Navigation Links
Researchers identify new drug target that stimulates
Date:9/6/2011

se mice were able to clear glucose from the blood more efficiently than control mice with Bace2.

Dr. Stoffel and his team next aimed to inhibit Bace2 in an effort to control and promote the growth of beta cells. To do so, they teamed up with scientists at Hoffmann-LaRoche who developed a chemical compound that could inhibit Bace2. When the scientists gave this compound to mice, they saw that it inhibited Bace2 and stimulated the growth of new beta cells. Importantly, Bace2, and not its close relative Bace1, which is implicated in other diseases, cleaves the Tmem27 protein, suggesting the potential for developing a Bace2 inhibitor as a diabetes-specific therapy.

In addition to identifying a new drug target for promoting beta cell regeneration, Dr. Stoffel's work may also help in developing tests to measure the amount of Tmem27 fragments in the blood a biomarker that could be used as an index of beta cell number.

"This is an exciting and potentially impactful finding," says Patricia Kilian, Ph.D., scientific program director of regeneration research at JDRF. "It's an example of how researchers make an early observation and follow up on it, and then take it to the next level where it has translational potential the potential to be developed into a drug that promotes the growth of beta cells for diabetes."


'/>"/>

Contact: Joana Casas
mcasas@jdrf.org
212-479-7560
Juvenile Diabetes Research Foundation International
Source:Eurekalert

Page: 1 2

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... Biologically Inspired Engineering at Harvard University today announced ... by a newly formed private company to accelerate ... products. The announcement follows a worldwide ... (OTD) and the start-up Emulate Inc., relating to ... platform. , "This is a big win ...
(Date:7/27/2014)... largest prevalence studies to date, researchers from the U.K. ... the hepatitis C virus (HCV). Findings published in Hepatology, ... of Liver Diseases, indicate that genotype 1 is the ... of which one-third reside in East Asia. Genotype 3, ... most prevalent, followed by genotypes 2, 4, 6, and ...
(Date:7/27/2014)... single computer cannot always find the solution a user ... cluster of computers that analyze a massive data set ... history to present you with targeted ads, and how ... movie. But big data is about more than just ... are generating unprecedented quantities of information. That data may ...
Breaking Biology News(10 mins):Wyss Institute's technology translation engine launches 'Organs-on-Chips' company 2Wyss Institute's technology translation engine launches 'Organs-on-Chips' company 3Hepatitis C virus genotype 1 is most prevalent worldwide 2New tools help neuroscientists analyze 'big data' 2New tools help neuroscientists analyze 'big data' 3New tools help neuroscientists analyze 'big data' 4New tools help neuroscientists analyze 'big data' 5
... San Diego have identified a potential red tide killer. ... accumulate rapidly in dense concentrations have been on the ... dollars in worldwide losses to fisheries and beach tourism ... referred to as harmful algal blooms, remain unpredictable in ...
... Using classroom, hands-on activities can help instructors to ... Despite its importance, the diversity in soil microbes ... natural resource classrooms composed primarily of undergraduates who ... the candy comes into play. , Stephanie ...
... at City of Hope and the California Department of ... detect botulinum neurotoxin. The toxin is one of the ... and is considered a major potential bioterrorism threat agent. ... the online journal PLoS ONE ( http://www.plosone.org/doi/pone.0002041 ). ...
Cached Biology News:Scripps Oceanography Research pegs ID of red tide killer 2Scripps Oceanography Research pegs ID of red tide killer 3The sweet world of soil microbiology 2Researchers develop new ultrasensitive assay to detect most poisonous substance known 2
(Date:7/28/2014)... 28, 2014  David Hardison, Ph.D., vice president ... , has been elected chairman of the board ... non-profit working to establish common protocols around the ... relates to electronic health records. ... collaborating with organizations across the research and health ...
(Date:7/28/2014)... (PRWEB) July 28, 2014 Appistry, ... services that bring the power of genomics to next-generation ... Appistry Pipeline Challenge . , Two Appistry ... of the National Center for Genome Resources, and Mr. ... and Clinics of Kansas City. Rounding out the panel ...
(Date:7/28/2014)... -- InterMune, Inc. (NASDAQ: ITMN ) today announced ... results at the close of the U.S. markets on ... will be hosted by InterMune at 4:30 p.m. Eastern ... others may participate in the conference call by dialing ... of the webcast and teleconference will be available on ...
(Date:7/28/2014)... The National Model Aviation Museum, located ... pleased to announce that it has been granted full ... United States Air Force. , The certification is the ... this spring with an on-site inspection by Sarah Sessions, ... The National Museum of the United States Air ...
Breaking Biology Technology:ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 2ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 3Appistry Names Industry Experts from the National Center for Genome Resources and Mercy Children's, Kansas City, to Judge Pipeline Challenge Competition 2InterMune to Release Second Quarter Financial Results on August 6 2AMA’s National Model Aviation Museum Granted Full Civilian Museum Certification by the National Museum of the United States Air Force 2
... FRANCISCO, March 7, 2012  More than 1,100 leaders from ... Francisco for the two-day conference CALBIO2012: Driven by Patients ... patient access to new treatments through partnering and collaborative ... BIOCOM are organizing a statewide meeting for California,s life ...
... Palatin Technologies, Inc. (NYSE Amex: PTN ) ... ROTH OC Growth Stock Conference on Tuesday, March 13, 2012, ... at the Ritz Carlton Laguna Niguel in Dana Point, CA. ... Officer of Palatin Technologies, will provide an update on Palatin,s ...
...  Synthetic Biologics, Inc.  (NYSE Amex: SYN ), ... medicines for serious illnesses, announced today that Jeff Riley, ... ROTH Capital Partners 24th Annual Growth Stock Conference. The ... Ritz Carlton in Dana Point, CA. Mr. Riley will ...
Cached Biology Technology:First Statewide Biotech Meeting Focuses on Patient Access, Innovation 2Synthetic Biologics to Present at ROTH Annual Growth Stock Conference 2
... MULTI-FUN Incubator is a compact ... uses a microprocessor controller with a ... temperature and agitation speed. Air circulation ... the incubator. Temperature can be easily ...
... of 3 siRNAs specifically targeted to your ... product. The siTrio reagent guarantees you get ... gene when used under standard conditions (100 ... optimal transfection with one of B-Bridges controls). ...
... 96 x 0.2 ml reaction module is ... It is equipped with an interchangeable 96-well ... compatible with optical modules for real-time PCR ... algorithm, block, or in-sample probe. It includes ...
... MULTI-FUN Incubator is a compact ... uses a microprocessor controller with a ... temperature and agitation speed. Air circulation ... the incubator. Temperature can be easily ...
Biology Products: