Navigation Links
Researchers identify new function of protein in cellular respiration
Date:1/28/2009

RICHMOND, Va. (Jan. 28, 2009) Virginia Commonwealth University researchers have found that the protein Stat3 plays a key role in regulating mitochondria, the energy-producing machines of cells. This discovery could one day lead to the development of new treatments for heart disease to boost energy in failing heart muscle or to master the abnormal metabolism of cancer.

In the study, published online Jan. 8 in Science Express, researchers reported that Stat3, a protein previously known to control the activity of genes by acting in the cell nucleus, also plays a key role in cellular energy production.

The team examined oxygen consumption in cultured cells and hearts of mice. They discovered that when Stat 3 protein was missing, cells consumed less oxygen and produced less ATP, the key molecular form of cellular energy. The findings revealed that Stat3 is necessary for the function of the mitochondrial electron transport chain that generates ATP. Changes in energy production and expenditure are essential to maintain cellular homeostasis.

"We found evidence that Stat3 is present in the mitochondria and that it serves to control the production of ATP," said principal investigator Andrew C. Larner, M.D., Ph.D., professor of biochemistry and molecular biology in the VCU School of Medicine, and co-leader of the Immune Mechanisms research program at the VCU Massey Cancer Center.

"We have described a new pathway by which generation of ATP is regulated. This pathway could suggest new ways for Stat3 to be therapeutically manipulated to treat a variety of diseases where there are imbalances between energy generation and energy demands such as occurs in cancer and heart disease," he said.

Next, the team will conduct studies to determine the downstream targets of Stat3 in the mitochondria and identify the physiological role of Stat3 that is localized to the mitochondria in heart disease and cancer.


'/>"/>

Contact: Sathya Achia Abraham
sbachia@vcu.edu
804-827-0890
Virginia Commonwealth University
Source:Eurekalert

Page: 1

Related biology news :

1. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
2. Researchers identify a cell type that limits stroke damage
3. Researchers iron out new role for serotonin
4. Researchers identify 4 genetic hotspots associated with psoriasis
5. Researchers genetically link Lou Gehrigs disease in humans to dog disease
6. Texas Medical Center researchers win collaborative grants
7. Researchers describe protease inhibitor that may aid in diabetic retinopathy treatment
8. Researchers examine developing hearts in chickens to find solutions for human heart abnormalities
9. JDRF-funded researchers discover proteins regulating human beta cell replication
10. Researchers to use K-States BSL-3 Lab for $1 million study of fungus threatening wheat crops
11. Researchers identify potential new weapon in battle against HIV infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... -- Valencell, a leader in performance biometric data sensor ... leaders such as Intel, Jabra, Atlas, and Scosche to ... These products will be showcased at CES 2015, taking ... . "Our partners choose PerformTek biometrics, ... with the clinical data to back it up," said ...
(Date:12/11/2014)... Research and Markets , ... http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition of the ... to their offering. One major ... of multimodal biometric systems. Multimodal biometric systems utilize ... verification and identification purposes. This helps to reduce ...
(Date:12/10/2014)... Dec. 9, 2014  Wake Forest Baptist Medical Center today ... its School of Medicine. Funding for this $50 million ... that will be publicly launched next summer. ... the former 60 series R.J. Reynolds Tobacco Company complex, ... will begin immediately with plans to be ready to ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... fish is good for our brains and memory. But what ... fish, that makes our memory sharper? Medical researchers at ... published their findings in the peer-reviewed journal Applied Physiology, ... his team discovered lab models fed a high-DHA diet had ...
... Steve Moose, an associate professor of maize functional genomics at ... think they may have discovered a new source of heterosis, ... small RNAs (sRNAs), a class of double-stranded RNA molecules that ... refers to the increased vigor or general health, resistance to ...
... the Royal Astronomical Society (RAS) announced a new publishing ... prestigious journals. OUP will assume publication of ... Monthly Notices of the Royal Astronomical Society: Letters , ... Geophysics from January 2013. Professor David Southwood, ...
Cached Biology News:A new source of maize hybrid vigor 2A new source of maize hybrid vigor 3Royal Astronomical Society and Oxford University Press partnership announced 2
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Calif. , Dec. 19, 2014  Roche (SIX: ... of Bina Technologies, Inc. (Bina), a privately held ... , USA. Bina provides a big data ... generation sequencing (NGS) data. Bina,s proprietary on-market Genomic ... and academic researchers to perform fast and scalable ...
(Date:12/19/2014)... -- Decision Resources Group finds that the Latin American ... compound annual growth rate through 2023. This is primarily ... increasing adoption of dental implants. Growing aesthetic consciousness in ... demand for dental biomaterials because they can improve the ... Other key findings from Decision Resources Group,s coverage ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 ... nation’s leading specialty pharmacies, has an expanded team ... clinical pharmacy consultants for prescriber offices in their ... , “We have a variety of Regional ... example, those specializing in hepatitis C help prescribers ...
Breaking Biology Technology:BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 2BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 3
... 7, 2011 DuPont (NYSE: DD ) ... at the JPMorgan Diversified Industries Conference to expect attractive ... selective investment in attractive areas, broad-based growth, especially in ... also reaffirmed DuPont,s 2011 earnings per share (EPS) outlook ...
... June 7, 2011 Infrared Systems International (OTCBB: IFRS) is ... a pilot study of its NatuRx™ HIV/AIDS treatment and will ... AquaLiv concluded a pilot study with two HIV/AIDS ... anniversary of the first reported AIDS victims on June 5th, ...
... its origins in Hamburg. Jrg Weimller, a materials scientist ... Helmholtz Center Geesthacht, has carried out research on this ... Institute for Metal Research in Shenyang, China., The 51-year-old ... which opens the door to a multitude of diverse ...
Cached Biology Technology:DuPont Chair & CEO: Delivering Innovative Solutions and Long-term Growth 2DuPont Chair & CEO: Delivering Innovative Solutions and Long-term Growth 3Infrared Systems International's Subsidiary, AquaLiv, Inc., Strives to Be a Game Changer in Fight Against HIV/AIDS 2Infrared Systems International's Subsidiary, AquaLiv, Inc., Strives to Be a Game Changer in Fight Against HIV/AIDS 3Hard or soft: At the touch of a button 2Hard or soft: At the touch of a button 3
... 5 barrel liners, 5 white cartridge holders, cartridge ... gene gun is a convenient, hand-held device that ... range of targets in vivo. The unit uses ... or RNA-coated gold microcarriers from the inner wall ...
Intestinal Epithelium Differentiation Environment...
... LABTrack provides a familiar interface for ... and warehousing. The transition from paper ... transparent. LABTrack contains an integrated ... and rules mechanism. These functions allow ...
Mouse monoclonal [M2II-12] to MRP2 ( Abpromise for all tested applications). entrezGeneID: 1244 SwissProtID: Q92887...
Biology Products: