Navigation Links
Researchers identify new function of protein in cellular respiration
Date:1/28/2009

RICHMOND, Va. (Jan. 28, 2009) Virginia Commonwealth University researchers have found that the protein Stat3 plays a key role in regulating mitochondria, the energy-producing machines of cells. This discovery could one day lead to the development of new treatments for heart disease to boost energy in failing heart muscle or to master the abnormal metabolism of cancer.

In the study, published online Jan. 8 in Science Express, researchers reported that Stat3, a protein previously known to control the activity of genes by acting in the cell nucleus, also plays a key role in cellular energy production.

The team examined oxygen consumption in cultured cells and hearts of mice. They discovered that when Stat 3 protein was missing, cells consumed less oxygen and produced less ATP, the key molecular form of cellular energy. The findings revealed that Stat3 is necessary for the function of the mitochondrial electron transport chain that generates ATP. Changes in energy production and expenditure are essential to maintain cellular homeostasis.

"We found evidence that Stat3 is present in the mitochondria and that it serves to control the production of ATP," said principal investigator Andrew C. Larner, M.D., Ph.D., professor of biochemistry and molecular biology in the VCU School of Medicine, and co-leader of the Immune Mechanisms research program at the VCU Massey Cancer Center.

"We have described a new pathway by which generation of ATP is regulated. This pathway could suggest new ways for Stat3 to be therapeutically manipulated to treat a variety of diseases where there are imbalances between energy generation and energy demands such as occurs in cancer and heart disease," he said.

Next, the team will conduct studies to determine the downstream targets of Stat3 in the mitochondria and identify the physiological role of Stat3 that is localized to the mitochondria in heart disease and cancer.


'/>"/>

Contact: Sathya Achia Abraham
sbachia@vcu.edu
804-827-0890
Virginia Commonwealth University
Source:Eurekalert

Page: 1

Related biology news :

1. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
2. Researchers identify a cell type that limits stroke damage
3. Researchers iron out new role for serotonin
4. Researchers identify 4 genetic hotspots associated with psoriasis
5. Researchers genetically link Lou Gehrigs disease in humans to dog disease
6. Texas Medical Center researchers win collaborative grants
7. Researchers describe protease inhibitor that may aid in diabetic retinopathy treatment
8. Researchers examine developing hearts in chickens to find solutions for human heart abnormalities
9. JDRF-funded researchers discover proteins regulating human beta cell replication
10. Researchers to use K-States BSL-3 Lab for $1 million study of fungus threatening wheat crops
11. Researchers identify potential new weapon in battle against HIV infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... Prediabetes and Diabetes increasingly consume the healthcare ... immediate attention. , To address the ... impacting low-and middle-income countries, global leaders in ... research in diabetes prevention and development of ... important text. , This book on ...
(Date:7/25/2014)... tractography (DTT), which is derived from diffusion tensor ... motor tracts, such as the corticospinal tract, the ... The corticospinal tract is known to be a ... human brain. Several studies have reported on injury ... addition, some studies have demonstrated recovery of a ...
(Date:7/25/2014)... detected an unknown interaction between microorganisms and salt. When ... droplet of salt water and is left to dry, ... biosaline 3D morphologically complex formations, where they hibernate. Afterwards, ... discovery was made by chance with a home microscope, ... journal and may help to find signs of ...
Breaking Biology News(10 mins):What constitutes an effective response to the global 'diabesity' tsunami? 2Bacteria manipulate salt to build shelters to hibernate 2
... field trials of Miscanthus x giganteus , a towering ... yields, though reduced somewhat after five years of growth, are ... ), another perennial grass used as a bioenergy feedstock. ... yields found in earlier studies of the crop in Europe, ...
... Sciences (AIBS) has selected three individuals as winners of ... This is the third year AIBS has sponsored ... members of the scientific community to showcase for the ... informing natural resources management, addressing climate change, improving human ...
... For some 5,000 years, cultivated silkworms have been spinning ... finest clothing. But current dyeing practices produce wastewater that ... a new, "greener" dyeing method in which they coax ... leaves. Their findings are published in the journal ...
Cached Biology News:The first decade: Team reports on US trials of bioenergy grasses 2The first decade: Team reports on US trials of bioenergy grasses 3AIBS announces winners of Faces of Biology photo competition 2
(Date:7/25/2014)... Muncie, IN (PRWEB) July 25, 2014 ... Administration (FAA) has granted a 60-day extension for the ... of the Special Rule for Model Aircraft established by ... Act of 2012. The 60-day extension establishes the new ... the United States Department of Transportation/FAA notice published in ...
(Date:7/24/2014)... July 24, 2014 Gain recognition ... Supply Chain of the biotech industry. Nominations are ... Awards, brought to you by the Bio ... of supply chain management professionals for the past ... stakeholders of the Biotech industry – Manufacturers, Service ...
(Date:7/24/2014)... forces worldwide rely on sophisticated equipment, trained personnel, ... public areas against terrorist attacks. A revolutionary new ... to make their job much easier. , The ... of Tel Aviv University ,s School of Chemistry ... by the Herzliya company Tracense, picks up the ...
(Date:7/24/2014)... natural and synthetic processes prefer to settle into ... energyit is within the realm of non-equilibrium conditions ... changes in energy and phases, such as temperature ... allow humans to regulate their body temperature, airplanes ... seismic activity. , But even though these ...
Breaking Biology Technology:FAA Grants Comment Extension at the Request of AMA 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3Nano-sized chip 'sniffs out' explosives far better than trained dogs 2New approach to form non-equilibrium structures 2
... Companies looking to thrive in an increasingly competitive atmosphere are ... on one rather unusual method: speed-networking, a concept based on ... to this story now using RealPlayer , ,Its not ... eat the slow. That phrase was used to kick off ...
... still beaming on Saturday, a day after the Legislatures upper ... and build a stronger in-state network for entrepreneurs , ,Not ... fall, but this is the most important so far to ... with Democrats and Republicans alike in helping to pass the ...
... - EraGen Biosciences , a Wisconsin-based life ... and technologies that accelerate the drug discovery process, ... that it has selected ITOCHU Corporation ... integrated phylogenomics product, Master Catalog , in ...
Cached Biology Technology:Looking to be Competitive? Try Speed Networking 2Senate Passes an Investment Capital Package; the Assembly Should Follow Suit 2Senate Passes an Investment Capital Package; the Assembly Should Follow Suit 3EraGen Expands in Japan 2
Lingo-1 (K-13)...
... well-characterized tissue-specific stem cells that exhibit remarkable ... life-long maintenance of the hematopoietic system. HSC ... bone marrow where hematopoiesis is continuously taking ... cord blood, fetal liver, adult spleen and ...
Human DEP-1/CD148 Fluorescein MAb (Clone 143-41) Protein Family: Granulocyte Markers, Monocyte Markers, Phosphatases & Regulators, Other Dendritic Cell Molecules...
MOUSE ANTI PORCINE SLA 1:FITC Immunogen: Porcine peripheral blood mononuclear cells....
Biology Products: