Navigation Links
Researchers identify need to sample multiple tumor zones in breast cancer
Date:6/14/2012

Philadelphia, PA, June 15, 2012 Certain short strands of RNA, known as microRNAs (miRNAs), have been linked to the progression and metastasis of breast cancer and may provide information about prognosis. However, studies of miRNA expression profiles often report conflicting findings. While the potential for using miRNAs in breast cancer diagnosis is promising, scientists report in a new study published online today in The Journal of Molecular Diagnostics that differences in the amount and types of miRNA within breast tumors can be misleading.

"Personalized medicine will be the future of cancer care," explains lead investigator Stefanie Avril, MD, of the Technical University of Munich. "However, taking a single tumor biopsy for defining individual treatment is probably oversimplified, and we need to take into account the heterogeneity of tumors. "We found considerable differences in the expression of miRNAs associated with breast cancer within a single tumor (referred to as intratumoral heterogeneity). The use of miRNA for diagnosis or prognosis requires sampling at several different tumor locations and of several tumor-involved lymph nodes."

Researchers collected 132 tumor samples from 16 patients who underwent either lumpectomy or mastectomy for large primary invasive breast cancer. Samples were taken from defined tumor zones: the center of the tumor, the periphery, and the area between. Samples were also taken from lymph nodes, if metastases were present. The expression of four miRNAs (miR-31, miR-335, miR-10b, and miR-210) and four control genes (let-7a, miR-16, RNU48, and RNU44) was assessed.

The researchers found significant variation in miRNA expression, from samples both within primary breast cancers and within lymph node metastases from the same patient. The extent of heterogeneity was very similar within the defined tumor zones and between different zones.

To illustrate why intratumoral heterog
'/>"/>

Contact: David Sampson
jmdmedia@elsevier.com
215-239-3171
Elsevier Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. London researchers discover novel mechanism involved in key immune response
2. NTU researchers study little mighty creature for scientific breakthrough
3. UTMB researchers create powerful new method to analyze genetic data
4. Researchers at GW receive federal funds to study the effect earthquakes have on nuclear reactors
5. Stanford researchers help predict the oceans of the future with a mini-lab
6. Researchers complete the first epigenome in Europe
7. UC Santa Barbara researchers develop synthetic platelets
8. Researchers say tart cherries have the highest anti-inflammatory content of any food
9. CSHL researchers solve structure of human protein critical for silencing genes
10. Researchers identify genetic markers to predict male fertility
11. University of Hawaii Cancer Center researchers create new anti-cancer drug
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2015)... June 24, 2015 Biometry authentication provider ... biometric password solution one face in. ... one face in, entering the expanding biometric ... affordable multifactor-authentication biometric answer to the password problem. ... in partnership with KeyLemon, one face in allows ...
(Date:6/23/2015)... 22, 2015 Research ... of the "Body-Worn Temperature Sensors Market - ... Forecast 2014 - 2020" report to their ... of the global body-worn temperature sensors market. The ... on the basis of types, care setting, patient ...
(Date:6/23/2015)... , June 23, 2015  Crossmatch™, ... and authentication solutions, today announced enhanced functionality of ... authentication solution.  The enhancements build on the ... the DigitalPersona Altus platform and provide expanded ... In today,s environment of increasing ...
Breaking Biology News(10 mins):KeyLemon Announces Partnership With Biometric Password Solution onefacein 2Body-Worn Temperature Sensors Market - Global Industry Analysis 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2
... vaginal infection linked to preterm birth appears to escalate ... University of Pittsburgh School of Medicine study presented today ... Society for Obstetrics and Gynecology in Boston. When ... preterm birth goes up, said Hyagriv Simhan, M.D., M.S.C.R., ...
... hair cells dominates the process of sound amplification in ... those cells dominates the response in non-mammals , A ... inner ear amplify sound in mammals appears to have ... rather than vibrating, hair-like cilia, according to investigators at ...
... on Emerging Nanotechnologies Director David Rejeski, “Today, FDA took ... oversight. If nanotechnology regulation was a baseball game, FDA ... But the agency must act rapidly to adopt and ... quickly and building on the recommendations in the Task ...
Cached Biology News:Risk of common vaginal infection linked to preterm birth appears higher for blacks 2St. Jude study solves mystery of mammalian ears 2St. Jude study solves mystery of mammalian ears 3FDA sees nanotech challenges in every product category it regulates 2
(Date:6/30/2015)... , June 30, 2015  Today, Americord Registry, one ... announced Andrew Horne , a partner at Kirkland & ... Logo - http://photos.prnewswire.com/prnh/20150630/226958LOGO   ... Americord,s Advisory Board," says Martin Smithmyer , CEO of ... his legal career that will assist Americord,s growth and vision." ...
(Date:6/30/2015)... VA (PRWEB) , ... June 30, 2015 , ... ... strategy services to the federal government, announced in a paper published this week ... uncovered a potential problem with the diagnostic techniques currently used to detect the ...
(Date:6/30/2015)... , June 30, 2015  The University ... in Biosciences (CCE/Bio) and UC San Diego Extension ... to be held Aug.  12 – 14, 2015, ... This three-day workshop provides an intense exposure to ... biotechnology, and is well-suited to biologists, process engineers ...
(Date:6/30/2015)... June 30, 2015  The Dr. Samadi Prostate Cancer Center ... offering a full suite of new genetic testing methods for ... for diagnosing prostate cancer. Dr. Samadi,s ... tests for assessing the risk and optimizing the diagnosis of ... very excited to now offer these revolutionary genetic tests to ...
Breaking Biology Technology:Americord Registry Announces Andrew Horne as Advisory Board Member 2Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 2Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 3Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 4UC San Diego Extension to Offer Third Annual Microbial Fermentation Workshop 2New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 2New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 3New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 4New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 5
... Mass. and TORONTO, Dec. 1, 2011 Generex Biotechnology ... update on the status of the clinical and ... buccal insulin spray product. Work has ... new analyses), and revising all of the extant ...
... of two leading cell image resource centers now provides ... and analyzing microscope images in great detail. The American ... for Microscopy and Imaging Research (NCMIR) at the University ... provide a unified interface. This union extends ASCB,s The ...
... displays in the mid-1960s, display electronics have undergone ... have shown several advantages over LCDs, including their ... high power efficiency and quick response. ... phones, digital cameras and other portable devices. But ...
Cached Biology Technology:Generex Provides Update on Generex Oral-lyn™ Clinical & Regulatory Program 2Generex Provides Update on Generex Oral-lyn™ Clinical & Regulatory Program 3Generex Provides Update on Generex Oral-lyn™ Clinical & Regulatory Program 4Two Top Biological Imaging Centers Offer Powerful Free Online Tool to Researchers, Educators, and Public 2Two Top Biological Imaging Centers Offer Powerful Free Online Tool to Researchers, Educators, and Public 3UCLA researchers demonstrate fully printed carbon nanotube transistor circuits for displays 2
... (MOPS Buffered) has been developed specifically for ... solution. HRP Stabilizer prevents the loss ... of the antibody or protein antigen portion ... at 0.2 microns., ,Contents: Aqueous, protein-containing ...
384 Well PCR Plate Carrier for Thermo-Sealer...
... Frame products feature a dual strength adhesive system ... after use. The adhesives on either side of ... which adheres to the glass has an easy ... the coverslip, forms a stronger bond. This means ...
These 18x18 square No.1 Corning cover glasses are made from No. 0211 zinc titania glass and are 0.16 to 0.19mm thick....
Biology Products: