Navigation Links
Researchers identify new anti-tumor gene
Date:12/16/2008

RICHMOND, Va. (Dec. 16, 2008) Researchers from Virginia Commonwealth University have identified a new anti-tumor gene called SARI that can interact with and suppress a key protein that is overexpressed in 90 percent of human cancers. The discovery could one day lead to an effective gene therapy for cancer.

According to Paul B. Fisher, M.Ph., Ph.D., professor and chair of the Department of Human and Molecular Genetics and director of the VCU Institute of Molecular Medicine in the VCU School of Medicine, and lead investigator of the study, this novel gene highlights a previously unrecognized molecular pathway underlying the anti-tumor action of interferon, INF.

In the study, published online in the Dec. 8 issue of the Proceedings of the National Academy of Sciences, researchers report the discovery of a new gene named SARI, which was uncovered by a powerful technique pioneered in the Fisher laboratory known as subtraction hybridization. SARI, which is induced by a potent immune system modulator called interferon, was found to suppress growth and survival of tumor cells by interfering with the action of cancer cell molecules that drive cell division and promote survival.

The investigators delivered SARI to cancer cells using a virus and the infected cancer cells subsequently stopped dividing and died. Since 90 percent of all cancer types rely on a similar mechanism to proliferate and evade destruction, Fisher noted that SARI could be an effective anti-cancer treatment for many tumors.

"Additionally, IFNs are powerful immune modulating agents that contribute to the immune response to cancer and they are effective inhibitors of new blood vessel formation, the process of angiogenesis, which is obligatory for the growth of both primary and metastatic cancers," said Fisher, who is the first incumbent of the Thelma Newmeyer Corman Endowed Chair in Cancer Research with the VCU Massey Cancer Center.

Currently, IFNs are relevant in the clinical treatment of a number of solid tumors and hematological malignancies, such as melanoma, renal cell carcinoma, malignant glioma, lymphomas and leukemias, either as a monotherapy or as an adjuvant to chemotherapy of radiotherapy.

"We have uncovered a new way by which interferon can induce anti-tumor activity. The identification of SARI also provides a new potential reagent for the selective killing of tumor cells," said Fisher.

"The present study indicates that interferon can suppress cancer growth by inhibiting expression of a cancer-dependent transcription factor that controls genes that regulate cancer cell growth. The SARI gene may provide novel and selective gene therapy applications for cancer. It could also prove amenable for inhibiting proliferative disorders that depend on AP-1 activity," he said. AP-1 plays a key role in regulating proliferation and transformation of cancer cells.

The team is now developing improved approaches to more effectively target the delivery of SARI. Fisher said these studies will be crucial for exploiting the cancer-selective killing activity of this gene and enhancing its therapeutic applications.


'/>"/>

Contact: Sathya Achia Abraham
sbachia@vcu.edu
804-827-0890
Virginia Commonwealth University
Source:Eurekalert

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... UBM,s Advanced Design and Manufacturing event in ... and evolving technology through its 3D Printing and Smart ... the expo portion of the event and feature a ... on trending topics within 3D printing and smart manufacturing. ... will take place June 13-15, 2017 at the Jacob K. ...
(Date:4/11/2017)... 2017 NXT-ID, Inc. (NASDAQ:   NXTD ... the appointment of independent Directors Mr. Robin D. Richards ... of Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief ... to their guidance and benefiting from their considerable expertise as ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC ... announced that the United States Patent and Trademark Office ... broadly covers the linking of an iris image with ... transaction) and represents the company,s 45 th issued ... patent is very timely given the multi-modal biometric capabilities ...
Breaking Biology News(10 mins):
(Date:9/18/2017)... , Sept. 18, 2017   Montrium , a growing leader ... exciting new partnership with a groundbreaking non-profit research organization, Multidisciplinary ... ... psychotherapy studies for PTSD ... recently granted Breakthrough Therapy Designation to MDMA for the treatment of ...
(Date:9/14/2017)... ... September 14, 2017 , ... ... pharma and biotech at the third annual DrugDev Summit, November 7-8, 2017 in ... the world’s most progressive clinical research leaders for best practice case studies, keynote ...
(Date:9/14/2017)... (PRWEB) , ... September 14, 2017 , ... AIM Global, ... Medical Tracking Systems Inc. has won the 2017 Case Study Competition for AIDC. ... which provide benefits that decrease risk” and push the adoption of automated data collection ...
(Date:9/12/2017)... Brunswick, NJ (PRWEB) , ... September 12, 2017 ... ... one of the fastest growing b2b product testing and development companies will be ... expanded service offerings. , Contract Pharma is an educational ...
Breaking Biology Technology: