,000 study launched into man's best friend 2New research on GI health unveiled at American College of Gastroenterology's 2011 Meeting 2New research on GI health unveiled at American College of Gastroenterology's 2011 Meeting 3New research on GI health unveiled at American College of Gastroenterology's 2011 Meeting 4New research on GI health unveiled at American College of Gastroenterology's 2011 Meeting 5New research on GI health unveiled at American College of Gastroenterology's 2011 Meeting 6New research on GI health unveiled at American College of Gastroenterology's 2011 Meeting 7New research on GI health unveiled at American College of Gastroenterology's 2011 Meeting 8Research team clarifies mechanics of first new cell cycle to be described in more than 20 years 2Research team clarifies mechanics of first new cell cycle to be described in more than 20 years 3
(Date:12/17/2014)... AUSTIN, Texas , Dec. 16, 2014  Vermillion, ... company focused on gynecologic disease, today announced the next ... into a premier bio-analytics solutions provider with the naming ... to President and Chief Executive Officer, while current Chairman ... will continue to serve as Chairman. These changes are ...
(Date:12/17/2014)... CASI Pharmaceuticals, Inc. (Nasdaq: CASI ... and commercialization of innovative therapeutics addressing cancer and other ... primary commercial focus on China , ... C meeting with the U.S. Food and Drug Administration ... February 2015.  During this meeting the Company will seek ...
(Date:12/17/2014)... 17, 2014   Synageva BioPharma Corp. (NASDAQ: ... products for rare disorders, announced today its presentation at ... San Francisco, CA. ... Officer, will present on Monday, January 12, 2015, at ... be webcast live and may be accessed from the ...
(Date:12/15/2014)... & PETACH TIKVAH, Israel , Dec. ... BCLI ), a leading developer of adult stem ... subsidiary Brainstorm Cell Therapeutics Ltd. was awarded a grant ... Office of the Chief Scientist (OCS).  This is ... of grant support from the Office of the Chief ...
Breaking Biology Technology:Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 3Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 4CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 3CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 4CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 5BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 2BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 3
... MADISON, Wis., Sept. 8 From the transfection experts, Mirus Bio ... , , Mirus has expanded its transfection expertise ... transfection reagent which offers users: , , ... and Lipofectamine(TM) 2000 CD in many cell types. , ...
... , , , CAMBRIDGE, ... VRNM ), a pioneer in the development of next-generation ... previously announced 1-for-12 reverse stock split of the Company,s common ... 9, 2009. Verenium,s shares will continue to trade on ...
... , , $5 ... Western PA Companies , , HARRISBURG, ... will be able to expand and create quality jobs with the ... Rendell said today. , , "The life sciences ...
Cached Biology Technology:Verenium Announces Reverse Stock Split to Take Effect September 9 2Verenium Announces Reverse Stock Split to Take Effect September 9 3Verenium Announces Reverse Stock Split to Take Effect September 9 4PA Helping Life Science Companies Secure Venture Capital Needed to Expand, Gov. Rendell Says 2
... MULTI-FUN Incubator is a compact ... uses a microprocessor controller with a ... temperature and agitation speed. Air circulation ... the incubator. Temperature can be easily ...
...
... of robotic workstations is designed for laboratories ... the ideal automation platform for routine sample ... procedures, improving throughput, process consistency and safety. ... software allows you to control the robotic ...
...
Biology Products: